Eicosanoids in Immune Regulation

  • T. J. Rogers
Part of the Advances in Eicosanoid Research book series (AEIR, volume 3)


The analysis of the role of the products of the lipoxygenase (LO) pathway of arachidonic acid metabolisn in the immune system has consumed a great deal of attention recently. It is clear that the biochemical events involved in the metabolism of arachidonic acid are still not fully defined, and it is reasonable to assume that our appreciation of the role of LO products in various biological responses is far from complete. Until the present time, studies have been conducted either with purified LO products or with certain ‘specific’ inhibitors of LO activity. Our ability to identify, and purify, additional LO products and inhibitors will certainly assist in the understanding of the role of this pathway in the immune response. Our understanding of the precise immune cell target of the effect of these LO products is still evolving, as is our information concerning the biochemical events which mediate their effects. Finally, we are still in the process of dissecting the cellular and molecular nature of immune responses; thus, information derived from experiments conducted with LO products and inhibitors must be evaluated with the understanding that the mechanism of any effect may be uncertain until a later time.


Arachidonic Acid Accessory Cell Arachidonic Acid Metabolism Arachidonic Acid Metabolite Primary Antibody Response 
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