Gastric microvasculature and mucosal protection

  • P. E. O’brien


The hypothesis that ischaemia is a central factor in the pathogenesis of gastric mucosal disease was first proposed by Virchow in 1853. That hypothesis remains unproven today although data have been collected characterizing gastric microcirculation, identifying effects of damaging and protective or therapeutic agents on the microvasculature, and demonstrating associations between alteration of gastric microcirculation and various forms of gastric erosion and ulceration. This review selectively describes the structure and function of the microvasculature as it relates to known methods of gastric mucosal defence, reviews the studies of an association between changes in the microcirculation and changes in the capacity of the mucosa to resist injury and examines links between the microcirculation and acid peptic disease of the stomach.


Gastric Mucosa Acid Secretion Stress Ulcer Gastric Mucosal Injury Haemorrhagic Shock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  • P. E. O’brien

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