Eicosanoids and gastrointestinal motility

  • P. K. Moore
Part of the Advances in Eicosanoid Research book series (AEIR, volume 2)


The effect on gastrointestinal motility of prostaglandins, thromboxanes and more recently the leukotriene family has been enthusiastically researched ever since Kurzrok and Lieb1 first demonstrated the contractile effect of seminal ‘prostaglandin’ on the isolated rabbit gut preparation. In the space of the last fifty years the gastrointestinal tract has been shown to be an excellent source of the enzymes responsible for the synthesis and break-down of eicosanoids and this, coupled with their potent biological effects on gut motility and secretions, has prompted a search for their physiological role(s) in this part of the body.


Longitudinal Muscle Circular Muscle Gastrointestinal Motility Circular Muscle Layer Lower Oesophageal Sphincter 
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