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Experience of the University of Barcelona

  • L. Fernández-Cruz
  • J. M. Gil-Vernet
  • J. Andreu
  • E. Esmatges
  • E. M. Targarona
Part of the Developments in Surgery book series (DISU, volume 10)

Abstract

Pancreas transplantation for the treatment of diabetes mellitus has proven increasingly successful in recent years. The handling of the exocrine pancreatic secretion has been a subject of controversy. Satisfactory results have een achieve with diversion to the stomach and the intestine [1,2]. However, one of the main problems of clinical pancreas transplantation is the lack of reliable technique for early diagnosis of rejection, particularly in non-simultaneous pancreas and kidney transplants where the only valid parameter has been an increase in the plasma glucose concentrations. A rise in plasma glucose levels ha been demonstrated to be a late indicator of pancreas allograft rejection, both experimentally and clinically [3]. Converesly, simultaneous kidney and pancreas transplantation from the same donor has the advantages of allowing the pancreas to be indirectly monitored for possible rejection by assissing kidney function through serum creatinine levels or renal biopsy.

Keywords

Transplant Proc Pancreas Transplantation Splenic Vessel Exocrine Pancreatic Secretion Pancreas Graft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Brons IGM, Calne RY, Rolles K, Olczak S, Evans DB: Paratopic segmental pancreas with simultaneous kidney transplantation in man: a 1 year follow-up study. Transplant Proc 18: 1129,1986.Google Scholar
  2. 2.
    Tyden G, Mellgren A, Brattstöm C, Ost L, Gunnarsson R, Ostman J, Groth CG: Stockholm experience with 32 combined renal and segmental pancreatic transplants. Transplant Proc 18: 1114, 1986.Google Scholar
  3. 3.
    Prieto M, Sutherland DER, Fernández-Cruz L, Heil J, Najarian J: Urinary amylase monitoring for early diagnosis of pancreas allograft rejection in dogs. J Surg Res 40: 597–604 1986.Google Scholar
  4. 4.
    Gliedman M.L., Gold M, Whittacker J, Rifkin H, Soberman R, Selwyn F, Tellis V, Veith F: Clinical segmental pancreatic transplantation with ureter-pancreatic duct anastomosis for exocrine drainage. Surgery 74: 171, 1973.Google Scholar
  5. 5.
    Sollinger HW, Kamps D, Cook K, Warner T, Belzer FO: Results of segmental and pancreatico-splenic transplantation with pancreatico-cystostomy. Transplant Proc 15: 2997, 1983.Google Scholar
  6. 6.
    Gil-Vernet JM, Fernández-Cruz L, Andreu J, Figuerola D, Caralps A: Clinical experience with pancreaticopyelostomy for exocrine pancreatic drainage and portal venous drainage in pancreas transplantation. Transplant Proc 17: 342, 1985.Google Scholar
  7. 7.
    Gil-Vernet JM, Fernández-Cruz L, Caralps A, Andreu J, Figuerola D: Whole organ and pancreaticoureterostomy in clinical pancreas transplantation. Transplant Proc 17: 2019, 1985.Google Scholar
  8. 8.
    Nghiem DD, Gouwa TA, Corry RJ: Metabolic effects of urinary diversion of exocrine secretions in pancreas transplantation. Transplantation 43: 70,1987.Google Scholar
  9. 9.
    Gil-Vernet JM, Fernández-Cruz L, Andreu J, Figuerola D, Caralps A: Urinary tract diversion in clinical pancreas transplantation. Transplant Proc 18: 1132, 1986.Google Scholar
  10. 10.
    Prieto M, Sutherland DER, Fernández-Cruz L, Heil J, Nanjarian J: Experimental and clinical experience with urine amylase monitoring for early diagnosis of rejection in pancreas transplantation. Transplantation 43: 73, 1987.Google Scholar
  11. 11.
    Tyden G, Wilczek H, Lundren G, Ostman J: experience with 21 intraperitoneal segmental pancreatic transplants with enteric or gastric exocrine diversion in humans. Transplant Proc 17:331,1985.Google Scholar
  12. 12.
    Landgraf R, Landgrag-Leurs MMC, Burg D, Kampik A, Castro LA, Abendroth A, Illner WD, Land W: Long-term follow-up of segmental pancreas transplantation in type I diabetics. Transplant Proc 18: 1118,1986.Google Scholar
  13. 13.
    Sutherland DER, Goetz FC, Mondry KC, Abouna GM, Najarian JS: Use of recipient mesenteric vessels for revascularization of segmental pancreatic grafts: technical and metabolic considerations. Transplant Proc 19: 2300, 1987.Google Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • L. Fernández-Cruz
  • J. M. Gil-Vernet
  • J. Andreu
  • E. Esmatges
  • E. M. Targarona

There are no affiliations available

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