Etiology, Morphology and Pathogenesis of Proliferative and Hyperplastic Lesions and Neoplasms of Mouse Mammary Gland

  • Bernard Sass
Part of the Cancer Growth and Progression book series (CAGP, volume 5)


Apolant, in 1906 (3) described focal hypertrophic lesions of the mouse mammary gland which he felt resembled adenomas and which were later classified as hyperplastic alveolar lesions. Haaland, in 1911 (36) reported the existence of hyperplastic changes which preceded neoplasia and also showed that increased frequency of hyperplastic mammary gland lesions in mice was related to both increasing age and the subsequent occurrence of cancer. Murray, in 1911 (75) discovered a hereditary factor in the etiology of mouse mammary tumors.


Mammary Gland Mammary Tumor Mouse Mammary Tumor Virus Mouse Mammary Gland Preneoplastic Lesion 
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  1. 1.
    Aidells BD, Daniel CW: Hormone-dependent mammary tumors in strain GR/A mice. Alternation between ductal and tumorous phases of growth during serial transplantation. JNCI 52:1855–1863, 1974.PubMedGoogle Scholar
  2. 2.
    Andervont HB, Dunn TB: Response of strain, DBA/2f mice, without the mammary tumor agent, to oral administration of methylcholanthrene. JNCI 14:329–339, 1953.PubMedGoogle Scholar
  3. 3.
    Apolant H : Die epithelialen Geschwülste der Maus. Arbeiten aus dem Königlichen Institut für experimentelle Therapie zu Frankfurt- a.M. 11–62, 1906. Google Scholar
  4. 4.
    Arthur LO, Fine DL, Bentvelzen P: Oncogenicity of murine mammary tumor virus produced in tissue culture: Brief communication. JNCI 60:461–464, 1978.PubMedGoogle Scholar
  5. 5.
    Asch BB, Medina D: Concanavalin A-induced agglutinability of normal, preneoplastic and neoplastic mouse mammary cells. JNCI 61:1423–1430, 1978.PubMedGoogle Scholar
  6. 6.
    Banerjee MR, Wood BG, Washburn LL: Chemical car- cinogen-induced alveolar nodules in organ culture of mouse mammary gland. JNCI 53:1387–1393, 1974.PubMedGoogle Scholar
  7. 7.
    Berenblum I: A speculative review: The probable nature of promoter action and its significance in the understanding of the mechanism of carcinogenesis. Cancer Res 14:471–477, 1954.PubMedGoogle Scholar
  8. 8.
    Berenblum I : “Carcinogenesis: Mechanisms of Action”. pp. 55–64, Edited by: G.E.W. Wolstenholme and M. O’Connor Little, Brown Boston, Mass, 1958.Google Scholar
  9. 9.
    Berenblum I : “Cellular Control Mechanisms and Cancer”. pp. 259–267, Edited by: P. Emmelot and O. Muhlbock, Elsevier, Amsterdam, 1964.Google Scholar
  10. 10.
    Bern HA, Nandi S: Recent studies of the hormonal influence in mouse mammary tumorigenesis. Prog Exp Tumor Res 2:91–145, 1961.Google Scholar
  11. 11.
    Bern HA, Nandi S, Finster V: Induction of Lactation in precancerous hyperplastic alveolar nodules in the mammary gland of C3H HeCrgl mice. Experientia 15:155–157, 1959.PubMedCrossRefGoogle Scholar
  12. 12.
    Bernhard W, Granboulan N: “Tumor viruses of murine origin”. pp. 6–49. Edited by: G.E.W. Wolstenholme and M. O’Connor. Churchill, London, 1962.Google Scholar
  13. 13.
    Biancifiori C, Caschera F: The relation between pseudopreg- nancy and the chemical induction by four carcinogens of mammary and ovarian tumors in BALB/c mice. Br J Cancer 16:722–730, 1962.PubMedCrossRefGoogle Scholar
  14. 14.
    Bittner JJ: Some enigmas associated with the genesis of mammary cancer in mice. Cancer Res 8:625–639, 1948.PubMedGoogle Scholar
  15. 15.
    Bonser GM: The evolution of mammary cancer induced in virgin female IF mice and minimal doses of locally-acting methylcholanthrene. J Pathol Bacteriol 68:531–546, 1954.PubMedCrossRefGoogle Scholar
  16. 16.
    Bonser GM : The mammary changes in IF female mice following a limited dose of four carcinogenic chemicals. Int Symp Mammary Cancer Proc, 2nd, 1957, pp. 576–584, 1958.Google Scholar
  17. 17.
    Dalton AJ, Felix MD: The electron microscopy of normal and malignant cells. Ann NY Acad Sci 63:1117–1140, 1956.PubMedCrossRefGoogle Scholar
  18. 18.
    Dalton AJ, Potter M, Merwin RM: Some ultrastructural characteristics of a series of primary and transplanted plasma cell tumors of the mouse. JNCI 26:1221–1268, 1961.PubMedGoogle Scholar
  19. 19.
    de Harven E, Friend C: Electron microscopic study of a cell free induced leukemia of the mouse. A preliminary report. J Biophysics Biochem Cytol 4:151–156, 1958.CrossRefGoogle Scholar
  20. 20.
    DeOme KB, Bern HA, Nandi S, Pitelka D, Faulkin CJ Jr: The precancerous nature of the hyperplastic alveolar nodules found in the mammary glands of old female. C3H/HeCrgl mice in: Genetics and Cancer, pp. 327–248. U. of Texas Press, 1959.Google Scholar
  21. 21.
    DeOme KB, Faulkin LJ Jr, Bern HA, Blair PE: Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res 19:515–520, 1959.PubMedGoogle Scholar
  22. 22.
    DeOme KB, Blair PB, Faulkin CJ Jr: Some characteristics of the preneoplastic-hyperplastic alveolar nodules of C3H/Crgl mice. Acta Unio Contre le Cancer. 17:973–982, 1961.Google Scholar
  23. 23.
    DeOme KB, Nandi S, Bern HA, Blair PB, Pitelka DR: Morphological precursor of cancer, pp. 349–368, edited by Lucio Severi. Div of Cancer Res Perugia, 1962.Google Scholar
  24. 24.
    Dmochowski L, Grey CE: Electron microscopy of known and suspected viral etiology. Tex Repts Biol and Med 15:704–753.Google Scholar
  25. 25.
    Dunn TB : Morphology of Mammary tumors in mice. In: “The Physiopathology of Cancer” pp. 38–84. Edited by: F. Homburger. Harper (Hoeber) New York, 1957.Google Scholar
  26. 26.
    Faulkin LJ Jr: Hyperplastic lesions of mouse mammary glands after treatment with 3-methylcholanthrene. JNCI 36:289–298, 1966.PubMedGoogle Scholar
  27. 27.
    Fekete EA: A comparative morphological study of the mammary gland in a high and low incidence tumor strain of mice. Am J of Pathol 14:557–578, 1938.Google Scholar
  28. 28.
    Feldman MK: Decreased serum responsiveness by primary cultures of preneoplastic and neoplastic mammary epithelial cells. Experientia 15:97–98, 1978.CrossRefGoogle Scholar
  29. 29.
    Foulds L: Mammary tumors in hybrid mice: Growth and progression of spontaneous tumors. Br J Cancer 3:345–375, 1949.PubMedCrossRefGoogle Scholar
  30. 30.
    Foulds L: The histologic analysis of mammary tumors in mice. JNCI 17:701–801, 1956.PubMedGoogle Scholar
  31. 31.
    Foulds L : In: Cellular control mechanisms and cancer. Edited by P. Emmelot and O. Muhlbock, pp. 242–258. Elsevier, Amsterdam, 1964.Google Scholar
  32. 32.
    Foulds L : Neoplastic development. Vol. 1 pp. 24–81. Academic Press, London, 1969.Google Scholar
  33. 33.
    Friedewald WF, Rous P: The initiating and promoting elements in tumor production. An analysis of the effect of tar, benzol and pyrene and methylcholanthrene on rabbit skin. J Expt Med 80:101–128, 1944.CrossRefGoogle Scholar
  34. 34.
    Friedewald WF, Rous P: Pathogenesis of deferred cancer; study of the after-effects of methylcholanthrene upon the rabbit skin. J Exptl Med 91:459–484, 1950.CrossRefGoogle Scholar
  35. 35.
    Gardner WU, Strong LC, Smith GM: The mammary glands of mature female mice of strains varying in susceptibility to spontaneous tumor development. Am J Cancer 33:510–517, 1939.Google Scholar
  36. 36.
    Haaland M : “Spontaneous tumors in mice”. In: Fourth Scientific Report, pp. 1–111. Imperial Cancer Research Fund London, 1911.Google Scholar
  37. 37.
    Harbell JW, Daniel CW: Induction of the GR pregnancy- dependent mammary tumors by hormones in vitro (meeting abstract). In Vitro 14:361, 1978.Google Scholar
  38. 38.
    Haran-Ghera N: The mechanism of carcinogenesis in breast tumor development in mice. Acta Unio Contra Cancrum 19:765–768, 1963.Google Scholar
  39. 39.
    Harkness MN, Bern HA, Alfert M, Goldstein NO: Cyto- chemical studies of hyperplastic alveolar nodules in the mammary gland. JNCI 19:1023–1033, 1957.PubMedGoogle Scholar
  40. 40.
    Heston WE, Vlahakis G, Tsubura Y: Strain DD, a new high mammary tumor strain and comparison of DD with strain C3H. JNCI 32:237–251, 1964.PubMedGoogle Scholar
  41. 41.
    Highman B, Norvell MJ, Shellenberger TE: Pathological changes in female C3H mice continuously fed diets containing diethylstilbestrol or 17 B-estradiol. J Environ Pathol Toxicol 1:1–30, 1977.Google Scholar
  42. 42.
    Hilgers J, Bentvelzen P: Interactions between viral and genetic factors in mouse mammary cancer. Adv Cancer Res 29:143–195, 1978.CrossRefGoogle Scholar
  43. 43.
    Hosick HL, Angello JC, Anderson ME: Stimulation of mammary epithelial growth by free fatty acids and changes in this response during neoplastic progression (meeting abstract) Proc Am Assoc Cancer Res 19, 178, 1978.Google Scholar
  44. 44.
    Huseby RA, Bittner JJ: A comparative morphological study of the mammary glands with reference to the known factors influencing the development of mammary carcinoma in mice. Cancer Res 6:240–255, 1946.PubMedGoogle Scholar
  45. 45.
    Ingraham RL: Variability of mouse mammary hyperplastic nodules maintained in organotypic culture. JNCI 40:1273–1286, 1968.PubMedGoogle Scholar
  46. 46.
    Iyer AP, Banerjee MR: Sequential expression of preneoplastic and neoplastic characteristics of mouse mammary epithelial cells transformed in organ culture. JNCI 66:893–905, 1981.PubMedGoogle Scholar
  47. 47.
    Jones EE: A comparative study of hyperplastic nodules in mammary glands of mice with and without the mammary inciter. Acta Unio Contra Cancrum 7:262–265, 1951.Google Scholar
  48. 48.
    Jones EE: Studies on the mammary glands of hybrid mice theoretically free of the milk agent. Acta Unio Contra Cancrum 12:638–652, 1956.Google Scholar
  49. 49.
    Kawashima S, Bern HA, Jones LA, Mills KT: Histometric study of the pituitary in mice treated neonatally with steroids and the relationship between prolactin cells and mammary tumorigenesis. Endocrinol Japan 25:341–348, 1978.Google Scholar
  50. 50.
    Krarup T: Effect of 9,10-dimethyl-l,2-benzanthracene on the mouse ovary. Br J Cancer 24:168–186, 1970.PubMedCrossRefGoogle Scholar
  51. 51.
    Lathrop AEC, Loeb L: Further investigations on the origins of tumors in mice. On the part played by hormones in spontaneous development of tumors. J Cancer Res 1:1–20, 1916.Google Scholar
  52. 52.
    Lennox B : Some relationships between tumours of the breast and the sweat glands. In: “The Morphological Precursor of Cancer” pp. 423–428 (Ed.) L. Severi, Division of Cancer Research, Perugia, 1962.Google Scholar
  53. 53.
    Liebelt AG, Liebelt RA: Chemical factors in mammary tumorigenesis. Annu Symp Fundam Cancer Res [Proc] 20:315–345, 1967.Google Scholar
  54. 54.
    Lin FL, Banerjee MR, Crump LR: Cell cycle related hormone carcinogen interaction during chemical carcinogen induction of nodule-like mammary lesions in organ culture. Cancer Res 36:1607–1614, 1976.PubMedGoogle Scholar
  55. 55.
    Lorenz E, Jacobson LO, Heston WE, Shimkin M, Eschen- brenner AB, Deringer MK, Donniger J, Schweisthal R: In: “Biological Effects of External X and Gamma Radiation”. Pt. 1, chapter 5, p. 207. Edited by Zirkel RE. McGraw-Hill, New York, 1954.Google Scholar
  56. 56.
    McGrath CM: Replication of mammary tumor virus in tumor cell cultures: dependence on hormone-induced cellular organization. JNCI 47:455–467, 1971.PubMedGoogle Scholar
  57. 57.
    Medina D: Preneoplastic lesions in mouse mammary tumorigenesis. Methods Cancer Res 7:353–414, 1973.Google Scholar
  58. 58.
    Medina D : Mammary tumorigenesis in chemical carcinogen- treated mice. 1. Incidence in BALB/c and C57BL mice. JNCI 53:213–221, 1974.PubMedGoogle Scholar
  59. 59.
    Medina D: Mammary tumorigenesis in chemical carcinogen- treated mice. II. Dependence on hormone stimulation for tumorigenesis. JNCI 53:223–226, 1974b.Google Scholar
  60. 60.
    Medina D: Preneoplastic lesions in murine mammary cancer. Cancer Res 36:2589–2595, 1976a.PubMedGoogle Scholar
  61. 61.
    Medina D: Mammary tumorigenesis in chemical carcinogen- treated mice. VI. Tumor-producing capabilities of mammary dysplasias in BALB/cCgl mice. JNCI 57:1185–1189, 1976b.Google Scholar
  62. 62.
    Medina D : Mammary Tumors. In: “The Mouse in Biomedical Research”. Vol. IV, pp. 373–396. Edited by Foster, M.L., Small, J.D., and Fox, J.G. Academic Press, New York, 1982.Google Scholar
  63. 63.
    Medina D, DeOme KB: Influence of mammary tumor virus on the tumor-producing capabilities of nodule outgrowths free of mammary tumor virus. JNCI 40:1303–1308, 1968.PubMedGoogle Scholar
  64. 64.
    Medina D, DeOme KB: Effects of various oncogenic agents on tumor-producing capabilities of D series BALB/c mammary nodule outgrowth lines. JNCI 45:353–363, 1970.PubMedGoogle Scholar
  65. 65.
    Medina D, Shepherd F: Enhancement and inhibition of mammary tumor formation and growth by cytostatic drugs. Cancer Res 37:3571–3577, 1977.PubMedGoogle Scholar
  66. 66.
    Medina D, Warner M: Mammary tumorigenesis in chemical carcinogen-treated mice. IV. Induction of mammary ductal hyperplasias. JNCI 57:331–337, 1976.Google Scholar
  67. 67.
    Medina D, Bern HA, Brown D, DeOme KB: Mammary tumor virus activity in mammary tissues of hormone stimulated BALB/cfC3H, Crgl mice. Proc Soc Exp Biol Med 131:180–183, 1969.Google Scholar
  68. 68.
    Medina D, DeOme KB, Pitelka DR, Colley VB: Appearance of virus particles in BALB/c mammary nodule outgrowth lines transplanted into BALB/cfC3H and (C3hXBALB/c)F1 mice. JNCI 46:1153–1160, 1971.PubMedGoogle Scholar
  69. 69.
    Medina D, Butel JS, Socher SH, Miller FL: Mammary tumorigenesis in 7,12 dimethylbenzanthracene treated (C57BLxDBA/20F! mice. Cancer Res 40, 368–373, 1980a.PubMedGoogle Scholar
  70. 70.
    Medina D, Asch BB, Brinkley BR, Mace ML: In vitro and in vivo models for transformation of breast cells. Breast Cancer: “New Concepts in Etiology and Control”. pp. 53–66. Edited by M.J. Brennan, C.M. McGrath, M.A. Rich. Academic Press, New York, 1980b.Google Scholar
  71. 71.
    Michalides R, Van Deemter L, Nusse R, Ropcke G, Boot L: Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low mammary tumor mouse strains. J Virol 27, 551–559, 1978.PubMedGoogle Scholar
  72. 72.
    Mottram JC: A developing factor in experimental his-togenesis. J Pathol Bact 56:181–187, 1944.CrossRefGoogle Scholar
  73. 73.
    Muhlbock O, Bentvelzen P: The transmission of the mouse mammary tumor viruses. Persp in Virol 6:75–87, 1969.Google Scholar
  74. 74.
    Muhlbock O, Tengbergen EW van: Studies on the development of mammary tumors in dilute-brown DBA/s mice without the agent. JNCI 13:505–532, 1952.PubMedGoogle Scholar
  75. 75.
    Murray JA: Cancerous ancestry and the incidence of cancer in mice. Scient Rep Invest Imp Cancer Res Fund 4:114–130, 1911.Google Scholar
  76. 76.
    Nagle SC, Fine DL: Demonstration of components of serum- free culture medium effecting maximum in vitro expression of mouse mammary tumor virus. In Vitro 14 (2), 218–226, 1979.CrossRefGoogle Scholar
  77. 77.
    Nandi S: A new method for detecting mouse mammary tumor virus I Influence of foster nursing on incidence of hyperplastic mammary nodules in BALB/cCrgl mice. JNCI 25:753–778, 1963a.Google Scholar
  78. 78.
    Nandi S: A new method for detection of mouse mammary tumor virus. II. Effect of administering lactating tissue extracts on the incidence of HAN in BALB/cCrgl mice. JNCI 31:75–89, 1963b.Google Scholar
  79. 79.
    Nandi S : Interactions among hormonal, viral and genetic factors in mouse tumorigenesis. Can Cancer Conf 6:69–81.Google Scholar
  80. 80.
    Nandi S, MCGrath CS: Mammary neoplasia in mice. Adv Cancer Res 17:353–414, 1973.CrossRefGoogle Scholar
  81. 81.
    Parks WP, Scolnick EM, EH: Dexamethasone stimulation of murine mammary tumor virus expression: A tissue culture source of virus. Science 184:158–160, 1974Google Scholar
  82. 82.
    Pauley RJ, Medina D, Socher SH: Murine mammary tumor virus expression during mammary tumorigenesis in BALB/c mice. J Virol 29:483–493, 1979.PubMedGoogle Scholar
  83. 83.
    Pitelka DR, Bern HA, DeOme KB, Schooley CN, Wellings SR: Virus like particles in hyperplastic alveolar nodules of the mammary gland of the C3H/He mouse. JNCI 20:541–554, 1958.PubMedGoogle Scholar
  84. 84.
    Pitelka DR, DeOme KB, Bern HA, Nandi S: On the significance of virus-like particles in mammary tissues of C3Hf mice. JNCI 33:867–885, 1958.Google Scholar
  85. 85.
    Pitelka DR, Unemori EN, Field MF et al Cell-cell and cell-stroma interactions in Metastasis. In: Understanding Breast Cancer: Clinical and Laboratory Concepts. Rich MA, Hager JC, Furmanski P (eds). New York, Marcel Dekker, pp. 99–118, 1983.Google Scholar
  86. 86.
    Pitelka DR, DeOme KB, Bern HA: Virus-like particles in precancerous hyperplastic mammary tissues of C3H and C3Hf mice. JNCI 25:753–778, 1960.PubMedGoogle Scholar
  87. 87.
    Ranadive KB, Hakim SA: The chemical induction of mammary cancer in different inbred strains of mice. Int Symp Mammary Cancer Proc, 2nd 1957, pp. 575–584, 1958.Google Scholar
  88. 88.
    Rous P, Kidd JG: Conditional Neoplasms and subthreshold states. A study of the tar tumor of rabbits. Expt Med 73:365–389, 1941.Google Scholar
  89. 89.
    Rudali G, Julline P, Nives C, Apiou F: Dose-effect studies on estrogen induced mammary cancer in mice. Biomedicine 29:45–46, 1978.PubMedGoogle Scholar
  90. 90.
    Ruppert B, Wei W, Medina D, Medina GH: Effect of chemi cal-carcinogen treatment on the immunogenicity of mouse mammary tumors arising from hyperplastic alveolar outgrowth lines. JNCI 61:1165–1169, 1978.PubMedGoogle Scholar
  91. 91.
    Sarkar NH, Nowinski RC, Moore DH: Characteristics of structural components of the mouse mammary tumor virus. I. Morphological and Biochemical Studies. Virol 46:1, 1971.Google Scholar
  92. 92.
    Sass B, Dunn TB: Classification of mouse mammary tumors in Dunn’s miscellaneous group including recently reported types. JNCI 62:1287–1293, 1979.PubMedGoogle Scholar
  93. 93.
    Sass B, Vlahakis G, Heston WE: Precursor lesions and pathogenesis of spontaneous mammary tumors in mice. Toxicologic Path 10:12–21, 1982.CrossRefGoogle Scholar
  94. 94.
    Schaefer FV, Tonelli QJ, Dickens MS, Custer RP, Sorof S: Nononcogenic hormone-independent alveoli produced by carcinogens in cultured mouse mammary glands. Cancer Research 43:3310–3315, 1983.PubMedGoogle Scholar
  95. 95.
    Schlom J, Hand PH, Teramoto YA, Callahan R, Topdaro G, Schidlorsky G; Characterization of a new virus from MUS cervicolor immunologically related to the mouse mammary tumor virus. JNCI 61:1509–1519, 1978.PubMedGoogle Scholar
  96. 96.
    Singh DV, DeOme KB, Bern HA: Strain differences in re¬sponse to the mouse mammary gland to hormones in vitro. JNCI 45:657–675, 1970.PubMedGoogle Scholar
  97. 97.
    Slemmer G: Interactions of separate types of cells during normal and neoplastic gland growth. J Invest Dermtol 63:27–47, 1974.CrossRefGoogle Scholar
  98. 98.
    Smith GH, Pauley RJ, Socher SH, Medina D: Chemical carcinogenesis in C3H/StWi mice. A worthwhile experimental model for breast cancer. Cancer Res 38:4504–4509, 1978.Google Scholar
  99. 99.
    Squartini F: Mammogenesis and breast carcinogenesis in virgin female mice of BALB/cf substrain with the milk agent. JNCI 23:1227–1238, 1959.PubMedGoogle Scholar
  100. 100.
    Squartini F, Bistocchi M: Bioactivity of C3H and RIII mammary tumor viruses in virgin female BALB/c mice. JNCI 58:1845–1847, 1977.PubMedGoogle Scholar
  101. 101.
    Squartini F, Bistocchi M, Buongiorno L: Development, morphology and progression of mammary tumors during and after fertile life in BALB/cfRIII mice. JNCI 66 311–319,1981.PubMedGoogle Scholar
  102. 102.
    Strum J: Pale cell carcinoma-ultrastructure of a hormone dependent mammary tumor in GR mice. Am J Path 103:283–291, 1981.PubMedGoogle Scholar
  103. 103.
    Stjernsward J: Immunodepressive effect of 3-methyl- cholanthrene: Antibody formation at the cellular level and reaction against weak antigenic homografts. JNCI 35:885–892, 1965.PubMedGoogle Scholar
  104. 104.
    Swartz-Dusing SD, Medina D, Butel JS, Socher SH: Mouse mammary tumor virus genome expression in chemical carcinogen-induced mammary tumors in a low and high tumor incidence mouse strain. Proc Natl Acad Sci USA 76:5360–5364, 1979.CrossRefGoogle Scholar
  105. 105.
    Taylor HC Jr, Waltman CA: Hyperplasia of mammary gland in human and in the mouse; morphological and etiological contrasts. Arch surg 40:733–840, 1940.Google Scholar
  106. 106.
    Tonelli QJ, Custer RP, Sorof S: Transformation of cultured mouse mammary glands by aromatic amines and amides and their derivatives. Cancer Res 39:1784–1792, 1979.PubMedGoogle Scholar
  107. 107.
    Ullrich RL, Jernigan MC, Storer JB: Neutron car-cinogenesis: Dose and dose-rate effects in BALB/c mice. Radiat Res 72:487–498, 1977.PubMedCrossRefGoogle Scholar
  108. 108.
    van Gulik PJ, Korteweg R: The anatomy of mammary gland in mice in regard to the degree of its disposition for cancer. Neth Akad Wettenschappen 43:891–900, 1940.Google Scholar
  109. 109.
    vanNie R, Dux A: Biological and morphological characteristics of mammary tumors in GR mice. JNCI 46:885–897, 1971.Google Scholar
  110. 110.
    Vlahakis G, Heston WE, Smith GH: Strain C3H/AvyfB mice: Ninety percent incidence of mammary tumors transmitted by either parent. Science 170:185–187, 1970.PubMedCrossRefGoogle Scholar
  111. 111.
    Voyles BA, McGrath CM: Differential responses of malignant BALB/c mammary epithelial cells to the multiplication- stimulating activity of insulin. Cancer Res 62:597–605, 1979.Google Scholar
  112. 112.
    Wellings SR, Jensen HM: On the origin and progression of ductal carcinoma in the human breast. JNCI 50:1111–1118, 1973.PubMedGoogle Scholar
  113. 113.
    Wellings SR, Jensen HM, Marcum RG: An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. JNCI 55:231–273, 1975.PubMedGoogle Scholar
  114. 114.
    Welsch CW, Gribler C: Prophylaxis of spontaneously developing mammary carcinoma in C3H/HeJ female mice by suppression of prolactin. Cancer Res 33:2939–2946, 1973.PubMedGoogle Scholar
  115. 115.
    Welsch CW: Prophylaxis of early preneoplastic lesion of the mammary gland. Cancer Res 36:2621–2625, 1976.PubMedGoogle Scholar
  116. 116.
    Yagi MJ: Cultivation and characterization of BALB/cfC3H mammary tumor cell lines. JNCI 51:1849, 1973.PubMedGoogle Scholar
  117. 117.
    Yanai R, Nagasawa H: Development and growth of pregnancy-dependent and - independent mammary tumors in GR/A strain of mice and their interrelationship. GANN 69:25–30, 1978.PubMedGoogle Scholar
  118. 118.
    Yanai R, Mori T, Nagasawa H: Long-term effects of prenatal and neonatal administration of 5-beta-dihydrotestosterone on normal, and neoplastic mammary development in mice. Cancer Res 37:4566–4459, 1997.Google Scholar
  119. 119.
    Youn LJT, Cardiff RD, Ashley RL: Long-term primary culture of mouse mammary tumor cells: Production of virus. JNCI 54:1215–1221, 1975.Google Scholar

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  • Bernard Sass

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