Abstract
Teleosts provide sensitive animal models for use in carcinogenesis studies1–4. The Mt. Shasta strain of rainbow trout (Salmo gairdneri) is the most sensitive animal model used to study the tumorigenic effects of aflatoxin4. The brown bullhead (Ictalurus nebulosus) has emerged as a freshwater teleost species which is sensitive to induction of tumours by chemical carcinogen exposure, both experimentally in the laboratory and in the environment5–10. The brown bullhead, as well as other teleost species, may serve as sentinel organisms for the detection of biohaz-ardous material in the environment2–6. We report for the first time the light-and electron-microscopic features of experimentally induced hepatic tumours 9 months after 28-day exposure to an aqueous solution (100 ppm) of diethylnitrosamine (DENA) in 1 y old male and female brown bullheads. Lesions in the bullhead liver will be described in terms derived from the study of mammalian (rodent) hepatocarcinogenesis. Microscopic features of experimentally induced hepatic tumours will be compared with hepatic tumours found in feral brown bullheads previously sampled from the Black River, Lorain, Ohio. However, before descriptions and interpretations of the pattern and progression of lesions seen in bullhead liver during carcinogenesis can be made, knowledge of the normal architecture and component cell types is necessary.
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Hampton, J.A., Klaunig, J.E., Goldblatt, P.J. (1988). Ultrastructure of hepatic tumours in teleosts. In: Motta, P.M. (eds) Biopathology of the Liver. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1239-7_12
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DOI: https://doi.org/10.1007/978-94-009-1239-7_12
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