Antigenic Phenotype and Experimental Herpes Simplex Virus Infection of Cultured Human Fetal Neural Cells

  • P. G. E. Kennedy


Human neural cell cultures have proved to be a useful tool in studying the developmental biology of the human nervous system1, 2. These tissue culture systems have also been used in a variety of ways to investigate the pathogenesis of various neurological diseases in which immunopathological mechanisms may be important3–5 and the susceptibility of human neural cells to infection with viruses6, 7. We have favoured the use of cultured human fetal neural cells in such studies because of their greater relevance to human disease compared with cell cultures derived from animal tissues, and also in view of the obvious ethical contraindications to studying such cells in vivo.


Schwann Cell Herpes Simplex Virus Type Herpes Simplex Virus Encephalitis Tetanus Toxin Antigenic Phenotype 
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© Kluwer Academic Publishers 1988

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  • P. G. E. Kennedy

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