Protection against mucosal damage: Mechanism of action of eicosanoids

  • A. Robert
Part of the Advances in Eicosanoid Research book series (AEIR, volume 2)


In addition to inhibiting gastric acid secretion, several prostaglandins exert a protective effect on the gastrointestinal mucosa. This is a property by which prostaglandins, given at non-antisecretory doses, prevent gastric and intestinal mucosal necrosis produced by a variety of noxious agents. This property was first demonstrated in experimental animals and has been reproduced in humans. Gastric cytoprotection can be divided into three types: direct, adaptive and functional. We shall review the experimental evidence for each type of cytoprotection, present data on duodenal cytoprotection, and discuss hypotheses to explain the phenomenon.


Duodenal Ulcer Gastric Secretion Mucosal Blood Flow Unstirred Layer Gastric Mucosal Blood Flow 
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© MTP Press Limited 1988

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  • A. Robert

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