Dysmyelination in Transgenic Mice Containing the Early Region of JC Virus
JC virus is a human papovavirus that has been implicated as the causative agent in the chronic human demyelinating disease progressive multifocal leukoencephalopathy (PML). Although the virus is widespread in human populations1, 2, PML in a rare opportunistic disease that occurs primarily in patients with compromised immune systems3. The incidence of PML has increased recently in association with HIV infection4. Numerous studies have shown viral particles within abnormal oligodendrocytes from PML brains5 and the aetiology of demyelination is thought to be due to lytic destruction of these myelin-forming cells. Astrocytes can have bizarre morphologies in PML brains that include some features of transformed cells. Virions are rarely found in electron micrographs of these morphologically altered cells5.
KeywordsTransgenic Mouse Myelin Basic Protein Progressive Multi Focal Leukoencephalopathy Myelin Sheath Early Region
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