Introduction and history of pancreatic transplantation

  • J. M. Dubernard
  • D. E. R. Sutherland
Part of the Developments in Surgery book series (DISU, volume 10)


In type I diabetes mellitus, insulin production by the pancreas progressively declines and ultimately disappears, as the Beta cells within the islets of Langerhans are destroyed by an autoimmune process resulting from a complex interplay between genetic and unknown environmental factors [1]. Searches for methods of total endocrine replacement therapy theoretically superior to simple exogenous insulin administration have taken three directions: 1) Connection to or implantation of an artificial (mechanical) pancreas, mimicking the betacell in its response to the need for and delivery of insulin; 2) transplantation of isolated islets as free grafts; and 3) solid organ, immediately vascularized pancreas transplantation. The first two approaches are currently impractical or ineffective in clinical practice, whereas the third has rapidly progressed during the past decade, to the point where its application is even becoming routine in a selected population of diabetic patients.


Diabetic Nephropathy Islet Transplantation Pancreas Transplantation Pancreatic Transplantation Pancreas Graft 
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© Kluwer Academic Publishers 1989

Authors and Affiliations

  • J. M. Dubernard
  • D. E. R. Sutherland

There are no affiliations available

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