Abstract
Figures 1–3 show the differentiation pathways, markers, and associated malignancies for hematopoietic cells, B lymphocytes, and T lymphocytes, respectively. As can be seen from the figures, distinct malignancies have been shown to have surface antigen characteristics similar to cells at virtually every identified differentiation step.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
A. Differentiation and migration patterns of hematopoietic cells
Hanks GE: In vitromigration of colony forming units from shielded bone marrow in the irradiated mouse. Nature203: 1393, 1964
Hanks GE, Ainsworth EJ: Endotoxin protection and colony-forming units. Radia Res32: 367, 1964
Maloney MA, Patt HM: Migration of cells from shielded to irradiated marrow. Blood39: 804, 1972
Moore MAS, Metcalf D: Ontogeny of haemopoietic system: Yolk sac origin of in vivoand in vitrocolony forming cells in the developing mouse embryo. Br J Haematol18: 279, 1970
Quesenberry PJ, Morley A, Ryan M, Howard D, Stohlman F, Jr: The effect of endotoxin on murine stem cells. J Cell Physiol82: 239, 1973
Quesenberry PJ, Levin J, Zuckerman K, Rencricca N, Sullivan R, Tyler W: Stem cell migration induced by erythropoietin or haemolytic anemia: The effects of actinomycin and endotoxin contamination of erythropoietin preparation. Br J Haematol41: 253, 1979
Rencricca NJ, Rizzoli V, Howard D, Stohlman F, Jr: Stem cell migration and proliferation during severe anemia. Blood36: 764, 1970
Rickard KA, Rencricca NJ, Shadduck RK, Monette, FC, Howard DE, Garrity Mand Stohlman F, Jr: Myeloid stem cell kinetics during erythropoietic stress. Br J Haematl20: 537, 1971
Siminovitch L, Till JE, McCulloch EA: Detective in colony-forming ability of marrow cells subjected to serial transplantation into irradiated mice. J Cell Comp Physiol64: 23, 1964
B. Differentiation and migration patterns of maturing non-lymphoid cells
Guerry D, Dale DC, Omine M, Pensy S, Wolff SM: Periodic hematopoiesis in human cyclic neutropenia. J Clin Invest52: 3220, 1973
C. Differentiation and migration patterns of maturing lymphocytes
Cooper MD, Velardi A, Calvert JE, Gathings WE, Kubagawa H: Generation of B-cell clones during ontogeny. In: Progress in Immunology V, edited by Yamamura Y, Tada T, Academic Press, New York, 603, 1983
Everett NB, Tyler (Caffery) RW Lymphopoiesis in the thymus and other tissues: Functional implications. Int Rev Cytol22: 205, 1967
LeDouarin N, Dieterlen-Lieve F, Oliver PD: Ontogeny of primary lymphoid organs and lymphoid stem cells. Am J Anat170: 261, 1984
Miller SC: Production and renewal of murine natural killer cells in the spleen and bone marrow. J Immunol129: 2282, 1982
Osmond DG: The origins, life spans and circulation of lymphocytes. In: Sixth Annual Leucocyte Culture Conference, edited by Schwartz MR, Academic Press, New York, 3, 1972
Owen JJT, Jordan RK, Robinson JH, Singh Y, Willcox HNA: In vitrostudies on the generation of lymphocyte diversity. Cold Spring Harbor Symp Quant Biol41: 129, 1977
Rouse RV, Reichert RA, Gallatin WM, Weissmann IL, Butcher EC: Localization of lymphocyte subpopulation in peripheral lymphoid organs: Directed lymphocyte migration and segregation into specific environments. Am J Anat170: 391, 1984
Sprent J: Recirculating lymphocytes. In: The lymphocyte: Structure and function. Vol. 5, edited by Marchalonis JJ, Marcel Dekker, New York. 43, 1977
D. Metastatic behavior
Greig RG, Koestler TP, Trainer DL, Corwin SP, Miles L, Kline T, Sweet R, Yokoyama S, Poste G: Tumorigenic and metastatic properties of `normal’ and ras-trnsfected NIH/ 3T3 cells. Proc Natl Acad Sci USA82: 3698, 1985
Poste G, Doll J, Fidler IJ: Interactions among clonal subpopulations affect stability of the metastatic phenotype in poly-clonal populations of B-16 melanoma cells. Proc Natl Acad Sci USA78: 6226, 1981
Sugarbaker EU: Patterns of metastasis in human malignancies. Cancer Biol Rev2: 235, 1981
Van Patten LM, Kram LKJ, Van Dierendonck HHC, et al.: Enhancement by drugs of metastatic lung nodule formation after intravenous tumor cell injection. Int J Cancer15: 588, 1975
E. Chronic granulocytic leukemia and polycythemia vera
Bartram CR: bcr rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia. J Exp Med 162:2175, 1985
Canellos GP: Chronic leukemias: In: Principles and Practice of OncologyDeVita VT, Jr, Hellman S, Rosenbey S, eds Philadelphia Lippincott, 1739–1752, 1985
Canellos GP, Griffin JD: Chronic granulocytic leukemia: The heterogeneity of stem cell differentiation within a single disease entity. Semin Oncol12: 281, 1985
Catovsky D: Ph’-positive acute leukemia and chronic granulocytic leukemia: one of the two diseases? (Annotation). Br J Haematol42: 493, 1979
Groffen J, Stephenson JR, Heisterkamp N, deKlein A, Bartram CR, Grosveld G: Philadelphia chromosomal breakpoints are clustered within a limited region - bcr -chromosome 22. Cell36: 93, 1984
Nitta M, Kato Y, Strife A, Wachter M, Fried J, Perez A, Jhanwar S, Duigou-Oserndorf R, Chaganti RSK, Clarkson B: Incidence of involvement of the band T lymphocyte lineage in chronic myelogenous leukemia. Blood66: 1053, 1985
Skassin AT: Pathology and morphology of chronic leukemias and related disorders. In: Neoplastic Diseases of the Blood, edited by Wiernick PH, Canellos, GP, Kyle RA, Schiffer CA, Edinburgh Churchill Livingstone, 19–49, 1985
F. Acute lymphoblastic leukemia
Azzarelli B, Mirkin LD, Goheen M, Muller J, Crockett C: The lepto-meningeal vein: A site of re-entry of leukemic cells into the systemic circulation. Cancer54: 133, 1984
Baum E, Nesbit M, Tilford D, Heyn R, Krivit W: Extent of disease in pediatric patients with acute lymphocyte leukemia experiencing an apparent isolated testicular relapse. Proc Am Soc Clin Oncol20: 435, 1979
Fernbach DJ: Natural history of acute leukemia. In: Clinical Pediatric Oncology, edited by Sutow WW, Fernbach DJ, Vietti TJ, St. Louis, Mosby, 1980
Freeman A, Brecher ML: Diagnosis and treatment of childhood acute lymphocytic leukemia. In: Neoplastic Diseases of the Blood, edited by Wiernik PH, Canellos GP, Kyle RA, Schiffer CA, Edinburgh Churchill Livingstone, 267, 1985
Herschfield MS, Kuntsberg J, Harden E, Moore JO, WhangPeng J, Haynes BF: Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2’-deoxycoformycin. Proc Natl Acad Sci USA81: 253, 1984
Mathe G, Schwarzenberg L, Mery AM, et al: Extensive histological and cytological survey of patients with acute leukemia in “complete remission.” Br Med J1: 640, 1966
Murphy SB, Stass S, Kalwinsky D, Rivera G: Phenotypic conversion of acute leukemia from T-lymphoblastic to myeloblastic induced by therapy with 21-deoxycoformycin. Brit J Haemat55: 285, 1983
Nocheles TF: The acute leukemias New York, Stratton, 1979
Simone JJ, Holland E, Johnston W: Fatalities during remission of childhood leukemia. Blood39: 759, 1972
G. Acute non-lymphocytic leukemia
Necheles TF: The Acute Leukemias, Stratton, 71, 1979
Wiernik PH: Diagnosis and treatment of acute nonlymphocytic leukemia. In: Neoplastic Diseases of the Blood, edited by Wiernik PH, Canellos GP, Kyle RA, Schiffer CA, Churchill Livingstone, 335, 1985
H. Hodgkin’s disease
DeVita VT, Jr, Jaffe ES, Hellman S: Hodgkin’s disease and the non-Hodgkin’s lymphomas. In: Cancer: Principles and Practice of Oncology, edited by DeVita VT, Jr, Hellman S, Rosenberg SS, Philadelphia Lippincott, 1623, 1985
Fisher RI, Bates SE, Bostick-Bruton F, Tuteja N, Diehl V: Neoplastic cells obtained from Hodgkin’s disease function as accessory cells for mitogen-induced human T cell proliferative responses. J Immunol132: 2672, 1984
Hecht TT, Longo DL, Cossman J, Bolen JB, Hsu S, Israel M, Fisher RI: Production and characterization of a monoclonal antibody that binds Reed-Sternberg cells. J Immunol134: 4231, 1985
Hsu S, Yang K, Jaffe ES: Phenotypic expression of Hodgkin’s and Reed-Sternberg cells in Hodgkin’s disease. Am J Pathol118: 209, 1985
Kadin ME: Possible origin of the Reed-Sternberg cell form an interdigitating reticulum cell. Cancer Treat Rep66: 601, 1982
Kaplan HS, Dorfman RF, Nelson TS, et al.: Staging laparotomy and splenectomy in Hodgkin’s disease: Analysis of indications and patterns of involvement in 285 consecutive, unselected patients. Natl Cancer Inst Monogr36: 291, 1973
Stein H, Mason DY, O’Connor N, Wainscoat J, Pallesen G, Gatter K, Falini B, Delsol G, Lemke H, Schwarting R, Lennert K: The expression of the Hodgkin’s disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid tissue. Blood66; 848, 1985
I. B cell CLL
Degan M, Maeda K: Differentiation of chronic lymphocytic leukemia cells after in vitrotreatments with Epstein-Barr virus or phorbol esters I Immunologic and morphologic studies Am J Hamatol17: 335, 1984
Dillman RO, Beauregard JC, Lea JW, Green MR, Sobol RE, Royston I: Chronic lymphocytic leukemia and other chronic lymphoid proliferations: Surface marker phenotypes and clinical correlations. J Clin Oncology1 (3): 190, 1983
McPhedran P, Heath CW, Jr: Acute leukemia occurring during chronic lymphocyte leukemia. J Hamatol35: 7, 1970
Trump DL, Mann RB, Phelps R et al.:[tichter’s syndrome: Diffuse histiocytic lymphoma in patients with chronic lymphocytic leukemia. A report of five cases and a review of the literature. Am J Med68: 539, 1980
J. Burkitt’s lymphoma
Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, Palmiter RD, Brinster RL: The c-myconcogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature318: 537, 1985
Cory S: Activation of cellular oncogenes in hemopoietic cells by chromosomal translocation. Adv Cancer Res47: 189–234, 1986
Klein G, Klein E: Immunol Today6: 208, 1985
Leder P: Translocations among antibody genes in human cancer. Science222: 765, 1983
Magrath J: Burkitt’s lymphoma: Clinical aspects and treatment. In: Diseases of the Lymphatic System, Diagnosis and Therapy, edited by Molander DW, Springer-Verlag, 103, 1983
Mann RB, Jaffe ES, Braylan RB et al.: Nonendemic Burkitt’s lymphoma: B cell tumor related to germinal centers. N Engl J Med295: 685, 1976
K. Follicular lymphomas
Cossman J, Neckers LM, Hsu S, Longo D, Jaffee ES: Low grade lymphomas: Expression of developmentally regulated B-cell antigens. Am J Pathol115 (1): 117, 1984
Jones SE, Fuks Z, Bull M, Kadin ME, Dorfman RF, Kaplan HS, Rosenberg SA, Kim H: Non-Hodgkin’s lymphoma. IV. Clinicopathologic correlation in 405 cases. Cancer31: 806, 1973
Kim H, Dorfman RF: Morphological studies of 84 untreated patients subjected to laparotomy for the staging of non-Hodgkin’s lymphomas. Cancer33: 657, 1974
Lennert K, Mohri N: Histopathology and diagnosis of non-Hodgkin’s lymphomas. In: Malignant Lymphomas, edited by Lennert K, Heidelberg Springer-Verlag, 111, 1978
Paryani SB, Hoppe RT, Cox RS, Colby TV, Rosenberg SA, Kaplan HS: Analysis of non-Hodgkin’s lymphomas with nodular and favorable histologies, stages I and II. Cancer52: 2300, 1983
Rudders RA, Ahl ET, Jr, Delellis RA, Bernstein S, Begg CB: Surface marker identification of small cleaved follicular cancer cell lymphomas with a highly favorable prognosis. Cancer Res42: 349, 1982
Spiro S, Galton DAG, Wilthshaw E, Lohmann RC: Follicular lymphoma: A survey of 75 cases with special reference to the syndrome resembling chronic lymphocytic leukemia. Brit J Cancer31, Suppl. II, 60, 1975
L. Intermediate and aggressive B cell lymphomas
Anderson T, Chabner BA, Young RC, Bernard CW, Garvin AJ, Simon RM, DeVita V, Jr: Malignant lymphoma. I. The histology and staging of 473 patients at the National Cancer Institute. Cancer50: 2699, 1982
Bunn PA, Jr, Schein PS, Banks PM, DeVita VT, Jr: Central nervous system complications in patients with diffuse histiocytic and undifferentiated lymphoma: Leukemia revisited. Blood47: 3, 1976
Chabner BA, Johnson RE, Young RC, Canellow GP, Hubbard SP, Johnson SK, DeVita VT, Jr: Sequential nonsurgical and surgical staging of non-Hodgkin’s lymphoma. Ann Int Med85: 149, 1976
Cossman J: Diffuse aggressive non-Hodgkin’s lymphoma. In: Surgical Pathology of the Lymph Nodes and Related Organs. edited by Jaffe ES, Philadelphia Saunders, 1985
Cossman J, Jaffe ES, Fisher RI: Immunologic phenotypes of diffuse, aggressive non-Hodgkin’s lymphomas. Cancer54: 1310, 1984
Horning SJ, Doggett RS, Warnke RA, Dorfman RF, Cox RS, Levy R: Clinical relevance of immunologic phenotype in diffuse large cell lymphoma. Blood63 (5): 1209, 1984
Jones R, Hubbard SM, Osborne C, Merrill J, Garvin J, Young R, DeVita Vt, Jr: Histologic conversions in non-Hodgkin’s lymphoma. Proc Am Fed Clin Res26: 437A, 1978
Osborne CK, Young RC, Garvin AJ, Simon RM, Bernard CW, Hubbard CW, DeVita VT, Jr: Nodular histiocytic lymphoma: An aggressive nodular lymphoma with potential for prolonged disease-free survival. Blood56: 98, 1980
Paryani S, Hoppe RT, Burket JS, Dawley D, Cox RS, Rosenberg SA, Kaplan JS: Ectalymphatic involvement in diffuse non-Hodgkin’s lymphoma. J Clin Oncol1: 682, 1983
Rudders RA, Delellis RA, Ahl ET, Jr, Bernstein S, Begg C: Adult non-Hodgkin’s lymphoma: Correlation of cell surface marker phenotype with prognosis, the new working formulation, and the Rappaport and Lukes-Collins histomorphologic schemes. Cancer52: 2289, 1983
Soul SH, Kapadia SB: Primary lymphoma of Waldeyenn’s ring. Cancer56: 157, 1985
Young RC, Howser DM, Anderson T, Fisher RI, Jaffe E, DeVita VT, Jr; Central nervous system complications of non-Hodgkin’s lymphoma. Am J Med66: 435, 1979
M. Hairy cell leukemia
Machii T, Kitani T: Similarities between IgG-bearing lymphocytes and hairy cells: cytologic and cytochemical studies. Blood64: 166, 1984
Turner A, Kjeldsberg CR: Hairy cell leukemia: A review. Medicine57: 477, 1978
Westbrook CA, Groopman JE, Golde DW: Hairy cell leukemia: Disease pattern and prognosis. Cancer54: 500, 1984
O. Alpha-heavy chain disease
Galian A, Lecestre MJ, Scotio J, et al.: Pathological study of alpha-chain disease, with special emphasis on evolution. Cancer39: 2081, 1977
Stoop JW, Bullieux RE, Higmens W, et al.: Alpha-chain disease with involvement of the respiratory tract in a Dutch child. Clin Exp Immunol. 9: 625, 1971
Tabban S, Tabbane F, Cammoun M, et alp Mediterranean lymphomas with alpha-heavy chain monoclonal gammapathy. Cancer38: 1989, 1976
P. Multiple myeloma
Bergsagel DE, Rider WD: Plasma cell neoplasms. In: Cancer: Principles and Practice of Oncology, edited by DeVita VT, Jr, Hellman S, Rosenberg SA, Philadelphia Lippincott, 1753, 1985
Kubagawa H, Voglen LB, Lowton AR, Cooper MD: The extent of clonal involvement in multiple myeloma. In: Progress in Myelomaedited by Potter M, Amsterdam Elsevier, North-Holland, 195, 1980
Longo DL, Broder S: Plasma cell disorders. Harrison’s Textbook of Medicine, edited by Braunwald E, McGraw Hill, 1396, 1987.
Q. Lymphoblastic lymphoma
Cossman J, Chused TM, Fisher RI, Magrath I, Bollum F, Jaffe ES: Diversity of immunological phenotypes of lymphoblastic lymphoma. Cancer Res, 43: 4486, 1983
Magrath I: Malignant lymphomas. In: Cancer in the Young. edited by Levine AS, Masson Pub., 473, 1982
Nathwani BN, Diamond LW, Winberg CD, Kim H, Bearman RM, Glick JH, Jones SE, Gams RA, Nissen NI, Rappaport H: Lymphoblastic lymphoma: A clinical pathologic study of 95 patients. Cancer48: 2347, 1981
Catovsky D, Linch DC, Beverley PC: T cell disorders in haematological diseases. Clin Haematol. 11 (3): 661, 1982
Jaffe ES: Post-thymic lymphoid neoplasia. In: Surgical Pathology of the Lymph Nodes and Related Organs. edited by Jaffe ES, Philadelphia Saunders 218, 1985
R. T cell CLL
Brouet JC, Seligmann M: T-derived chronic lymphocytic leukemia. Path Research and Pract. 171: 262, 1981
Galton DAG, Goldman JM, Wiltshaw E, Catovsky D, Henry K, Goldberg GJ: Prolymphocytic leukemia. Br J Haematol. 27: 7, 1974
Pandolfo F, DeRossi G, Semenzato G, Quinti I, Ranucci A, De Sanctis G, Lopez M, Gasparotto G, Aiuti F: Immunologic evaluatiion of T chronic lymphocytic leukemia cells: Correlations among phenotype, functional activities and morphology. Blood59 (4): 688, 1982
S. Cutaneous T cell lymphoma
Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Ntl Acad Sci USA77: 7415, 1980
Winkler CF, Bunn PA, Jr: Cutaneous T-cell lymphoma: A review. CRC Crit. Rev. Onc/Hema.1 (1): 49, 1983
Wood GS, Deneau DG, Miller RA, Levy R, Hoppe R, Warnke RA: Subtypes of cutaneous T-cell lymphoma defined by expression of Leu-1 and Ia. Blood59 (5): 876, 1982
T. Peripheral Post-thymic T-cell lymphomas
Jaffe ES, Cossman J, Fisher RI: Immunologic, pathologic and clinical analysis of peripheral T-cell lymphomas. Blood58 (Suppl. 1 ): 160a, 1981
U. Adult T cell leukemia’ lymphoma
Hamaoka M: Progress in adult T-cell leukemia research. Acta Pathol. Jpn.32 (Suppl. 1): 171, 1982
Jaffe ES, Blattner WA, Blayney DW, Bunn PA, Cossman J, Robert-Guroff M, Gallo RC: The pathologic spectrum of adult T cell leukemia/lymphoma in the United States. Am J Surg Pathol8: 263, 1984
Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Jr, Minna JD, Gallo RC: Detection and isolation of type-C retrovirus particles form from fresh cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci. USA 77: 7415, 1980
Seiki M, Eddy R, Shrows TB, Yoshida M: Non-specific integration of the HTLV provirus genome into adult T-cell leukemia cells. Nature309: 640, 1984
Takatsuki K, Uchiyama T, Ueshima Y, Itattori T, Toibana T, Tsudo M, Wano R, Yodoi J: Adult T cell leukemia; Proposal as a new disease and cytogenetic, phenotypic and functional studies of leukemic cells. In: Adult T cell leukemia and related diseases. Japan Sci. Soc. Press/Plenum edited by Hamaoka M, Takatsuki K, Shimoyama M, 13, 1982
Urba WJ, Longo DL: Clinical spectrum of human retroviralinduced diseases. Cancer Res. 45: 4637s, 1985
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Kluwer Academic Publishers
About this chapter
Cite this chapter
Groves, E.S., Longo, D.L. (1989). Progression of Lymphoproliferative Disorders and Hematologic Malignancies. In: Brunson, K.W. (eds) Local Invasion and Spread of Cancer. Cancer Growth and Progression, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1093-5_10
Download citation
DOI: https://doi.org/10.1007/978-94-009-1093-5_10
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6982-3
Online ISBN: 978-94-009-1093-5
eBook Packages: Springer Book Archive