Structure and function of the hepatic sinusoidal wall

  • L. Bouwens
  • A. Geerts
  • E. Wisse


The hepatic blood capillaries, called sinusoids because they have a tortuous course, are lined by a wall of cells which, at the same time, form a barrier and a pathway for exchange between the blood and the hepatic parenchyma. This wall is composed of three different cell types: the endothelial cell, the Kupffer cell and the pit cell. Behind the sinusoidal lining, a fourth sinusoidal cell type occurs, the fat-storing or Ito cell, which will be discussed in another chapter. It has become clear that these cells serve a number of different functions important during both homoeostasis and pathological conditions1.


Kupffer Cell Transmission Electron Micrograph Sinusoidal Endothelial Cell Sinusoidal Endothelium Hepatic Macrophage 
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© Springer Science+Business Media Dordrecht 1988

Authors and Affiliations

  • L. Bouwens
  • A. Geerts
  • E. Wisse

There are no affiliations available

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