The Physico-chemical Defect

  • R. T. Holzbach
  • R. L. Barnhart
  • J. M. Nader


About 20 years ago, an era of major advances in clinical and basic research into gallstone pathogenesis began when the principles of physical chemistry were applied to cholesterol solubilisation and transport. The major (experimental) outcome was the reasonably accurate clinical definition of cholesterol saturation and supersaturation. Supersaturation, the indispensable prerequisite to cholesterol crystallisation and precipitation, was the first key discovery of this era of advances.


Bile Acid Cholesterol Gallstone Hepatic Bile Gallbladder Bile Biliary Cholesterol 
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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • R. T. Holzbach
    • 1
  • R. L. Barnhart
    • 1
  • J. M. Nader
    • 1
  1. 1.Department of Gastroenterology and Research Institute, Cleveland Clinic FoundationClevelandUSA

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