Experience of the University of Genoa, Transplant Unit, Genoa, Italy
Our experience with pancreas transplantation in man from 1978 to 1986 is represented by 3 segmental autotransplantations and 14 segmental and whole pancreas transplantations. In the same time we have developed the islet isolation technique carrying out 24 autotransplantations, 16 adult islet transplantations in diffusion chambers, 13 fetal pancreas transplantations and 5 adult islet transplantations after treatment with monoclonal antibodies. The 3 segmental autotransplantations were performed between 1978 and 1979 after 95% pancreatectomy for chronic pancreatitis using the injected duct technique by Neoprene sec. Dubernard. In all cases the graft was anatomozed to femoral vessels in the inguinal region. In all cases we observed a pancreatic fistula alsting respectively 60–14–10 days and in 1 case there was a hemorrage on the 5th day. The endocrine function of the graft was assessed with O.G.T.T, I.V.G.T.T., Arginine test, Glucagon test, with simultaneous sampling for glycemia, insulinemia and C-peptide. After a follow-up of 8 years, 2 of the 3 patients are still functioning with a satisfactory response as above. The third patient began the insulin therapy after 2 years of normal function.
KeywordsPancreatic Fistula Transplant Proc Pancreas Transplantation Diffusion Chamber Pancreatic Transplantation
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- 3.Calne RY, Brons IGM: Observations on paratopic segmental pancreatic grafting with splenic venous drainage. Transplant Proc 17: 340, 1985.Google Scholar
- 4.Dubernard JM, Traeger J, Piatti PM et al: Report of 54 segmental pancreatic allograft prepared by duct obstruction with Neoprene. Transplant Proc 17, 312, 1986.Google Scholar
- 5.Gil-Vernet JM, Fernandez-Cruz L, Andreu D et al: Clinical experience with pancreat- icopyelodtomy for exocrine pancreatic drainage and portal venous drainage in pancreas transplantation. Transplant Proc 17: 342, 1985.Google Scholar
- 6.Land W, Landgraf R, Illner WD et al: Improved results in combined segmental pancreatic and renal transplantation in diabetic patients under cyclosporin therapy using ethibloc for duct obliteration. Transplant Proc 17: 317, 1985.Google Scholar
- 7.Munda R, First MR, Joffe SN et al: Experience with pancreatic allograft in renal transplant recipients with segmental pancreatic allograft. Transplant Proc 17: 353, 1986.Google Scholar
- 8.Sollinger H, Kalayoglu M, Hoffman RM et al: Result of segmental and pancreaticosplenic transplantation with pancreaticocystomy. Transplant Proc 17: 360, 1985.Google Scholar
- 9.Sutherland DER, Goetz FC, Kendall DM et al: Effect of donor source, technique, immunosuppression and presence or absence of end stage diabetic nephropathy on outcome in pancreas transplantation recipients. Transplant Proc 17: 325, 1985.Google Scholar
- 11.Sutherland DER, Kendall D: Clinical pancreas and islet transplant reistry report. Transplant Proc 17: 307, 1985.Google Scholar
- 14.Tyden G, Wilczek H, Lundgren G et al: Experience with 21 intraperitoneal segmental pancreatic transplants with enteric or gastric exocrine diversion in human. Transplant Proc 17: 331, 1985.Google Scholar
- 15.Valente U, Barabino C, Barocci S et al: Segmental pancreatic transplantation in diabetics: follow-up in eight patients. Transplant Proc 17: 349, 1985.Google Scholar