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Infection in the Patient with Cancer

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Part of the book series: Cancer Growth and Progression ((CAGP,volume 7))

Abstract

Infection and hemorrhage are the major limiting, life threatening toxicities occurring during the “standard” therapy for patients with leukemia and the intensive treatment of patients with solid tumors. This chapter will therefore review the current approach to the diagnosis, treatment and prevention of infection.

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References

  1. Bisno AL: Hyposplenism and overwhelming pneumococcal infection: A reappraisal. Am J Med Sci 262: 101, 1971

    Article  PubMed  CAS  Google Scholar 

  2. Bodey GP: Infections in cancer patients. Cancer Treat Rev 2: 89, 1975

    Article  PubMed  CAS  Google Scholar 

  3. Bodey GP, Buckley M, Sathe YS, Freireich EJ: Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med 64: 328, 1966

    PubMed  CAS  Google Scholar 

  4. de Jongh CA, Joshi JH, Newman KA et al: Antibiotic synergism and response in gram-negative bacteremia in granulocytopenic cancer patients. Am J Med 80: 96, 1986

    Article  PubMed  Google Scholar 

  5. Fahey JL, Scoggins R, Utz JP, Szwed CF: Infection, antibody response and gamma globulin components in multiple myeloma and macroglobulinemia. Am J Med 35: 698, 1963

    Article  PubMed  CAS  Google Scholar 

  6. Gurwith MJ, Brunton JL, Lank BA et al.: A prospective controlled investigation of prophylactic trimethoprim/sulfamethoxazole in hospitalized granulocytopenic patients. Am J Med 66: 248, 1979

    Article  PubMed  CAS  Google Scholar 

  7. Johanson WG, Pierce AK, Sanford JP: Changing pharyngeal flora of hospitalized patients. Emergence of gram-negative bacilli. N Engl J Med 281: 1137, 1969

    Article  PubMed  CAS  Google Scholar 

  8. Serum bactericidal assay: Technical aspects and clinical correlations. Klastersky J, Schimpff S (Guest Editors) Europ J Clin Microbial 5: 57, 1986

    Google Scholar 

  9. Klastersky J, Cappel R, Daneau D: Clinical significance of in vitro synergism between antibiotics in gram-negative infections. Antimicrob Ag Chemother 2: 470, 1972

    CAS  Google Scholar 

  10. Lau WK, Young LS, Black RE et al.: Comparative efficacy and toxicity of amikacin/carbenicillin versus gentamicin/carbenicillin in leukopenic patients. A randomized prospective trial. Am J Med 62: 959, 1977

    Article  PubMed  CAS  Google Scholar 

  11. Pizzo PA: After empiric therapy: What to do until the granulocyte comes back. Rev Infect Dis 9: 214, 1987

    Article  PubMed  CAS  Google Scholar 

  12. Pizzo PA, Schimpff SC: Strategies for the prevention of infection in the myelosuppressed or immunosuppressed cancer patient. Cancer Treat Rep 67: 223, 1983

    PubMed  CAS  Google Scholar 

  13. Remington JS: The compromised host. Hosp Prac 7: 59, 1972

    Google Scholar 

  14. Remington JS, Schimpff SC: Please don’t eat the salads. N Engl J Med 304: 433, 1981

    Article  PubMed  CAS  Google Scholar 

  15. Schimpff SC: Diagnosis of infection in patients with cancer. Europ J Cancer 11: 29, 1975

    Google Scholar 

  16. Schimpff SC: Therapy of infection in patients with granulocytopenia. Med Clin No Amer 61: 1101, 1977

    CAS  Google Scholar 

  17. Schimpff SC: Infection prevention in patients with cancer and granulocytopenia. In: Infections Complicating the Abnormal Host, edited by Grieco MH, Yorke Medical Books, New York, pp 926–950, 1980

    Google Scholar 

  18. Schimpff SC: Infections in the compromised host. In: Principles and Practices of Infectious Diseases, edited by Mandell GL, Douglas RG Jr, Bennett JE (3rd edition), Wiley, New York, 1989

    Google Scholar 

  19. Schimpff SC: Empiric antibiotic therapy for granulocytopenic cancer patients. Am J Med 80: 13, 1986

    PubMed  CAS  Google Scholar 

  20. Schimpff SC, Young VM, Greene WH et al.: Origin of infection in acute nonlymphocytic leukemia: Significance of hospital acquisition of potential pathogens. Ann Intern Med 77: 707, 1972

    PubMed  CAS  Google Scholar 

  21. Sickles EA, Greene WH, Wiernik PH: Clinical presentation of infection in granulocytopenic patients. Arch Intern Med 135: 715, 1975

    Article  PubMed  CAS  Google Scholar 

  22. Sleijfer DT, Mulder NH, deVries-Hospers HG et al.: Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. Europ J Cancer 16: 859, 1980

    Article  CAS  Google Scholar 

  23. Steere AC, Mallison GF: Handwashing practices for the prevention of nosocomial infections. Ann Intern Med 83: 683, 1975

    PubMed  CAS  Google Scholar 

  24. Wade JC, Schimpff SC: Infections in patients with suppressed cellular immunity. In: Medical Complications in Cancer Patients, edited by Klastersky J, Staquet MJ, Raven Press, New York, pp 273–290, 1981

    Google Scholar 

  25. Wade JC, Schimpff SC: Epidemiology and prevention of infection in the compromised host. In: Clinical Approach to Infection in the Compromised Host, 2nd Edition, edited by Rubin RH, Young LS, Plenum Press, New York, pp. 5–40, 1988

    Google Scholar 

  26. Wade JC, Schimpff SC, Hargadon MT et al.: A comparison of trimethoprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukemia. N Engl J Med 304: 1057, 1981

    Article  PubMed  CAS  Google Scholar 

  27. Winston DJ, Schiffman G, Wang DC et al.: Pneumococcal infections after human bone-marrow transplantation. Ann Intern Med 91: 835, 1979

    PubMed  CAS  Google Scholar 

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© 1989 Kluwer Academic Publishers

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Schimpff, S.C. (1989). Infection in the Patient with Cancer. In: Brunson, K.W. (eds) Local Invasion and Spread of Cancer. Cancer Growth and Progression, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1093-5_19

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  • DOI: https://doi.org/10.1007/978-94-009-1093-5_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6982-3

  • Online ISBN: 978-94-009-1093-5

  • eBook Packages: Springer Book Archive

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