Short Treatment

  • James H. Shinaberger
  • Joseph H. Miller
  • Peter W. Gardner

Abstract

An examination of the possibility of shortening the time required for dialytic treatment is justified on the basis that patients desire it, and always have. If a time consuming, absolutely necessary treatment can be safely and comfortably applied to meet all currently understood requirements for adequacy in a substantially shorter time than the standard treatment, the potential beneficial effect on the patients’ quality of life is beyond debate. As discussed herein, standard therapy is of 4 to 6 h duration. Short treatment strategies should provide equivalent net volume and solute removal in 3 h or less. The intent of this chapter is to create a durable summation of those principles, limitations and constraints which must be understood to create adequate, safe and tolerable shortened treatment strategies. Current strategies and technologies are evolving rapidly and will be presented relatively briefly. Only references to material of basic importance are cited, rather than an encyclopedic review.

Keywords

Blood Pump Dialysate Flow Urea Clearance Dialyzer Clearance Conventional Hemodialysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Wolf AV, Remp DG, Kiley JE, Currie GD: Artificial kidney function: kinetics of hemodialysis. J Clin Invest 30: 1062, 1951PubMedCrossRefGoogle Scholar
  2. 2.
    Alwall N, Norviit L, Steins AM: On the artificial kidney, VII, Clinical experiences of dialysis treatment of uremia. Acta Med Scand 132: 587, 1948CrossRefGoogle Scholar
  3. 3.
    Muehrcke RC: Acute Renal Failure, St. Louis, The CV Mosby CO 1969, p 277Google Scholar
  4. 4.
    Maher JF, Schreiner GE, Waters TJ: Successful intermittent hemodialysis-longest reported maintenance of life in true oliguria (181 days). Trans Am Soc Artif Intern Organs 6: 123, 1960PubMedGoogle Scholar
  5. 5.
    Hegstrom RM, Murray JS, Pendras GP, Burnell JM, Scribner BH: Hemodialysis in the treatment of chronic uremia. Trans Am Soc Artif Intern Organs 7: 136, 1961PubMedGoogle Scholar
  6. 6.
    Cole JJ, Quinton WE, Williams C, Murray JS, Sherris JC: The pumpless low temperature hemodialysis system. Trans Am Soc Artif Intern Organs 8: 209, 1962PubMedGoogle Scholar
  7. 7.
    Alwall N: A new disposable artificial kidney – experimental and clinical experience. Proc Eur Dial Transplant Assoc 5:18, 1968Google Scholar
  8. 8.
    Stewart RD, Lipps BJ, Borella ED, Puring WR, Roth DA, Sargent JA: Short-term hemodialysis with the capillary kidney. Trans Am Soc Artif Intern Organs 14: 121, 1968PubMedGoogle Scholar
  9. 9.
    Gotch F, Lipps BJ, Weaver J Jr, Brandes J, Rosin J, Sargent JA, Oja P: Chronic dialysis with the hollow fiber artificial kidney (HFAC). Trans Am Soc Artif Intern Organs 15: 87, 1969PubMedGoogle Scholar
  10. 10.
    Shaldon S, Florence P, Fontanuo P, Palito C, Mion C: Comparison of two strategies for short dialysis using 1 M2 and 2 M2 surface area dialyzers. Proc Eur Dial Transplant Assoc 12: 596, 1974Google Scholar
  11. 11.
    Keshaviah P, Berkseth R, Ilstrup K, McMichael C, Collins A: Reduced treatment time: hemodialysis (HD) versus hemofiltration (HF). Trans Am Soc Artif Intern Organs 31: 176, 1985PubMedGoogle Scholar
  12. 12.
    Mirahmadi KS, Kay JH, Miller JH, Gorman JJ, Rosen SM: Clinical evaluation of patients dialyzed with double Gambro four hours, three times per week. Proc Eur Dial Transplant Assoc 11: 121, 1974Google Scholar
  13. 13.
    Cambi V, Garini G, Sovazzi, Arisi L, David S, Zanelli P, Bono F, Gardini F: Short dialysis. Proc Eur Dial Transplant Assoc 20: 111, 1983PubMedGoogle Scholar
  14. 14.
    Bosl R, Shideman JR, Meyer RM, Buselmeier TJ, von Hartitzsch B, Kjellstrand CM: Effects and complications of high efficiency dialysis. Nephron 15: 151, 1975PubMedCrossRefGoogle Scholar
  15. 15.
    ManjiT, Maeda K, Kawaguchi S, Kobayashi K, Ohta K, Saito A, Amano I, Shimoi T, Fujisaki Y: Short time dialysis with 2 M2 hollow fiber kidney. Proc Eur Dial Transplant Assoc 11: 153, 1974Google Scholar
  16. 16.
    Babb AL, Strand MJ, Uvelli DA, Scribner BH: Quantitative description of dialysis treatment: a dialysis index. Kidney Int 2(Suppl2): S23, 1975Google Scholar
  17. 17.
    Ginn HE, Buzel HJ, James L, Hopkins P: Clinical experience with small surface area dialyzers (SSAD). Proc Clin Dial Transplant Forum 1: 53, 1971PubMedGoogle Scholar
  18. 18.
    Milutinovich J, Halar EM, Hacker LA, Babb AL, Scribner BH: Further experience with hemodialysis at 100 ml/min dialysate flow. Proc Clin Dial Transplant Forum 1: 48, 1971Google Scholar
  19. 19.
    Bergstrom J, Fürst P: Uremic middle molecules. Clin Nephrol 5: 143, 1976PubMedGoogle Scholar
  20. 20.
    Nolph KD: Short dialysis, middle molecules, and uremia. Ann Intern Med 86: 99, 1977Google Scholar
  21. 21.
    Wauters JP, Pansiot BC, Gilliard N, Stauffer JC: Short hemodialysis: long-term mortality and morbidity. Artif Organs 10: 182, 1986PubMedCrossRefGoogle Scholar
  22. 22.
    Tolchin N: Acetate metabolism and high efficiency hemodialysis. Int J Artif Organs 2: 1, 1979PubMedGoogle Scholar
  23. 23.
    Diamond SM, Henrich WL: Acetate dialysate versus bicarbonate dialysate: a continuing controversy. Am J Kidney Dis 9: 3, 1987PubMedGoogle Scholar
  24. 24.
    Tolchin N, Roberts JL, Hayashi J, Lewis EJ: Metabolic consequences of high mass-transfer hemodialysis. Kidney Int 11: 366, 1977PubMedCrossRefGoogle Scholar
  25. 25.
    Graeffe I, Milutinovich J, Follette WC, Vizzo JE, Babb AL: Less dialysis-induced morbidity and vascular instability with bicarbonate dialysate. Ann Intern Med 88: 332, 1978Google Scholar
  26. 26.
    Shaldon S, Beau MC, Deschodt G, Mion C: Mixed hemofiltration (MHF): 18 months experience with ultrashort treatment time. Trans Am Soc Artif Intern Organs 27: 610, 1981PubMedGoogle Scholar
  27. 27.
    Baldamus C, Ernst W, Frei U, Koch K: Sympathetic and hemodynamic response to volume removal during different forms of renal replacement therapy. Nephron 31: 324, 1982PubMedCrossRefGoogle Scholar
  28. 28.
    Bergström J, Asaba H, Fürst P, Oules R: Dialysis ultrafiltration and blood pressure. Proc Eur Dial Transplant Assoc 13: 293, 1976Google Scholar
  29. 29.
    Asaba H, Bergström J, Fürst P, Lindh K, Mion C, Oules R, Shaldon S: Sequential ultrafiltration and diffusion as alternative to conventional hemodialysis. Proc Clin Dial Transplant Forum 6: 129, 1976PubMedGoogle Scholar
  30. 30.
    Rouby J, Rottemberg J, Durande JP, Basset JY, Degoulet P, Glasser P, Legrain M: Hemodynamic changes induced by regular hemodialysis and sequential ultrafiltration hemodialysis: a comparative study. Kidney Int 17: 801, 1980PubMedCrossRefGoogle Scholar
  31. 31.
    Gotch FA, Sargent JA, Keen ML, Lee M: Individualized, quantified dialysis therapy of uremia. Proc Clin Dial Transplant Forum 4: 27, 1974PubMedGoogle Scholar
  32. 32.
    Gotch FA, Sargent JA, Keen M, Lam M, Prowitt M, Grady M: Clinical results of intermittent dialysis therapy (IDT) guided by ongoing kinetic analysis of urea metabolism. Trans Am Soc Artif Intern Organs 22: 175, 1976PubMedGoogle Scholar
  33. 33.
    Lowrie EG, Laird NM: (editors) The National Cooperative Dialysis Study. Kidney Int 23(Suppl 13): S1, 1983Google Scholar
  34. 34.
    Gotch FA, Sargent JH: A mechanistic analysis of the National Cooperative Dialysis Study (NCDS). Kidney Int 28: 526, 1985PubMedCrossRefGoogle Scholar
  35. 35.
    Teschan PE, Ginn HE, Bourne JR, Ward JW, Schaffer JD: A prospective study of reduced dialysis, asaio J 6: 108, 1983Google Scholar
  36. 36.
    Gotch FA: Urea kinetic modeling to guide hemodialysis therapy in adults in Dialysis Therapy, edited by Nissenson AR, Fine RN, Philadelphia, Hanley & Belfus, Inc, 1986, p 66Google Scholar
  37. 37.
    Farrell PC: Kinetic modeling in hemodialysis in Clinical Dialysis. edited by Nissenson AR, Fine RN, Gentile DE, Norwalk, Appleton-Century-Crofts, 1984, p 141Google Scholar
  38. 38.
    Norvit EG, Teschan PE: Principles of prescribing dialysis therapy: implementing recommendations from the National Cooperative Dialysis Study. Kidney Int 23(Suppl 13): S 113, 1983Google Scholar
  39. 39.
    Ilstrup K, Hanson G, Shapiro W, Keshaviah P: Examining the foundations of urea kinetics. Trans Am Soc Artif Intern Organs 3 1: 164, 1985Google Scholar
  40. 40.
    Keshaviah P, Ilstrup K, Shapiro W, Hanson G: Hemodialysis urea kinetics is not single pool. Abstracts Am Soc Nephrol 17: 67A, 1984Google Scholar
  41. 41.
    Schindhelm K, Skalsky M, Mahony JF, Farrell PC: Creatinine transfer between interstitial and intracellular fluid: a comparison between normal and uremic subjects, asaio J 2: 35, 1979Google Scholar
  42. 42.
    Schindhelm K, Farrell PC: Patient – hemodialyzer interactions. Trans Am Soc Artif Intern Organs 24: 357, 1978PubMedGoogle Scholar
  43. 43.
    Miller JH, Gardner PW, Shinaberger JH, von Albertini B: Modeling short treatment: a practical mathematical approach. Blood Purif 2: 214, 1984Google Scholar
  44. 44.
    Jindal KK, Manuel A, Goldstein MB: Percent reduction of the blood urea concentration during hemodialysis (PRU), a simple and accurate method to estimate Kt/V urea. Abstracts Am Soc Artif Intern Organs 16: 49, 1987Google Scholar
  45. 45.
    Colton CK, Smith DKA, Merrill EW, Reece JM: Diffusion of organic solutes in stagnant plasma and red cell suspensions. Chem Eng Prog Symp Ser No 99 66: 85, 1970Google Scholar
  46. 46.
    Babb AL, Popovich RP, Farrell PC, Blagg CR: The effects of erythrocyte mass transfer rates on solute clearance measurements during hemodialysis. Proc Eur Dial Transplant Assoc 9: 303, 1972PubMedGoogle Scholar
  47. 47.
    Michaels AS: Operating parameters and performance criteria for hemodialyzers and other membrane – separation devices. Trans Am Soc Artif Intern Organs 12: 387, 1966PubMedGoogle Scholar
  48. 48.
    Gotch FA, Autian J, Colton CK, Ginn HE, Lipps BJ, Lowrie E: The evaluation of hemodialyzers. DHEW publication No. (NIH) 72:103,1972Google Scholar
  49. 49.
    Miller JH, Shinaberger JH, Gardner PW: Extended mathematical analysis of dialyzer function. Opuscula Medico-technica Lundensia X17,1974Google Scholar
  50. 50.
    von Albertini B, Miller JH, Gardner PW, Shinaberger JH: High-flux hemodiafiltration: under six hours/week treatment. Trans Am Soc Artif Intern Organs 30: 227, 1984Google Scholar
  51. 51.
    Miller JH, von Albertini B, Gardner PW, Shinaberger JH: Technical aspects of high-flux hemodiafiltration for adequate short (under 2 hours) treatment. Trans Am Soc Artif Intern Organs 30: 377, 1984PubMedGoogle Scholar
  52. 52.
    Quellhorst E, Scheunemann B, Hildebrand U: How to prevent vascular instability: haemofiltration. Proc Eur Dial Transplant Assoc 18: 243, 1981PubMedGoogle Scholar
  53. 53.
    Schilling H, Lehman H, Hampl H: Studies on circulatory stability during bicarbonate hemodialysis with constant dialysate sodium versus acetate hemodialysis with sequential dialysate sodium. Artif Organs 9: 17, 1985PubMedCrossRefGoogle Scholar
  54. 54.
    Raja R, Kramer M, Barber K, Chen S: Sequential changes in dialysate sodium (DNa) during hemodialysis. Trans Am Soc Artif Intern Organs 29: 649, 1983PubMedGoogle Scholar
  55. 55.
    Muriasco A, France G, LeBlond G, Stroumza P, Durand C, Raynier JP, Crevat A, Elson R: Separation of Na+ and H2O transport during hemodialysis and quantification of high-low Na D1 levels during sequential therapy. Trans Am Soc Artif Intern Organs 29: 645, 1983Google Scholar
  56. 56.
    Henrich WL, Hunt JM, Nixon JV: Increased ionized calcium and left ventricular contractibility during hemodialysis. N Eng J Med 310: 19, 1985CrossRefGoogle Scholar
  57. 57.
    Ginsburg R, Esserman LJ, Brestow MR: Myocardial performance and extracellular ionized calcium in a severely failing human heart. Ann Intern Med 98: 603, 1983PubMedGoogle Scholar
  58. 58.
    Chaignon M, Chen WT, Tarazi RC, Nakamoto S, Salcedo E: Acute effects of hemodialysis on echocardiographic-determined cardiac performance: improved contractility resulting from serum increased calcium with reduced potassium despite hypovolemic-reduced cardiac output. Am Heart J 103: 374, 1982PubMedCrossRefGoogle Scholar
  59. 59.
    Schmidt M, Schoeppe W, Baldamus CA: Hemodynamics during dialysis with dialyzers of high hydraulic permeability. Contr Nephrol 46: 127, 1985Google Scholar
  60. 60.
    Koon KT, Basile C, Ulan RA, Hetherington MD, Kappagoda T: Effect of hemodialysis and hypertonic hemodiafiltration on cardiac function compared. Kidney Int 33: 399, 1987Google Scholar
  61. 61.
    Maynard JC, Cosme C, Kleerkoper M, Levin N: Blood pressure response to changes in serum ionized calcium during hemodialysis. Ann Intern Med Google Scholar
  62. 62.
    Mahida BH, Dumler F, Zasuwa G, Flug G, Levin NW: Effect of cooled dialysate on serum catecholamines and blood pressure stability. Trans Am Soc Artif Intern Organs 29: 384, 1983PubMedGoogle Scholar
  63. 63.
    Maggiore Q, Pizzarelli F, Zocalli C, Sisca S, Nicolo F, Pariango S: Effect of extracorporeal blood cooling on dialytic arterial hypotension. Proc Eur Dial Transplant Assoc 18: 597, 1981PubMedGoogle Scholar
  64. 64.
    Grossman F, Kopp KF: Thermo-osmotic effect and ultrafiltration in the artificial kidney – experience with the ‘ kidney’.Proc Eur Dial Transplant Assoc 3: 299, 1966Google Scholar
  65. 65.
    Quellhorst E, Ruzer J, Doht B, Beckmann H, Jacob I, Kraft B, Mietzsch G, Scheler F: Treatment of chronic uremia by an ultrafiltration kidney – first clinical experience. Proc Eur Dial Transplant Assoc 13: 314, 1976Google Scholar
  66. 66.
    Baldamus CA, Schoeppe W, Koch KM: Comparison of hemodialysis (HD) and post dilution hemofiltration (HF) on an unselected dialysis population. Proc Eur Dial Transplant Assoc 15: 228, 1978PubMedGoogle Scholar
  67. 67.
    Shaldon S, Beau MC, Deschodt G, Ramperez P, Mion C: Vascular stability during hemofiltration. Trans Am Soc Artif Intern Organs 26: 391, 1980PubMedGoogle Scholar
  68. 68.
    Wizemann V, Kramer W, Knopp G, Rawer P, Mueller K, Schuetterle G: Ultrashort hemodiafiltration: efficiency and hemodynamic tolerance. Clin Nephrol 19: 24, 1983PubMedGoogle Scholar
  69. 69.
    von Albertini B, Miller JH, Gardner PW, Shinaberger JH: Performance characteristics of the Hemoflow F-60 in high- flux hemodiafiltration. Contr Nephrol 46: 169, 1985Google Scholar
  70. 70.
    Miller JH, Shinaberger JH, Gardner PW: Extended ultrafiltration control. Trans Am Soc Artif Intern Organs 23: 244, 1977PubMedGoogle Scholar
  71. 71.
    Schmidt M, Baldamus CA, Schoeppe W: Backfiltration in hemodialyzers with highly permeable membranes. Blood Purif 2: 108, 1984CrossRefGoogle Scholar
  72. 72.
    Shinaberger JH, Miller JH, von Albertini B, Gardner PW, Coburn JW: Phosphate removal by conventional dialysis, high efficiency dialysis and high flux hemodiafiltration. Kidney Int 31: 245, 1987Google Scholar
  73. 73.
    Collins A, Ilstrup K, Hanson G, Berkseth R, Keshaviah P: Rapid high efficiency hemodialysis. Artif Organs 10:185,1986PubMedCrossRefGoogle Scholar
  74. 74.
    Basile C, Miller JDR, Koles ZJ, Grace M, Ulan RA: The effects of dialysis on brain water and EEG in stable chronic uremia. Am J Kidney Dis 9: 462, 1987PubMedGoogle Scholar
  75. 75.
    Keshaviah P, Collins A: Rapid high-efficiency hemodialysis. Trans Am Soc Artif Intern Organs 32: 17, 1986Google Scholar
  76. 76.
    Keshaviah P, Luehmann D, Ilstrup K, Collins A: Technical requirements for rapid H-efficiency therapies. Artif Organs 10: 189, 1986PubMedCrossRefGoogle Scholar
  77. 77.
    Rotellar E, Martinez E, Samso JM, Barrios J, Simo R, Mulero JF, Perez D, Bandrés S, Piñol J: Why dialyze more than 6 hours a week? Trans Am Soc Artif Intern Organs 31: 538, 1985PubMedGoogle Scholar
  78. 78.
    Rotellar E, Martinez E, Samso JM, Barrios J, Simo R, Mulero JF, Perez MD, Bandrés S, Piñol J: Large-surface Hemodialysis. Artif Organs 10: 387, 1986PubMedCrossRefGoogle Scholar
  79. 79.
    Saito A, Ogawa T, Takugi K, Ohta K, Akasu H, Kawai S, Kubotsu, A: A new approach to glomerular filtration. Trans Am Soc Artif Intern Organs 29: 673, 1983PubMedGoogle Scholar
  80. 80.
    Fresenius-Stiftung: Hochpermeable Membranen für die optimierte Therapie des Nierenversagens. (Highly permeable membranes for optimal therapy of renal failure.) Beiheft 1, 1985Google Scholar
  81. 81.
    Schneider H, Streicher E: Mass transfer characteristics of a new polysulfone membrane. Artif Organs 9: 180, 1985PubMedCrossRefGoogle Scholar
  82. 82.
    Rockel A, Hertel J, Fiegel P, Abdelhamid S, Panitz N, Walb D: Permeability and secondary membrane formation of a high-flux polysulfone hemofilter. Kidney Int 30: 429, 1986PubMedCrossRefGoogle Scholar
  83. 83.
    Chanard J, Lavaud S, Toupance O, Melin JP, Gillery P: ß2 microglobulin-associated amyloidosis in chronic haemodialysis patients. Lancet 1: 1212, 1986PubMedCrossRefGoogle Scholar
  84. 84.
    Caverle Y, Simon P, Ang K, Cam G, Catheline M: Serum ß2 microglobulin levels in hemodialyzed uremics depend on permeability of dialysis membranes. Kidney Int 31: 229, 1987Google Scholar
  85. 85.
    Levin NW, Dumler F, Stella K, Parnell S, Zasuwa BS: High flux dialysis – Henry Ford Hospital approach. Dial Transplant 15: 556, 1986Google Scholar
  86. 86.
    Acchiardo S, Burk L, Bannister D: High flux (HF) hemodialysis (HD). One year experience. Artif Organs 11: 301, 1987Google Scholar
  87. 87.
    Favero MS: CDC alert to potential microbiological and endotoxin risks. Nephrol News and Issues 6: 21, 1987Google Scholar
  88. 88.
    Henderson LW, Beans E: Successful production of sterile pyrogen-free electrolyte solution by ultrafiltration. Kidney Int 14: 522, 1978PubMedCrossRefGoogle Scholar
  89. 89.
    Henderson LW, Besarab A, Michaels AS, Bluemle LW: Blood purification by ultrafiltration and fluid replacement (Diafiltration). Trans Am Soc Artif Intern Organs 12: 216, 1967Google Scholar
  90. 90.
    Hüfler M, Asmus G, von Herrath D, Schaefer K: Hemodialysis or hemofiltration – the patients’ view. Blood Purif 5: 1, 1987PubMedCrossRefGoogle Scholar
  91. 91.
    Geronemus R, von Albertini B, Glabman S, Bosch JP: High flux hemofiltration: further reduction in treatment time. Proc Dial Transplant Forum 9: 125, 1979Google Scholar
  92. 92.
    Haas T, Dongradi G, Villeboeuf F, deViel E, Verrier J, Hillion D: Technical and clinical data on high performance hemofiltration: twelve patients during one year. Artif Organs 9: 164, 1985PubMedCrossRefGoogle Scholar
  93. 93.
    Cheung AK, Alford MF, Wilson MM, Leypoldt JK, Henderson LW: Urea movement across erythrocyte membrane during artificial kidney treatment. Kidney Int 23: 866, 1983PubMedCrossRefGoogle Scholar
  94. 94.
    Villaroel F, Klein E, Holland F: Solute flux in hemodialysis and hemofiltration membranes. Trans Am Soc Artif Intern Organs 23: 225, 1977Google Scholar
  95. 95.
    Sigdell JE: Calculation of combined diffusive and convective transfer. Int J Artif Organs 5: 361, 1982PubMedGoogle Scholar
  96. 96.
    Weryński A: Evaluation of the impact of ultrafiltration on dialyzer clearance. Artif Organs 3: 140, 1979PubMedCrossRefGoogle Scholar
  97. 97.
    Kunitomo T, Lowrie EG, O’Brien M, Lazarus JM, Gottlieb MN, Kumigawa S, Merrill JP: Performance and clinical use of a convective hemodialysis (HD) -ultrafiltration (HF) system. Proc Dial Transplant Forum 6: 120, 1976Google Scholar
  98. 98.
    Kunitomo T, Kirkwood RG, Kumigawa S, Lazarus JM, Gottlieb MN, Lowrie EG: Clinical evaluation of a postdilution dialysis with a combined ultrafiltration (UF) -hemodialysis (HD) system. Trans Am Soc Artif Intern Organs 24:169,1978PubMedGoogle Scholar
  99. 99.
    Leber HW, Wizemann V, Goubeaud G, Rawer P, Schütterle G: Simultaneous hemofiltration/hemodialysis: an effective alternative to hemofiltration and conventional hemodialysis in the treatment of uremic patients. Clin Nephrol 9: 115, 1978PubMedGoogle Scholar
  100. 100.
    Dieter V, Franz HE, Breitag D, Meyer C, Schmidt-Wiederkehr P: Blut detoxification durch simultane Dialyse und Diafiltration. (Blood detoxification by simultaneous dialysis and diafiltration.) Biomed Techn 22: 277, 1977CrossRefGoogle Scholar
  101. 101.
    Wizemann V, Rawer P, Schütterle G: Ultrashort hemodiafiltration: long term efficiency and hemodynamic tolerance. Proc Eur Dial Transplant Assoc 19:175,1982Google Scholar
  102. 102.
    Wizemann V: Hemodiafiltration – to be or not to be? The Giessen experience. Blood Purif 2: 76, 1984CrossRefGoogle Scholar
  103. 103.
    Ota K, Suzuki T, Ozaku Y, Hoshino T, Agishi T, Sugino N: Short – time hemodiafiltration using polymethylmethacrylate hemodiafilter. Trans Am Soc Artif Intern Organs 24:454,1978PubMedGoogle Scholar
  104. 104.
    Miller JH, Shinaberger JH, Kraut JA, Gardner PW: A volume controlled apparatus for ultrafiltration and hemofiltration with acetate or bicarbonate solutions. Trans Am Soc Artif Intern Organs 25: 404, 1979PubMedGoogle Scholar
  105. 105.
    Miller JH: Experience with the RP610 and Filtral 7+8 used for simultaneous hemofiltration and hemodialysis. Proc 1st Am AN69 Membr Sci Exch 1:113,1982Google Scholar
  106. 106.
    Zuchelli P, Santoro A, Raggiotto G, Esposti ED, Sturani A, Capecchi V: Bio-filtration in uremia: preliminary observations. Blood Purif 2: 187, 1984CrossRefGoogle Scholar
  107. 107.
    Cioni L, Pilone N, Rindi P: Fast safe hemodiafiltration: less than 4 hours/week. Blood Purif 2: 206, 1984CrossRefGoogle Scholar
  108. 108.
    Wizemann V, Techert F, Schütterle G: High efficiency on line hemofiltration (HF) or hemodiafiltration (HDF) performed with a dialysis machine. Blood Purif 2: 206, 1984CrossRefGoogle Scholar
  109. 109.
    Rossi R, Farma A, Mino retti C, Colantonio G, Ferradini MA, Martinelli D, Giura C, Quarenghi MI: Short time hemodiafiltration using two joined dialyzers of different membranes: results after 5000 treatments. Blood Purif 2: 211, 1984Google Scholar
  110. 110.
    Ghezzi PM, Zucchelli P, Botella J, Koutsikos D, Marazzi F, Canepari G, Nigrelli S, Spongano M, Ziroyannis P, Santaro A: Paired filtration dialysis (PFD), an alternative to classical hemodiafiltration (HDF). Blood Purif 2: 203, 1984Google Scholar
  111. 111.
    von Albertini B, Miller JH, Gardner PW, Roberts CE, Shinaberger JH: One year high flux hemodiafiltration: 6hrs/week. Abstracts Am Soc Nephrol 18: 78A, 1985Google Scholar
  112. 112.
    Usuda M, Shinzato T, Sezaki R, Kawanishi A, Maeda K, Kawaguchi S, Shibata M, Toyoda T, Asakura Y, Ohbayashi S: New simultaneous HF and HD with no infusion fluid. Trans Am Soc Artif Intern Organs 28: 24, 1982PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • James H. Shinaberger
  • Joseph H. Miller
  • Peter W. Gardner

There are no affiliations available

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