ATP plays a central role in energy metabolism as a carrier of chemical energy from catabolic reactions to anabolic reactions. It has two high-energy phosphate bonds which give a free energy of 14–16 kcal/mol on hydrolysis. Since ATP was first isolated in 1929 from a tissue (muscle) having high glycolysis activity, by Lohmann, and Fiske and Subbarow, the mechanism of its formation has been studied through elucidation of the mechanisms of the glycolytic pathway and the respiratory chain. Thus, ATP is an important chemical in biochemical research and medicine. Recently, ATP has also attracted much attention as the energy donor in bioreactors for the production of useful metabolites.


Yeast Cell Phytic Acid Adenylate Kinase Methylotrophic Yeast Crude Enzyme Preparation 
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Copyright information

© Elsevier Science Publishers Ltd 1989

Authors and Affiliations

  • Y. Tani
    • 1
  1. 1.Research Center for Cell and Tissue CultureKyoto UniversityKyotoJapan

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