Skip to main content
SpringerLink
Log in

Hemoperfusion

  • Chapter
Replacement of Renal Function by Dialysis

Abstract

Treatment of chronic uremia has focused on reducing the generation of nitrogenous end products of protein breakdown, or on their removal by dialysis techniques. Treatment of many thousands of patients with chronic uremia has demonstrated that diet and dialysis can sustain life, although they do not correct all the metabolic consequences of renal failure and many features of uremia continue unabated. Attention has been directed over the last two decades to the properties of sorbents in an attempt to increase the efficiency of the dialysis technique. Oral sorbents such as oxystarch and charcoal, have been of considerable interest, but as yet remain of unproven value as the sole treatment for severe uremia. However, sorbent regeneration of dialysate (see Chapter 19), is now accepted in the clinical management of uremia. This chapter will deal with direct contact of blood with sorbents within cartridges (columns), primarily reviewing the potential use of hemoperfusion in uremia, but also discussing the application of hemoperfusion in drug intoxication, hepatic encephalopathy, and other potential uses (Figure 1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Yatzidis H: A convenient haemoperfusion micro-apparatus over charcoal for the treatment of endogenous and exogenous intoxications. Its use as an artificial kidney. Proc Eur Dial Transplant Assoc 1: 83, 1964

    Google Scholar 

  2. Dunea G, Kolff WJ: Clinical experience with the Yatzidis charcoal artificial kidney. Trans Am Soc Artif Intern Organs 11: 178, 1965

    PubMed  CAS  Google Scholar 

  3. Chang TMS: Semipermeable aqueous microcapsules (artifical cells): with emphasis on experiments in an extracorporeal shunt system. Trans Am Soc Artif Intern Organs 12: 13, 1966

    PubMed  CAS  Google Scholar 

  4. Asher WJ: Introduction to sorbents. in Sorbents and Their Clinical Applications edited by Giordano C, New York, Academic Press Inc, 1980, p 3

    Google Scholar 

  5. Denti E, Walker JM: Activated carbon: properties, selection and evaluation, in Sorbents and Their Clinical Applications edited by Giordano C, New York, Academic Press Inc, 1980, p101

    Google Scholar 

  6. Denti E, Luboz MP, Tessore V: Adsorption characteristics of cellulose acetate coated charcoals. J Biomed Mater Res 9: 143, 1975

    PubMed  CAS  Google Scholar 

  7. Winchester JF, Ratcliffe JG, Carlyle E, Kennedy AC: Solute, amino acid, and hormone changes with coated charcoal hemoperfusion in uremia. Kidney Int 14: 74, 1978

    PubMed  CAS  Google Scholar 

  8. Kokot F, Pietrek J, Seredynski M: Influence of haemoperfusion on plasma levels of hormones and B-methyldigoxin. Proc Eur Dial Transplant Assoc 15: 604, 1978

    PubMed  CAS  Google Scholar 

  9. Cornelis R, Ringoir S, Mees L, Hoste J: Behavior of trace metals during hemoperfusion.Miner Electrolyte Metab 4: 123, 1980

    CAS  Google Scholar 

  10. Hagstam KE, Larsson LE, Thysell H: Experimental studies on charcoal haemoperfusion in phenobarbital intoxication and uraemia, including histopathologic findings. Acta Med Scand 180: 593, 1966

    PubMed  CAS  Google Scholar 

  11. Winchester JF: Hemoperfusion in uremia, in:Sorbents and Thier Clinical Applications, edited by Giordano C, New York, Academic Press Inc, 1980, p 387

    Google Scholar 

  12. Chang TMS: Microcapsule artificial kidney in replacement of renal function. With emphasis on adsorbent hemoperfusion. in: Replacement of Renal Function by Dialysis First Edition, edited by Drukker W, Parsons FM, Maher JF, The Hague, Boston, London, Martinus Nijhoff, 1978, p 217

    Google Scholar 

  13. Odaka M, Tabata Y, Kobayashi H, Nomura Y, Soma M, Hirasawa H, Sato H, Suenaga E, Nabeta K: Three hour maintenance haemodialysis combining direct haemoperfusion and haemodialysis. Proc Eur Dial Transplant Assoc 13: 257, 1976.

    Google Scholar 

  14. Ota K, Ohta T, Kobayashi M, Yoshida S, Kaneko I, Agishi T, Sugihara M: Petroleum based activated charcoal for direct haemoperfusion. Proc Eur Dial Transplant Assoc 13: 250, 1976

    Google Scholar 

  15. Stefoni S, Feliciangeli G, Coli L, Bonomini V: Evaluation of a new coated charcoal for hemoperfusion in uremia.Int J Artif Organs 2: 320, 1979

    PubMed  CAS  Google Scholar 

  16. Craddock PR, Fehr J, Brigham KL, Kronenberg R, Jacobs HS: Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis. N Engl J Med 296: 769, 1977

    PubMed  CAS  Google Scholar 

  17. Pott G, Voss B, Lohmann J, Zundorf P: Loss of fibronectin in plasma of patients with shock and septicaemia, and after haemoperfusion in patients with severe poisoning. J Clin Chem Clin Biochem 20: 333, 1982

    PubMed  CAS  Google Scholar 

  18. Gurland HJ, Fernandez JC, Samtleben W, Castro LA: Sorbent membranes used in a conventional dialyzer format: In vitro and clinical evaluation. Artif Organs 2: 372, 1978

    PubMed  CAS  Google Scholar 

  19. Davis TA, Cowsar DR, Harrison SD, Tanquary AC: Artificial carbon fibers for hemoperfusion. Trans Am Soc Artif Intern Organs 20: 353, 1974

    Google Scholar 

  20. Malchesky PS, Varnes WG, Nokoff R, Nose Y: The charcoal capillary haemoperfusion system. Proc Eur Dial Transplant Assoc 13: 242, 1976

    Google Scholar 

  21. van Berlo AMW, Poelmans AP, van der Pols, Aarts PJM, Verkooyen AHM: Comparing in vitro adsorption studies with the filmadsorber and other haemoperfusion devices, in: Biomaterials in Artificial Organs, edited by Paul JP, Gaylor JDS, Courtney JM, Gilchrist T, London, Basingstoke, The Macmillan Press Ltd, 1984, p 155

    Google Scholar 

  22. Weston MJ, Langley PG, Rubin MH, Hanid MA, Mellon P, Williams R: Platelet function in fulminant hepatic failure and effect of charcoal haemoperfusion. Gut 18: 897, 1977

    PubMed  CAS  Google Scholar 

  23. Winchester JF, Forbes CD, Courtney JM, Reavey M, Prentice CRM: Effect of sulphinpyrazone and aspirin on platelet adhesion to activated charcoal and dialysis membranes in vitro. Thromb Res 11: 443, 1977

    PubMed  CAS  Google Scholar 

  24. Bunting S, Moncada S, Vane JR, Woods HF, Weston MJ: Prostacyclin improves haemocompatibility during charcoal haemoperfusion. in: Prostacyclin, edited by Vane JR, Bergstrom S, New York, Raven Press, 1979, p 361

    Google Scholar 

  25. Gimson AES, Langley PG, Hughes RD, Canalese J, Mellon PG, Williams R, Woods HF, Weston MJ: Prostaclyclin to prevent platelet activation during charcoal haemoperfusion in fulminant hepatic failure. Lancet 1: 173, 1980

    PubMed  CAS  Google Scholar 

  26. Gimson AES, Braude S, Mellon PJ, Canalese J, Williams R: Earlier charcoal haemoperfusion in fulminant hepatic failure. Lancet 2: 681, 1982

    PubMed  CAS  Google Scholar 

  27. Woods HF, Weston MJ, Bunting S, Moncada S, Vane J: Prostacyclin eliminates the thrombocytopenia associated with charcoal hemoperfusion and minimizes heparin and fibrinogen consumption. Artif Organs 4: 176, 1980

    PubMed  CAS  Google Scholar 

  28. Mauer S, Chavers BM, Kjellstrand CM: Treatment of an infant with severe chloramphenicol intoxication, using charcoal-column hemoperfusion. J Pediatr 96: 136, 1980

    PubMed  CAS  Google Scholar 

  29. Winchester JF:Evaluation of Sorbent Haemoperfusion in Poisoning and Uraemia. MD Thesis, University of Glasgow, Scotland, 1980

    Google Scholar 

  30. Lindsay RM, Prentice CRM, Davidson JF, Burton JA, McNicol GP: Haemostatic changes during dialysis associated with thrombus formation on dialysis membranes. Br Med J 4: 454, 1972

    PubMed  CAS  Google Scholar 

  31. Chang TMS, Chirito E, Barre B, Cole C, Hewish M: Clinical performance-characteristics of a new combined system for simultaneous hemoperfusion-hemodialysis-ultrafiltration in series. Trans Am Soc Artif Intern Organs 21: 502, 1975

    PubMed  CAS  Google Scholar 

  32. Stefoni S, Coli L, Feliciangeli G, Baldrati L, Bonomini V: Regular hemoperfusion in regular dialysis treatment. A long-term study. Int J Artif Organs 3: 348, 1980

    PubMed  CAS  Google Scholar 

  33. Muirhead EE, Reid AF: Resin artificial kidney. J Lab Clin Med 33: 841, 1948

    PubMed  CAS  Google Scholar 

  34. Schreiner GE: The role of hemodialysis (artificial kidney) in acute poisoning. Arch Intern Med 102: 896, 1958

    CAS  Google Scholar 

  35. Rosenbaum JL, Onesti G, Heider C: The removal of cation from dogs with an ion-exchange column. JAMA 180: 762, 1962

    Google Scholar 

  36. Kissack AS, Gliedman L, Karlson KE: Studies with ion exchange resins. Trans Am Soc Artif Intern Organs 8: 219, 1962

    PubMed  Google Scholar 

  37. Nealon TF Jr, Ching N: An extracorporeal device to lower blood ammonia levels in hepatic coma. Trans Am Soc Artif Intern Organs 8: 226, 1962

    PubMed  Google Scholar 

  38. Yatzidis H, Voudiclari S, Oreopoulos D, Tsaparas N, Triantaphyllidis D, Gavras C, Stavroulaki A: Treatment of severe barbiturate poisoning. Lancet 2: 216, 1965

    Google Scholar 

  39. Chang TMS, Gonda A, Dirks JH, Malave N: Clinical evaluation of chronic intermittent and short term hemoperfusion in patients with chronic renal failure using semipermeable microcapsules (artificial cells) formed from membrane coated activated charcoal. Trans Am Soc Artif Intern Organs 17: 246, 1971

    PubMed  CAS  Google Scholar 

  40. Chang TMS, Migchelsen M: Characterization of possible ‘toxic’ metabolites in uremia and hepatic coma based on the clearance spectrum for larger molecules by the ACAC microcapsule artificial kidney. Trans Am Soc Artif Intern Organs 19: 314, 1973

    PubMed  CAS  Google Scholar 

  41. Chang TMS, Migchelsen M, Coffey JF, Stark R: Serum middle molecule levels in uremia during long term intermittent hemoperfusion with ACAD (coated charcoal) microcapsule artificial kidney. Trans Am Soc Artif Intern Organs 20: 364, 1974

    Google Scholar 

  42. Oules R, Asaba H, Neuhauser M, Yahiel V, Gunnarsson B, Bergström J, Fürst P: Removal of uremic small and middle molecules and free amino acids by carbon hemoperfusion. Trans Am Soc Artif Intern Organs 23: 583, 1977

    PubMed  CAS  Google Scholar 

  43. Chang TMS: Assessment of clinical trials of charcoal hemoperfusion in uremic patients. Clin Nephrol 11: 111, 1979

    PubMed  CAS  Google Scholar 

  44. Rosenbaum JL, Kramer MS, Raja R, Henriques M: Hemoperfusion in uremia: Effect of time, solute competition and biocompatibility on column adsorption, in: Hemoperfusion, Kidney and Liver Support and Detoxification edited by Sideman S, Chang TMS, Washington DC, Hemisphere Publishing Corp, 1980,p 245

    Google Scholar 

  45. Gelfand MC, Winchester JF: Hemoperfusion results in uremia. Clin Nephrol 1: 107, 1979

    Google Scholar 

  46. Trznadel K, Walasek L, Kidawa Z, Lutz W: Comparative studies on the effect of hemoperfusion and hemodialysis on the elimination of some uremic toxins. Clin Nephrol 10: 229, 1978

    PubMed  CAS  Google Scholar 

  47. Weber WJ, Morris JC: Kinetics of adsorption on carbon from solutions. Proc Am Soc Civil Eng 89: 31, 1963

    Google Scholar 

  48. Martin AM, Gibbins JK, Kimmitt J, Rennie F: Hemodialysis and hemoperfusion in the treatment of uremic pericarditis. A study of 13 cases. Dial Transplant 8: 135, 1979

    Google Scholar 

  49. Odaka M, Kirasawa H, Kobayashi H, Ohkawa M, Soeda K, Tabata Y, Soma M, Sato H: Clinical and fundamental studies of cellulose coated bead-shaped charcoal haemoperfusion in chronic renal failure, in:Hemoperfusion, Kidney and Liver Support and Detoxification edited by Sideman S, Chang TMS, Washington DC, Hemisphere Publishing Corp, 1980, p 45

    Google Scholar 

  50. Trznadel K, Luciak M, Wyszogrodzka M: Effect of haemoperfusion on the left ventricular systolic function in patients with chronic uraemia. Acta Med Pol 22: 75, 1981

    PubMed  CAS  Google Scholar 

  51. Asaba H: Uremic middle molecules. Accumulation, renal excretion and elimination by extracorporeal treatment. Scand J Urol Nephrol Supplement 67: 1, 1982

    CAS  Google Scholar 

  52. Asaba H, Bergström J, Fürst P, Gunnarsson B, Neuhauser M, Oules R, Yahile V: Removal of endogenous middle molecules by hemoperfusion. Artif Organs 3: 132, 1979

    PubMed  CAS  Google Scholar 

  53. Otsubo O, Kuzuhara K, SimadaY, Yamauchi Y, Takahashi I, Yamada Y, Otsubo K, Inou T: Treatment of uraemic peripheral neuritis by direct haemoperfusion with activated charcoal. Proc Eur Dial Transplant Assoc 16: 731, 1979

    PubMed  CAS  Google Scholar 

  54. Agishi T, Yamashita N, Ota K: Clinical results of direct charcoal hemoperfusion for endogenous and exogenous intoxication. in: Hemoperfusion, Kidney and Liver Support and Detoxification edited by Sideman S, Chang TMS, Washington DC, Hemisphere Publishing Corp, 1980, p 255

    Google Scholar 

  55. Chang TMS, Barre P, Kuruvilla S: Long-term reduced time hemoperfusion-hemodialysis compared to standard dialysis. A preliminary crossover analysis. Trans Am Soc Artif Intern Organs 31: 572, 1985

    PubMed  CAS  Google Scholar 

  56. Henderson IS, Kennedy AC: Long-term evaluation of charcoal haemoperfusion combined with dialysis for uraemic patients. in: Biomaterials in Artificial Organs edited by Paul JP, Gaylor JDS, Courtney JM, Gilchrist T, London, Basingstoke, The Macmillan Press Ltd, 1984, p 72

    Google Scholar 

  57. Siemsen AW, Dunea G, Mamdani BH, Guruprakash G: Charcoal hemoperfusion for chronic renal failure.Nephron 22: 386, 1978

    PubMed  CAS  Google Scholar 

  58. Odaka M, Tabata Y, Kabayashi H, Nomura Y, Soma A, Hirasawa A, Sato H: Clinical experience of bead-shaped charcoal hemoperfusion in chronic renal failure and fulminant hepatic failure, in: Artificial Kidney, Artificial Liver and Artificial Cells edited by Chang TMS, New York, Plenum Press, 1978,p 79

    Google Scholar 

  59. Bonomini V, Stefoni S, Feliciangeli G, Coli L, Scolari MP, Orsi C, Nanni Costa A, Prandini R, Galanti S: Shortened treatment time by combined hemodialysis and hemoperfusion. Contr Nephrol 44: 57, 1985

    CAS  Google Scholar 

  60. Bonomini V, Stefoni S, Feliciangeli G, Coli L, Scolari MP, Prandini R, Casciani CU, Taccone Gallucci, Albertazzi A, Mioli V, Mastrangelo F: Present status of hemoperfusion/hemodialysis in Italy. Appl Biochem Biotechnol 10: 157, 1984

    PubMed  CAS  Google Scholar 

  61. Stefoni S, Coli L, Feliciangeli G, Scolari MP, Bonomini V: Hemoperfusion in reduced-time programmes for chronic uremia. Long term results. Int J Artif Organs 9: 297, 1986

    PubMed  CAS  Google Scholar 

  62. Barre PE, Gonda A, Chang TMS: Routine clinical applications of hemodialysis-hemoperfusion in chronic renal failure: case reports. Int J Artif Organs 9: 305, 1986

    PubMed  CAS  Google Scholar 

  63. Espinosa-Melendez E, Bourgouin PA, Chang TMS: Combined hemoperfusion-hemodialysis in the treatment of uremic patients with vascular access problems: case reports. Int J Artif Organs 9: 309, 1986

    PubMed  CAS  Google Scholar 

  64. Stefoni S, Nanni Costa A, Liviano D’Arcangelo G, Biavati M, Ianelli S, Bonomini V: Biocompatibility of charcoal hemoperfusion. Effects of long-term treatment on lymphocyte characteristics and function. Int J Artif Organs 9: 301, 1986

    PubMed  CAS  Google Scholar 

  65. Capodicasa G, De Santo NG, Galione A, Bellavia C, Annaloro R, Vaccaro F, Picone F, Vinti V, Davi G, Rapisarda LM, Giordano C: CAPD plus hemoperfusion once a week for end stage renal disease. Int J Artif Organs 5: 125, 1981

    Google Scholar 

  66. Capodicasa G, Davi G, Picone F, Mattina A, Gianetto V, Vinti V, Vaccaro F, Strano A, De Santo NG, Giordano C: Platelet thromboxane formation and BTG levels after intensive charcoal hemoperfusion in uremia or regular hemodialysis treatment.Int J Artif Organs 6: 241, 1983

    PubMed  CAS  Google Scholar 

  67. Winchester JF, Ash SR: Hemoperfusion for uremia: Past present and future.Kidney Int 28 (Suppl 17): S127, 1985

    Google Scholar 

  68. Hone PWE, Farrell PC: Urea adsorption capacity of sulfonated polystyrenes. asaio J 3: 1, 1980

    CAS  Google Scholar 

  69. Ash SR, Barile RG, Wilcox PG, Wright DL, Thornhill JA, Dhein CR, Kessler DP, Wang N-HL: The sorbent suspension reciprocating dialyzer: a device with minimal sorbent saturation. asaio J 4: 28, 1981

    Google Scholar 

  70. Chang TMS, Barre P: Effect of desferrioxamine on removal of aluminium and iron by coated charcoal haemoperfusion and haemodialysis. Lancet 2: 1051, 1983

    PubMed  CAS  Google Scholar 

  71. Hakim RM, Schulman JM, Lazarus JM: Hemoperfusion in the treatment of aluminum (Al) and iron (Fe) induced bone disease. Abstracts Am Soc Nephrol 18: 65A, 1985

    Google Scholar 

  72. Winchester JF: Management of iron overload. Semin Nephrol 4 (suppl 1): 22, 1986

    Google Scholar 

  73. Vale JA, Meredith T, Buckley B: ABC of poisoning. Eliminating poisons. Br Med J 289: 366, 1984

    CAS  Google Scholar 

  74. Litovitz T, Veltri J: 1984 Annual report of the American Association of Poison Control Centers. Am J Emerg Med 3: 423, 1985

    PubMed  CAS  Google Scholar 

  75. Henry JA, Cassidy SL: Membrane stabilising ability: A major cause of fatal poisoning. Lancet 1: 1414, 1986

    PubMed  CAS  Google Scholar 

  76. Litovitz TL, Normann SA, Veltri JC: 1985 Annual report of the American Association of Poison Control Centers National Data Collection System. Am J Emerg Med 4: 427, 1986

    PubMed  CAS  Google Scholar 

  77. Haddad LM: A general approach to poisoning, in: Office Procedures: Office Management of Poisoning edited by Winchester JF, Philadelphia, Hanley and Belfus Inc, 1986, p 325

    Google Scholar 

  78. Clemmesen C, Nilsson E: Therapeutic trends in the treatment of barbiturate poisoning: The Scandinavian method. Clin Pharmacol Ther 2: 220, 1961

    PubMed  CAS  Google Scholar 

  79. Lawson AA, Mitchell I: Patients with acute poisoning seen in a general medical unit (1960–1971). Br Med J 4 153, 1972

    PubMed  CAS  Google Scholar 

  80. Reed CE, Driggs MF, Foote CC: Acute barbiturate intoxication: A study of 300 cases based on a physiologic system of classification of the severity of the intoxication. Ann Intern Med 37: 290, 1952

    PubMed  CAS  Google Scholar 

  81. Winchester JF, Gelfand MC, Tilstone WJ: Hemoperfusion in drug intoxication – Clinical and laboratory aspects. Drug Metab Rev 8: 69, 1978

    PubMed  CAS  Google Scholar 

  82. Mäher JF, Schreiner GE: The dialysis of poisons and drugs. Trans Am Soc Artif Intern Organs 13: 369, 1967

    Google Scholar 

  83. Winchester JF, Gelfand MC, Knepshield JH, Schreiner GE: Dialysis and hemoperfusion of poisons and drugs – Update. Trans Am Soc Artif Intern Organs 23: 762, 1977

    PubMed  CAS  Google Scholar 

  84. Cohan SL, Winchester JF, Gelfand MC: Treatment of intoxications by charcoal hemadsorption.Drug Metab Rev 13: 681, 1982

    PubMed  CAS  Google Scholar 

  85. Rosenbaum JL, Kramer MS, Raja RM, Krug MJ, Boliday CG: Current status of hemoperfusion in toxicology.Clin Toxicol 17: 493, 1980

    PubMed  CAS  Google Scholar 

  86. Winchester JF, Tilstone WJ, Edwards RO, Gilchrist T, Kennedy AC: Hemoperfusion for enhanced drug elimination – A kinetic analysis in paracetamol poisoning. Trans Am Soc Artif Intern Organs 20: 358, 1974

    Google Scholar 

  87. Gibson TP, Atkinson AJ: Effect of changes in intercompartmental rate constants on drug removal during hemoperfusion. J Pharm Sci 67: 1178, 1978

    PubMed  CAS  Google Scholar 

  88. Zmuda MJ: Resin hemoperfusion in dogs intoxicated with ethychlorvynol (Placidyl), Kidney Int 17: 303, 1980

    PubMed  CAS  Google Scholar 

  89. Ehlers SM, Zaske DE, Sawchuck RJ: Massive theophylline overdose. Rapid elimination by charcoal hemoperfusion. JAMA 240: 474, 1978

    PubMed  CAS  Google Scholar 

  90. Winchester JF, Rahman A, Tilstone WJ, Kessler A, Mortensen L, Schreiner GE, Schein PS: Sorbent removal of adriamycin in vitro and in vivo. Cancer Treat Rep 63: 1787, 1979

    PubMed  CAS  Google Scholar 

  91. Pond S, Rosenberg J, Benowitz NL, Takki S: Pharmacokinetics of haemoperfusion in drug overdose. Clin Pharmacokinet 4: 329, 1979

    PubMed  CAS  Google Scholar 

  92. Verpooten GA, De Broe ME: Combined hemoperfusion – hemodialysis in severe poisoning: Kinetics of drug extraction. Resuscitation 11: 275, 1984

    PubMed  CAS  Google Scholar 

  93. Cutler RE, Forland SC, St John Hammond PG, Evans RJ: Extracorporeal removal of drugs and poisons by hemodialysis and hemoperfusion.Annu Rev Pharmacol Toxicol 27: 169, 1987

    PubMed  CAS  Google Scholar 

  94. Farrell PC: Commentary: Acute drug intoxication and extracorporeal intervention, asaio J 3: 39, 1980

    Google Scholar 

  95. De Broe ME, Bismuth C, De Groot G, Heath A, Okonek S, Ritz DR, Verpooten GA, Volans GN, Widdop B: Haemoperfusion: a useful therapy for a severly poisoned patient? Hum Toxicol 5: 11, 1986

    PubMed  Google Scholar 

  96. Lorch JA, Garella S: Hemoperfusion to treat intoxications. Ann Intern Med 91: 301, 1979

    PubMed  CAS  Google Scholar 

  97. Maher JF: In discussion in hemoperfusion for poisoning - Is it really necessary? in: Controversies in Nephrology, Volume 2, edited by Schreiner GE, Winchester JF, Washington DC, Georgetown Nephrology Press, 1980, p 228

    Google Scholar 

  98. Hampel G, Crome P, Widdop B, Goulding R: Experience with fixed-bed charcoal haemoperfusion in the treatment of severe drug intoxication. Arch Toxicol 45: 133, 1980

    PubMed  CAS  Google Scholar 

  99. Uldall PR: Controlled trial of resin hemoperfusion for the treatment of drug overdose at Toronto Western Hospital (TWH). Trans Am Soc Artif Intern Organs 28: 676, 1982

    Google Scholar 

  100. De Broe ME, Verpooten BA, Van Haesebrouck B: Recent experience with prolonged hemoperfusion-hemodialysis treatment.Artif Organs 3: 188, 1979

    PubMed  Google Scholar 

  101. Winchester JF: Methanol, isopropyl alcohol, higher alcohols, ethylene glycol, cellosolves, acetone and oxalate, in: Clinical Management of Poisoning and Drug Overdose edited by Haddad LM, Winchester JF, Philadelphia, WB Saunders Co, 1983,p 393

    Google Scholar 

  102. Winchester JF: Active methods for detoxification: Oral sorbents, forced diuresis, hemoperfusion, and hemodialysis, in: Clinical Management of Poisoning and Drug Overdose, edited by Haddad LM, Winchester JF, Philadelphia, WB Saunders Co, 1983, p 154

    Google Scholar 

  103. Proudfoot AT: Salicylates and salicylamides, in:Clinical Management of Poisoning and Drug Overdose, edited by Haddad LM, Winchester JF, Philadelphia, WB Saunders, 1983, p 575

    Google Scholar 

  104. Winters RW, White JS, Hughes MC, Ordway NC: Disturbances of acid-base equilibrium in salicylate intoxication. Pediatrics 23: 260, 1959

    PubMed  CAS  Google Scholar 

  105. Gabow PA, Anderson RJ, Potts DE, Schrier RW: Acid-base disturbances in the salicylate-intoxicated adult. Arch Intern Med 138: 1481, 1978

    PubMed  CAS  Google Scholar 

  106. Anderson RJ, Potts DE, Gabow PA, Rumack BH, Schrier RW: Unrecognized adult salicylate intoxication. Ann Intern Med 85: 745, 1976

    PubMed  CAS  Google Scholar 

  107. Rumack BH, Peterson RG: Acetaminophen overdose: Incidence, diagnosis, and management in 416 patients. Pediatrics 62: 898, 1978

    PubMed  CAS  Google Scholar 

  108. Prescott LF, Illingworth RR, Critchley JA, Stewart MJ, Adam RD, Proudfoot AT: Intravenous N-acetylcysteine. Br Med J 2: 1097, 1979

    PubMed  CAS  Google Scholar 

  109. Gazzard BG, Willson RA, Weston MJ, Thompson R, Williams R: Charcoal haemoperfusion for paracetamol overdose. Br J Clin Pharmacol 1: 217, 1974

    Google Scholar 

  110. Winchester JF, Gelfand MC, Helliwell M, Vale JA, Goulding R, Schreiner GE: Extracorporeal treatment of salicylate oracetaminiphen poisoning – Is there a role? Arch Intern Med 141: 370, 1981

    PubMed  CAS  Google Scholar 

  111. Helliwell M, Vale JA, Goulding R: Hemoperfusion in ‘late’ paracetamol poisoning. Hum Toxicol 1: 25, 1981

    PubMed  CAS  Google Scholar 

  112. Diaz-Buxo JA, Farmer CD, Chandler TY: Hemoperfusion in the treatment of amitriptyline poisoning.Trans Am Soc Artif Intern Organs 24: 699, 1978

    PubMed  CAS  Google Scholar 

  113. Trafford JAP, Jones RH, Evans R, Sharp P, Sharpstone P, Cook J: Haemoperfusion with R-004 amberlite resin for treating acute poisoning. Br Med J 2: 1453, 1977

    PubMed  CAS  Google Scholar 

  114. Trafford A, Sharpstone P, O’Neal H: Haemoperfusion in tricyclic antidepressant poisoning.Lancet 1: 155, 1980

    PubMed  CAS  Google Scholar 

  115. Heath A, Wickstrom I, Ahlmen J: Haemoperfusion in tricyclic antidepressant poisoning.Lancet 1: 155, 1980

    PubMed  CAS  Google Scholar 

  116. Crome P, Braithwaite RA, WiddopB, Medd RK: Haemoperfusion in clinical and experimental tricyclic antidepressant poisoning, in: Hemoperfusion, Kidney and Liver Support and Detoxification edited by Sideman S, Chang TMS, Washington DC, Hemisphere Publishing Corp, 1980, p 301

    Google Scholar 

  117. Pedersen RS: Haemoperfusion in tricyclic antidepressant poisoning.Lancet 1: 154, 1980

    PubMed  CAS  Google Scholar 

  118. Carvallo A, Ramirez B, Honig H, Knepshield J, Schreiner GE, Gelfand MC: Treatment of digitalis intoxication by charcoal hemoperfusion. Trans Am Soc Artif Intern Organs 22: 718, 1976

    PubMed  CAS  Google Scholar 

  119. Gibson TP, Lucas SV, Nelson HA, Atkinson AJ, Okita GT, Ivanovich P: Hemoperfusion removal of digoxin from dogs. J Lab Clin Med 91: 673, 1978

    PubMed  CAS  Google Scholar 

  120. Shah G, Nelson HA, Atkinson AJ, Okita GT, Ivanovich P, Gibson TP: Effect of hemoperfusion on the pharmacokinetics of digitoxin in dogs. J Lab Clin Med 93: 370, 1979

    PubMed  CAS  Google Scholar 

  121. Marbury T, Mahoney J, Juncos L, Conti R, Cade R: Advanced digoxin toxicity in renal failure – Treatment with charcoal hemoperfusion. South Med J 72: 279, 1979

    PubMed  CAS  Google Scholar 

  122. Tobin M, Cerra F,Steinvach J,Mookerjee B: Hemoperfusion in digitalis intoxication: A comparative study of coated versus uncoated charcoal. Trans Am Soc Artif Intern Organs 23: 730, 1977

    PubMed  CAS  Google Scholar 

  123. Hoy WE, Gibson TP, Rivero AJ, Jain JK, Talley TT, Bayer RM, Montondo DF, Freeman RB: XAD-4 resin hemoperfusion for digitoxic patients with renal failure.Kidney Int 23: 79, 1983

    PubMed  CAS  Google Scholar 

  124. Warren SE, Fanestil DF: Digoxin overdose: Limitations of hemoperfusion - hemodialysis treatment. JAMA 242: 2100, 1979

    PubMed  CAS  Google Scholar 

  125. Freed CR, Gerber JG, Cal J, RumakBH, Nies AS: Hemoperfusion in drug overdose. JAMA 241: 1575, 1979

    PubMed  CAS  Google Scholar 

  126. Slattery JR, Koup JR: Hemoperfusion in the management of digoxin toxicity. Is it warranted? Clin Pharmacokinet 4: 395, 1979

    PubMed  CAS  Google Scholar 

  127. Wenger TL, Butler VP Jr, Haber E, Smith TW: Treatment of 63 severely digitalis-toxic patients with digoxin specific antibody fragments. J Am Coll Cardiol 5 ([5] Suppl A): 118A, 1985

    Google Scholar 

  128. Colburn WA: Specific antibodies and Fab fragments to alter the pharmacokinetics and reverse the pharmacologic/toxicologic effects of drugs. Drug Metab Rev 11: 233, 1980

    Google Scholar 

  129. Maini R, Winchester JF: Removal of paraquat from blood by haemoperfusion over sorbent materials. Br Med J 3: 281, 1975

    PubMed  CAS  Google Scholar 

  130. Gelfand MC, Winchester JF, Knepshield JH, Hanson KM, Cohan SL, Strauch BS, Geoly KL, Kennedy AC, Schreiner GE: Treatment of severe drug overdose with charcoal hemoperfusion. Trans Am Soc Artif Intern Organs 23: 599, 1977

    PubMed  CAS  Google Scholar 

  131. Van de Vyver FL, Giuliano RA, Paulus GJ, Verpooten GA, Franke JP, De Zeeuw RA, Van Gaal LF, De Broe ME: Hemoperfusion-hemodialysis ineffective for paraquat removal in life-threatening poisoning? J Toxicol Clin Toxicol 23: 117, 1985

    PubMed  Google Scholar 

  132. Mascie-Taylor BH, Thompson J, Davison AM: Haemoperfusion ineffective for paraquat removal in life-threatening poisoning. Lancet 1: 1376, 1983

    PubMed  CAS  Google Scholar 

  133. Okonek S, Baldamus CA, Hofman A, Schuster CJ, Bechstein PB, Zoller B: Two survivors of severe paraquat intoxication by ‘continuous hemoperfusion.’ Klin Wochenschr 57: 957, 1979

    PubMed  CAS  Google Scholar 

  134. Sahney S, Abarzua J, Sessums L: Hemoperfusion in theophylline neurotoxicity. Pediatrics 71: 615, 1983

    PubMed  CAS  Google Scholar 

  135. Park GD, Spector R, Roberts RJ, Goldberg MJ, Weissman D, Stillerman A, Flanigan MJ: Use of hemoperfusion for treatment of theophylline intoxication. Am J Med 74: 961, 1983

    PubMed  CAS  Google Scholar 

  136. Connell JM, McGeachie JF, Knepil J, Thomson A, Junor B: Self-poisoning with sustained-release aminophylline: secondary rise in serum theophylline concentration after charcoal haemoperfusion.Br Med J 284: 943, 1982

    CAS  Google Scholar 

  137. Woo OF, Pond S, Benowitz NL, Olson KR: Benefit of hemoperfusion in acute theophylline intoxication. J Toxicol Clin Toxicol 22: 411, 1984

    PubMed  CAS  Google Scholar 

  138. Ahlmen J, Heath A, Herlitz H, Kvist L, Mellstrand T: Treatment of oral theophylline poisoning. Acta Med Scand 216: 423, 1984

    PubMed  CAS  Google Scholar 

  139. Schwartz RD: Deferoxamine and aluminum removal. Am J Kidney Dis 6: 358, 1985

    Google Scholar 

  140. Brown DJ, Dawborn JK, Ham KN, Xipell JM: Treatment of dialysis osteomalacia with desferrioxamine. Lancet 2: 343, 1982

    PubMed  CAS  Google Scholar 

  141. Andress DL, Maloney NA, Endres DB, Sherrard DJ: Aluminum-associated bone disease in chronic renal failure: high prevalence in a long-term dialysis population. J Bone Miner Res 1: 391, 1986

    PubMed  CAS  Google Scholar 

  142. Arieff AI: Aluminum and the pathogenesis of dialysis encephalopathy. Am J Kidney Dis 6: 317, 1985

    PubMed  CAS  Google Scholar 

  143. Bregman H, Gelfand MC, Winchester JF, Manz HJ, Knepshield JH, Schreiner GE: Iron overload-associated myopathy in patients on maintenance haemodialysis. A histocompatibility linked disorder. Lancet 2: 882, 1980

    PubMed  CAS  Google Scholar 

  144. Falk RJ, Mattern WD, Lamanna RW, Gitelman HJ, Parker NC, Cross RE, Rastall JR: Iron removal during continuous ambulatory peritoneal dialysis using deferoxamine. Kidney Int 24: 110, 1983

    PubMed  CAS  Google Scholar 

  145. McCarthy JT, Libertin Cr, Mitchell JC III, Fairbanks VF: Hemosiderosis in a dialysis patient. Treatment with hemofiltration and deferoxamine chelation therapy. Mayo Clin Proc 57: 439, 1982

    PubMed  CAS  Google Scholar 

  146. Marcus RE, Davies SC, Bantock HM, Underwood SR, Walton S, Huehns ER: Desferrioxamine to improve cardiac function in iron overloaded patients with thalassemia major. Lancet 1: 392, 1984

    PubMed  CAS  Google Scholar 

  147. Wolfe L, Olivieri N, Sallan D, Colan S, Rose V, Propper R, Freedman M, Nathan DG: Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major. N Engl J Med 312: 1600, 1985

    PubMed  CAS  Google Scholar 

  148. Worth DP, Davison AM, Lewins AM, Ledgerwood MJ, Taylor A: Haemodialysis and charcoal haemoperfusion in acute inorganic mercury poisoning. Postgrad Med J 60: 636, 1984

    PubMed  CAS  Google Scholar 

  149. De Backer W, Zachee P, Verpooten GA, Majelyne W, Vanheule A, De Broe ME: Thallium intoxication treated with combined hemoperfusion-hemodialysis. J Toxicol Clin Toxicol 19: 259, 1982

    PubMed  Google Scholar 

  150. De Groot G, van Heijst AN, van Kesteren RG, Maes RA: An evaluation of the efficacy of charcoal haemoperfusion in the treatment of three cases of acute thallium poisoning. Arch Toxicol 57: 61, 1985

    PubMed  Google Scholar 

  151. Lund ME, Banner W, Clarkson TW, Berlin M: Treatment of acute methylmercury ingestion by hemodialysis with n-acetylcysteine (Mucomyst) infusion and 2, 3-dimercaptopropane sulfonate. J Toxicol Clin Toxicol 22: 31, 1984

    PubMed  CAS  Google Scholar 

  152. Al-Abassi AH, Kostyniak PJ, Clarkson TW: An extracorporeal complexing hemodialysis system for the treatment of methylmercury poisoning. Ill Clinical applications. J Pharmacol Exp Ther 207: 249, 1978

    Google Scholar 

  153. Margel S: A novel approach for heavy metal poisoning treatment, a model. Mercury poisoning by means of chelating microspheres; hemoperfusion and oral administration.J Med Chem 24: 1263, 1981

    PubMed  CAS  Google Scholar 

  154. Banner W, Koch M, Capin DM, Hopf SB, Chang S, Tong TG: Experimental chelation therapy in chromium, lead and boron intoxication with n-acetylcysteine and other compounds.Toxicol Appl Pharmacol 83: 142, 1986

    PubMed  CAS  Google Scholar 

  155. Zieve L, Doizeki WM, Zieve FJ: Synergism between mercaptans and ammonia or fatty acids in the production of coma; a possible role for mercaptans in the pathogenesis of hepatic coma. Lab Clin Med 83: 16, 1974

    CAS  Google Scholar 

  156. James TH, Ziparo V, Jeppsson B, Fischer JE: Hyperammonaemia, plasma aminoacid imbalance, and blood-brain aminoacid transport: A unified theory of portal-systemic encephalopathy. Lancet 2: 772, 1979

    PubMed  CAS  Google Scholar 

  157. Schafer DF, Jones EA: Hepatic encephalopathy and the gamma-aminobutyric-acid neurotransmitter system. Lancet 1: 18, 1982

    PubMed  CAS  Google Scholar 

  158. Chang TMS: Haemoperfusion over microencapsulated adsorbent in a patient with hepatic coma. Lancet 2: 1371, 1972

    PubMed  CAS  Google Scholar 

  159. Chang TMS: Hemoperfusion alone and in series with ultrafiltration or dialysis for uremia, poisoning and liver failure. Kidney Int 10 (Suppl 7): S305, 1976

    Google Scholar 

  160. Blume U, Helmstaedt D, Sybrecht G, Baldamus C, Sussmann P, Heyer U, Schmidt E, Schmidt FW: Hamoperfusions-therapie des acuten Leverversagens. (Hemoperfusion treatment for acute hepatic failure) Dtsch Med Wochenschr 101: 559, 1976

    PubMed  CAS  Google Scholar 

  161. Colon AR, Gelfand MC, Winchester JF: Hemocarboperfusion (HCP) in hepatic decompensation and cerebral edema, in: Reye’s Syndrome II edited by Crocker JFS, New York, San Francisco, London, Grune and Stratton, 1978, p 139

    Google Scholar 

  162. Bartels O, Neidhardt B, Neidhardt M, Schellberger H, Issel W, Waldherr AM, Demling L: Untersuchungen und Entahrungen mit der Kohlehaemoperfusion bei Leber-koma. in: Entgiftung mit Hamoperfusion (Investigation and experience with carbon hemoperfusion for liver coma, in: Detoxification by Hemoperfusion) edited by Demling L, Bartels O, Freiburg, Bundernagel-Verlag, 1977, p 119

    Google Scholar 

  163. Gazzard BG, Portmann BA, Weston MJ, Langley PG, Murray-Lyon IM, Dunlop EH, Flax H, Mellon PJ, Record CO, Ward MB, Williams R: Charcoal haemoperfusion in the treatment of fulminant hepatic failure. Lancet 1: 1301, 1974

    PubMed  CAS  Google Scholar 

  164. Silk DBA, Williams R: Sorbents in hepatic failure, in: Sorbents and Their Clinical Applications edited by Giordano C, New York, Academic Press Inc, 1980, p 415

    Google Scholar 

  165. Silk DBA, Williams R: Experiences in the treatment of fulminant hepatic failure by conservative therapy, charcoal haemoperfusion and polyacrylonitrile haemodialysis.Int J Artif Organs 1: 29, 1978

    PubMed  CAS  Google Scholar 

  166. Opolon P, Rapin JR, Huguet C, Granger A, Delorme ML, Boschat M, Sausee A: Hepatic failure coma treated by polyacrylonitrile membrane hemodialysis. Trans Am Soc Artif Intern Organs 22: 701, 1976

    PubMed  CAS  Google Scholar 

  167. Silk DBA, Trewby PN, Chase RA, Mellon PJ, Hanid MA, Davies M, Langley PG, Wheeler PG, Williams R: Treatment of fulminant hepatic failure by polyacrylonitrile membrane haemodialysis. Lancet 2: 1, 1977

    PubMed  CAS  Google Scholar 

  168. Chang TMS, Lister C, Chirito E, O’Keefe P, Resurreccion E: Effects of hemoperfusion rate and time of initiation of ACAC charcoal hemoperfusion on the survival of fulminant hepatic failure rats. Trans Am Soc Artif Intern Organs 24: 243, 1978

    PubMed  CAS  Google Scholar 

  169. Takahashi Y: Acute hepatic failure - in special relation to treatment. Jpn Med J 22: 140, 1983

    CAS  Google Scholar 

  170. Tygstrup N, Ranek L: Fulminant hepatic failure. Clin Gastroenterol 10: 191, 1986

    Google Scholar 

  171. Berk PD: A computer simulation study relating to the treatment of fulminant hepatic failure by hemoperfusion. Proc Soc Exp Biol Med 155: 535, 1977

    PubMed  CAS  Google Scholar 

  172. Hughes RD, Cochrane AMD, Thomson AD, Murray-Lyon, Williams R: Cytotoxicity of plasma from patients with acute hepatic failure to isolated rabbit hepatocytes. Br J Exp Pathol 57: 348, 1976

    PubMed  CAS  Google Scholar 

  173. Gelfand MC, Winchester JF, Knepshield JH, Cohan SL, Schreiner GE: Reversal of hepatic coma by coated charcoal hemoperfusion: Clinical and biochemical observations, asaio J 1: 73, 1978

    Google Scholar 

  174. Amano I, Kano H, Takahira H, Yamamoto Y, Itoh K, Iwatsuki S, Maeda K, Ohta K: Hepatic assist system using bead type charcoal, in: Artificial Kidney, Artificial Liver and Artificial Cells edited by Chang TMS, New York, Plenum Press, 1978,p 89

    Google Scholar 

  175. Seda HWM, Hughes RD, Give CD, Williams R: Removal of inhibitors of brain Na+ K+ ATPase by haemoperfusion in fulminant hepatic failure.Artif Organs 8: 174, 1984

    PubMed  CAS  Google Scholar 

  176. Foster D, Ahmed K, Zieve L: Action of methanethiol on membrane Na+ K+ ATPase: Implications for hepatic coma. Ann NY Acad Sci 242, 573, 1974

    PubMed  CAS  Google Scholar 

  177. Seda HWM, Hughes RD, Give CD, Williams R: Inhibition of rat brain Na+ K+ ATPase activity by serum from patients with fulminant hepatic failure. Hepatology 4: 74, 1984

    PubMed  CAS  Google Scholar 

  178. Langley PG, Hughes RD, Ton HY, Silk DBA, Williams R: The effect of prostaglandin E1 and adenosine on adverse platelet reactions during charcoal haemoperfusion. Thromb Res 13: 351, 1978

    PubMed  CAS  Google Scholar 

  179. Rubin MH, Weston MJ, Bullock G, Roberts J, Langley PG, White YS, Williams R: Abnormal platelet function and ultrastructure in fulminant hepatic failure. Q J Med 46: 339, 1977

    PubMed  CAS  Google Scholar 

  180. Sette H, Hughes RD, Langley PG, Gimson AE, Williams R: Heparin response and clearance in acute and chronic liver disease, thromb Haemostas 54: 591, 1985

    CAS  Google Scholar 

  181. Cordopatri F, Boncinelli S, Marsili M, Lorenzi P, Fabbri LP, Paci P, Salvadori M, Morfini M, Cinoti S, Casparini P: Effects of charcoal haemoperfusion with prostacyclin on the coagulation-fibrinolysis system and platelets of patients with fulminant hepatic failure - preliminary observation. Int J Artif Organs 5: 243, 1982

    PubMed  CAS  Google Scholar 

  182. Kennedy HJ, Greaves M, Triger DR: Clinical experience with the use of charcoal haemoperfusion: Is prostacyclin required? Life Support syst 3: 115, 1985

    PubMed  CAS  Google Scholar 

  183. Ton HY, Hughes RD, Silk DBA, Williams R: Adsorption of human serum albumin to Amberlite XAD-7 resin. J Biomed Mater Res 13: 403, 1979

    Google Scholar 

  184. Hughes RD, Ton HY, Langley PG, Davis M, Hanid MA

    Google Scholar 

  185. Hughes R, Williams R: Clinical experience with charcoal and resin hemoperfusion. Semin Liver Dis 6: 164, 1986

    PubMed  CAS  Google Scholar 

  186. Wagemaker H, Cade R: The use of hemodialysis in chronic schizophrenia. Am J Psychiatr 134: 684, 1977

    PubMed  Google Scholar 

  187. Cade R, Wagemaker H: The use of hemodialysis in chronic schizophrenia. Abstracts Am Soc Artif Intern Organs7: 1, 1978

    Google Scholar 

  188. Kolff WJ: Dialysis of schizophrenics. Weird and novel applications of dialysis, hemofiltration, hemoperfusion, and peritoneal dialysis: Witchcraft? Artif Organs 2: 277, 1978

    PubMed  CAS  Google Scholar 

  189. Gurland HJ: Chronic schizophrenia, in: The S. Neaman Workshop on Hemoperfusion: Devices and Clinical Applications edited by Sideman S, Chang TMS, Haifa, Publication No. 01/108/80, Technion-Israel Institute of Technology, 1980, p 123

    Google Scholar 

  190. Chang TMS: Hemoperfusion in chronic schizophrenia. Int J Artif Organs 1: 253, 1978

    PubMed  CAS  Google Scholar 

  191. Kinney MJ: Hemoperfusion for chronic schizophrenia: Preliminary psychiatric results (Cited in Gurland [191])

    Google Scholar 

  192. Nedipil N, Dieterle D, Gurland HJ: Blood purification treatment of schizophrenia. Int J Artif Organs 3: 76, 1980

    Google Scholar 

  193. Schulz SC, VanKammen DP, Balow JE, Flye NW, Bunney WE: Dialysis in schizophrenia: A double blind evaluation. Science 211: 1066, 1981

    PubMed  CAS  Google Scholar 

  194. Twardowski AJ, Nolph KD, Rubin J, Anderson PC: Peritoneal dialysis for psoriasis. Ann Intern Med 88: 349, 1978

    PubMed  CAS  Google Scholar 

  195. McEvoy J, Kelly AMT: Psoriatic clearance during hemodialysis. Ulster Med J 76: 1976

    Google Scholar 

  196. Breathnach SM, Boon NA, Black MM, Jones NF, Wing AJ: Psoriasis developing during dialysis. Br Med J 1: 236, 1979

    PubMed  CAS  Google Scholar 

  197. Nissensson AB, Rapaport M, Gordon A, Narins RG: Controlled study demonstrates that psoriasis is not improved by hemodialysis. Kidney Int 14: 682, 1978

    Google Scholar 

  198. Maeda K, Asada H, Yamamoto Y, Ohta K: Psoriasis treatment with direct hemoperfusion. in: Hemoperfusion, Kidney and Liver Support and Detoxification edited by Sideman S, Chang TMS, Washington DC, Hemisphere Publishing Corp, 1980,p 349

    Google Scholar 

  199. Tagami H, Ofuji S: Leukotactic properties of soluble substances in psoriasis scale. Br J Dermatol 95: 1, 1978

    Google Scholar 

  200. Winchester JF, Rahman A, Bregman H, Mortensen LM, Gelfand MC, Schein PS, Schreiner GE: Role of hemoperfusion in anticancer drug removal, in: Hemoperfusion, Kidney and Liver Support and Detoxification edited by Sideman S, Chang TMS, Washington DC, Hemisphere Publishing Corp, 1980,p 369

    Google Scholar 

  201. Hande KR, Balow JE, Draje JC, Rosenberg SA, Chabner BA: Methotrexate and hemodialysis. Ann Intern Med 87: 496, 1977

    Google Scholar 

  202. Molina R, Fabian C, Cowley B Jr: Use of charcoal hemoperfusion to reduce serum methotrexate levels in a patient with acute renal insufficiency. Am J Med 82: 350, 1987

    PubMed  CAS  Google Scholar 

  203. Oldfield EH, Dedrick RL, Yeager RL. Clark WC, DeVroom

    Google Scholar 

  204. Terman DS, Garcia-Rinaldi R, McCalman R, Crumb CC, Mattioli C, Cook G, Poser R: Modification of hyperacute renal xenograft rejection after extracorporeal immunoadsorption of heterospecific antibody. Int J Artif Organs 2: 35, 1979

    PubMed  CAS  Google Scholar 

  205. Terman DS, Yamamoto T, Mattioli M, Cook G, Tillquis R, Henry J, Poser Daskal Y: Extensive necrosis of spontaneous canine mammary adenocarcinoma after extracorporeal perfusion over Staphylococcus aureus Cowans I. J Immunol 124: 795, 1980

    PubMed  CAS  Google Scholar 

  206. Terman DS, Betram HJ: Antitumor effects of immobilized protein A and Staphylococcal products: Linkage between toxicity and efficacy and tumoricidal reagents. Eur J Cancer Clin Oncol 21: 1115, 1985

    PubMed  CAS  Google Scholar 

  207. Langone JJ, Das C, Bennett D, Terman DS: Generation of human C3a, C4a, and C5a anaphylotoxin by protein A of Staphylococcus aureus and immobilized protein A reagents in serotherapy of cancer. J Immunol 133: 1057, 1984

    PubMed  CAS  Google Scholar 

  208. Marcus L, Margel S, Savin H, Ofarim M, Ravid M: Therapy of digoxin intoxication in dogs by specific hemoperfusion through agarose polyacrolein microsphere beads-antidigoxin antibodies. Am Heart J110: 30, 1985

    PubMed  CAS  Google Scholar 

  209. Savin H, Marcus L, Margel S, Ofarim M, Ravid M: Treatment of adverse digitalis effects by hemoperfusion through columns with antidigoxin antibodies bound to agarose polyacrolein microsphere beads. Am Heart J113: 1078, 1987

    PubMed  CAS  Google Scholar 

  210. Sideman S, Mor L, Rousseau I, Brandes JM: Ben-Arie D: Removal of bilirubin from the blood of jaundiced infants, in: Artificial Organs edited by Kenedi RM, Courtney JM, Gaylor JDS, Gilchrist T, London, Basingstoke, Macmillan, 1971, p 413

    Google Scholar 

  211. Ocfaka M, Kobayashi H, Tabata Y, Soeda K, Hayashi H, Ito S, Murotani N, Saito Y, Nishide Y, Shinomiya M, Yoshida S: Long term results of LDL selective plasma adsorption therapy on familial hypercholesterolemia. Biomater Artif Cells Artif Organs 15: 113, 1987

    Google Scholar 

  212. Chang TMS, Nicolaev VG: Hemoperfusion, sorbents and immobilized bioreactants. Biomater Artif Cells Artif Organs 15 (special issue), 1987

    Google Scholar 

  213. Yatzidis H, Oreopoulos D: Early clinical trials with sorbents. Kidney Int 10 (Suppl 7): S215, 1976

    Google Scholar 

  214. Yatzidis H, Yullis G, Digenis P: Hemocarboperfusion-haemodialysis treatment in terminal renal failure. Kidney Int 10 (Suppl 7): S312, 1976

    Google Scholar 

  215. Dunea G, Rizvii ZH, Mamdani BH, Anicama HJ, Mahurkar SK: Charcoal hemoperfusion and combination dialysis-hemoperfusion in chronic renal failure. Abstracts Am Soc Artif Intern Organs 5: 22, 1975

    Google Scholar 

  216. Leber HE, Neuhauser M, Goubeaud G: Chronic uraemia: haemodialysis or haemoperfusion? in: Artificial Organs edited by Kenedi RM, Courtney JM, Gaylor JDS, Gilchrist T, London, Basingstoke, Macmillan Press Ltd, 1977, p 220

    Google Scholar 

  217. Martin AM, Gibbins JK, Oduro M, Herbert R: Clinical experience with cellulose coated carbon hemoperfusion. in:Artificial Liver, Artificial Kidney, and Artificial Cells edited by Chang TMS, Plenum Press, New York, 1978, p 143

    Google Scholar 

  218. Mydlik M, Bucek J, Derzsiova K, Jarcuska J, Takac M: Influence of charcoal haemoperfusion on platelet count in acute poisoning and during regular dialysis treatment. Int Urol Nephrol 13: 387, 1981

    PubMed  CAS  Google Scholar 

  219. Splendiani G, Albano V, Trancredi M, Daniele M, Pignatelli F: Our experience with combined hemodialysis-hemoperfusion treatment in chronic uremia. Biomater Artif Cells Artif Organs 15: 175, 1987

    PubMed  CAS  Google Scholar 

  220. Yamazaki Z, Fujimori Y, Sanjo K, Kojima Y, Sugiura M, Wada T, Inoue N, Sakai T, Oda T, Kominami N, Fujisake U, Kataoka K: New artificial liver support system (Plasma perfusion detoxification) for hepatic coma. Artif Organs 1: 148, 1977

    Google Scholar 

  221. Bartels O, Neidhardt M, Schellberger H: Hormone losses by charcoal haemoperfusion. in: Artificial Liver Support edited by Brunner G, Schmidt FW, Berlin, Springer-Verlag, 1981, p 121

    Google Scholar 

  222. Williams R: Fulminant hepatic failure. Postgrad Med J 59 (Suppl 4): 33, 1983

    PubMed  Google Scholar 

Download references

Authors
  1. James F. Winchester
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Nephrology Division, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    John F. Maher M.D., FACP (Professor of Medicine, Director) (Professor of Medicine, Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers

About this chapter

Cite this chapter

Winchester, J.F. (1989). Hemoperfusion. In: Maher, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1087-4_20

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-1087-4_20

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6979-3

  • Online ISBN: 978-94-009-1087-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation