Introduction and history of pancreatic transplantation

  • J. M. Dubernard
  • D. E. R. Sutherland
Part of the Developments in Surgery book series (DISU, volume 10)

Abstract

In type I diabetes mellitus, insulin production by the pancreas progressively declines and ultimately disappears, as the Beta cells within the islets of Langerhans are destroyed by an autoimmune process resulting from a complex interplay between genetic and unknown environmental factors [1]. Searches for methods of total endocrine replacement therapy theoretically superior to simple exogenous insulin administration have taken three directions: 1) Connection to or implantation of an artificial (mechanical) pancreas, mimicking the betacell in its response to the need for and delivery of insulin; 2) transplantation of isolated islets as free grafts; and 3) solid organ, immediately vascularized pancreas transplantation. The first two approaches are currently impractical or ineffective in clinical practice, whereas the third has rapidly progressed during the past decade, to the point where its application is even becoming routine in a selected population of diabetic patients.

Keywords

Diabetic Nephropathy Islet Transplantation Pancreas Transplantation Pancreatic Transplantation Pancreas Graft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1..
    Eisenbarth GS: Type I diabetes mellitus: A chronic autoimmune disease. New Engl J Med 314: 1360 – 1368, 1986.PubMedCrossRefGoogle Scholar
  2. 2..
    LaPorte RE, Tajima N: Prevalence of insulin-dependent diabetes, diabetes in America (editors Harris MI and Hamman RF for national diabetes data group, NIADDK) NIH pub. no. 85–1468, U.S. dept health and human services, chapter V, pp 1 – 8, 1985.Google Scholar
  3. 3..
    LaPorte RE: Cruickshanks; Incidence and risk factors for insulin-dependent diabetes, diabetes in America (editors Harris MI and Hamman RF for national diabetes data group, NIADDK) NIH pub. no. 85–1468, U.S. dept health and human services, chapter III, pp 1 – 12, 1985.Google Scholar
  4. 4..
    Harris MI, Hanaman RF (eds): Diabetes in America NIH publication 85–1468, Bethesda, Maryland 1985.Google Scholar
  5. 5..
    Krolewski AS, Warram JH, Rand LI et al: Epidemiologic approach to the etiology of type I diabetes mellitus and its complications. N Engl J Med 317: 1390 – 1398, 1987.PubMedCrossRefGoogle Scholar
  6. 6..
    Goetz FC, Elick B, Fryd D, Sutherland DER: Renal transplantation in diabetes. Clinics in Endocrinology and Metabolism 15: 807 – 821, 1986.PubMedCrossRefGoogle Scholar
  7. 7..
    Sutherland DER, Moudry KC: Pancreas transplant registry: history and analysis of cases 1966 to October 1986. Pancreas 2: 473 – 488, 1987.PubMedCrossRefGoogle Scholar
  8. 8..
    Tchobroutsky G: Relation of diabetes control to Development of microvascular complications. Diabetologia 15: 143 – 152, 1978.PubMedCrossRefGoogle Scholar
  9. 9..
    Hanssen KF, Dahl-Jorgenson K, Lauritzen J et al: Diabetic control and microvascular complications: the near normoglycemic experience. Diabetologia 10: 677 – 684, 1986.CrossRefGoogle Scholar
  10. 10..
    Service JS, Molnar GD, Rosevar JE, et al: Mean amplitude of glycemic excursions, a measure of diabetes instability. Diabetes 19: 644 – 655, 1970.PubMedGoogle Scholar
  11. 11..
    Ungar RH: Meticulous control of diabetes: Benefits, risks and precautions. Diabetes 31: 479, 1982.Google Scholar
  12. 12..
    Pirart J: Diabetes mellitus and its degenerative complications: A prospective study of 4,400 patients observed between 1947 and 1973. Diabetes Care 1: 168 – 188, 1978.Google Scholar
  13. 13..
    Passa P, Rousselie F, Gauville C, Canivet J: Retinopathy in idiopathic hemochromatosis with diabetes. Diabetes 26: 2: 113 – 120, 1977.PubMedCrossRefGoogle Scholar
  14. 14..
    Doyle AP, Balcerzak SP, Jeffrey WL: Fatal diabetic glomerulosclerosis after total pancreatectomy. N Engl J Med 270: 623 – 624, 1964.PubMedCrossRefGoogle Scholar
  15. 15..
    Salans LB, Graham BJ: Proceedings of a task force on animals appropriate for studying diabetes mellitus and its complications. Diabetes 31 (Supplement 1): 1 – 95, 1982.Google Scholar
  16. 16..
    Mauer SM, Sutherland DER, Steffes MW, et al: Pancreatic transplantation: Effects on the glomerular lesions of experimental diabetes in the rat. Diabetes 23: 748 – 753, 1974.PubMedGoogle Scholar
  17. 17..
    Orloff MJ, Yamanaka N, Greenleaf G, et al: Reversal of mesangial enlargement in rats with long-standing diabetes by whole pancreas transplantation. Diabetes 35: 347 – 354, 1986.PubMedCrossRefGoogle Scholar
  18. 18..
    Orloff MJ, Maceto D, Greenleaf GE, et al: Effect of Pancreas transplantation of diabetic somatic neuropathy. Surgery 104: 437 – 444, 1988.PubMedGoogle Scholar
  19. 19..
    Lee CS, Mauer SM, Brown DM, Sutherland DER, Michael AF, Najarian JS: Renal transplantation in diabetes mellitus in rats. J Exp Med 139: 793 – 800, 1974.PubMedCrossRefGoogle Scholar
  20. 20..
    Mauer SM, Steffes MW, Connett J, et al: Development of lesions in the glomerular basement membrane and mesangium after transplantation of normal kidneys to diabetic patients. Diabetes 32: 948 – 952, 1983.PubMedCrossRefGoogle Scholar
  21. 21..
    Abouna GM, Al-Adnani MSA, Kremer GM, et al: Reversal of diabetic nephropathy in human cadaveric kidneys after transplantation into nondiabetic recipients. Lancet 2: 1274– 1276, 1983.PubMedCrossRefGoogle Scholar
  22. 22..
    Bohman SO, Tyden G, Wilezek A: Prevention of kidney graft diabetic nephropathy by pancreas transplantation in man. Diabetes 34: 306, 1985.PubMedCrossRefGoogle Scholar
  23. 23..
    Bilous RW, Mauer SM, Sutherland DER, Steffes MW: Glomerular structure and function following successful pancreas transplantation for insulin-dependent diabetes mellitus. Diabetes 36: 43A, 1987. Nephropathy by Pancreas Transplantation in Man. Diabetes 34: 306, 1985.Google Scholar
  24. 24..
    van der Vliet JA, Navarro X, Kennedy WR, Goetz FC, Najarian JS, Najarian JS: The effect of pancreas transplantation on diabetic polyneuropathy. Transplantation 45: 368 – 370, 1988.PubMedCrossRefGoogle Scholar
  25. 25..
    Ulbig M, Kampik A, Landgraf R, Land W: The influence of combined pancreatic and renal transplantation on advanced diabetic retinopathy. Transpl Proc 19: 3554 – 3556, 1987.Google Scholar
  26. 26..
    Ramsay RC, Goetz FC, Sutherland DER, Mauer SM, Robinson LL, Cantrill HL, Knobloch WH, Najarian JS: Progression of diabetic retinopathy after pancreas transplantation for insulin-dependent diabetes mellitus. H N Eng J Med 318: 208 – 214, 1988.CrossRefGoogle Scholar
  27. 27..
    Sutherland DER, Kendall DM, Moudry KC, Navarro X, Kennedy WR, Ramsay RC, Steffes MW, Mauer SM, Goetz FC, Dunn DL, Najarian JS: Pancreas transplantation in nonuremic, type I diabetic recipients. Surgery 104: 453 – 464, 1988.PubMedGoogle Scholar
  28. 28..
    von Mering J, Minkowski O: Diabetes mellitus nach pancreas extirpation. Arch Exp Pathol Pharmakol 26: 371 – 379, 1889.Google Scholar
  29. 29..
    Hedon E. Sur la consommation du sucre ches le chien apres l’extirpation du pancreas. Arch Physiol Norm Pathol 5: 154 – 163, 1893.Google Scholar
  30. 30..
    Bliss M: The discovery of insulin. The univ. of Chicago press., 1982.Google Scholar
  31. 31..
    Najarian JS, Kjellstrand CM, Simmons RL et al: Renal transplantation for diabetic glomerulosclerosis. Ann Surg 178: 477 – 485, 1973.PubMedCrossRefGoogle Scholar
  32. 32..
    Witkin SR, Klein R: Optholmologic care for people with diabetes. J Am Med Assoc 251– 2534 – 37, 1984.Google Scholar
  33. 33..
    Gayet R, Guillaumie M: La regulation de la secretion interne pancreatique par un processus normalisateur demontree par des transplantations de pancreas. Cr Soc Biol 97: 1613 – 1627, 1877.Google Scholar
  34. 34..
    Houssay BA: Technique de la greffe pancreaticoduodenale an cou. C.R. Soc. Biol. (Paris) 100: 138 – 140, 1929.Google Scholar
  35. 35..
    Lexer E. Die freien transplantationen. Ferdinand Enke, Stuttgart 1919.Google Scholar
  36. 36..
    Brooks JR, Gifford GH: Pancreatic homotransplantation. Transplant Bull 6: 100 – 103, 1959.PubMedCrossRefGoogle Scholar
  37. 37..
    DeJode LR, Howard JM: Studies in Pancreaticoduodenal homotransplantation. Surg Gyn Obst 114: 553 – 58, 1962.PubMedGoogle Scholar
  38. 38..
    Largiader F, Lyons GW, Hidalgo F, et al: orthotopic allotransplantation of the pancreas. Am J Surg 113: 70 – 76, 1967.PubMedCrossRefGoogle Scholar
  39. 39..
    Lillehei RC, Simmons RL, Najarian JS, et al: Pancreatico-duodenal allotransplantation: Experimental and clinical experience. Ann Surg 172: 405 – 436, 1970.PubMedCrossRefGoogle Scholar
  40. 40..
    Sutherland DER: Pancreas transplantation: an update. In Alberti KGMM, Krall LP (eds) Diabetes Annual/3; pp 159 – 188. Elsevier Science Publishers, Amsterdam, 1987.Google Scholar
  41. 41..
    Kelly, WD, Lillehei RC, Merkel FK, Idezuki Y, Goetz FC: Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery 61: 827, 1967.PubMedGoogle Scholar
  42. 42..
    Lillehei RC, Ruiz JO, Acquino C, Goetz FC: Transplantation of the pancreas. Acta Endocrinol 83 (Suppl 205): 303, 1976.Google Scholar
  43. 43..
    Sutherland DER, Goetz FC, Carpenter AM, Najarian JS, Lillehei RC: Pancreaticoduodenal grafts: clinical and pathological observations in uremic versus nonuremic recipients. In: Touraine JL, Traeger J, Betuel H, Brochier J, Dubernard JM, Revillard JP, Triau R (eds): Transplantation and clinical immunology; vol X, pp 190 – 195. Excerpta Medica, Amsterdam- Oxford, 1979.Google Scholar
  44. 44..
    Najarian JS, Sutherland DER, Simmons RL, Howard RJ, Kjellstrand CM, Ramsay RC, Goetz FC, Fryd DS, Sommer BG: A ten year experience in kidney transplantation in juvenile onset insulin dependent diabetics. Ann Surg 190: 487 – 500, 1979.PubMedCrossRefGoogle Scholar
  45. 45..
    Gliedman ML, Gold M, Whittaker J, Rifkin H, Soberman R, Freed S, Tellis V, Veith FJ: Clinical segmental pancreatic transplantation with ureter-pancreatic duct anastomosis for exocrine drainage. Surgery 74: 171 – 180, 1973.PubMedGoogle Scholar
  46. 46..
    Groth CG, Lundgren G, Arner P, Cellste H, Hardstedt C, Lewander R, Ostman J: Rejection of isolated pancreatic allografts in patients with diabetes. Surg Gynecol & Obstet 143: 933 – 940, 1976.Google Scholar
  47. 47..
    Largiader F, Uhlschmid G, Binswanger U, et al: Pancreas rejection in combined pancreaticoduodenal and renal allotransplantation in man. Transplantation 19: 185 – 187, 1975.PubMedCrossRefGoogle Scholar
  48. 48..
    Gliedman ML, Tellis VA, Soberman R, et al: Long-term effects on pancreatic transplant function in patients with advanced juvenile onset diabetes. Diabetes Care 1: 1 – 9, 1978.PubMedCrossRefGoogle Scholar
  49. 49..
    American college of surgeons/national institute of health: organ transplant registry: first scientific report. JAMA 217: 1520–1529,1971.Google Scholar
  50. 50..
    Sutherland DER: International Human pancreas and islet transplant registry. Transpl Proc 12 (No. 4, Suppl 2): 229 – 236, 1980.Google Scholar
  51. 51..
    Ballinger WF, Lacy PE: Transplantation of intact pancreatic islets in rats. Surgery 72: 175, 1972.PubMedGoogle Scholar
  52. 52..
    Sutherland DER: pancreas and islet transplantation. I. Experimental studies. Diabetologia 20:161–85,1981.Google Scholar
  53. 53..
    Sutherland DER: Pancreas and islet transplantation. II. Clinical results. Diabetologia 20: 435 – 50, 1981.PubMedGoogle Scholar
  54. 54..
    Sutherland DER, Matas AJ, Najarian JS: Pancreatic islet cell transplantation. Surg Clinics of No Amer 58: 365 – 382, 1978.Google Scholar
  55. 55..
    Sutherland DER, Matas AJ, Goetz FC, Najarian JS: Transplantation of dispersed pancreatic islet tissue in humans: Autografts and allografts. Diabetes 29 (suppl 1): 31 – 44, 1980.PubMedGoogle Scholar
  56. 56..
    Scharp DW, Lacy PE: Human islet isolation and transplantation. Diabetes 34 (suppl 1 ): 5A, 1985.Google Scholar
  57. 57..
    Lacy PE: Islet transplantation. In: Alberti KGMM, Krall LP (eds) The diabetes annual/3; pp 189 – 200. Elsevier Science Publishers, Amsterdam, 1987.Google Scholar
  58. 58..
    Scharp DW, Lacy PE, Finke E, et al: Low temperature culture of human islets isolated by the distention method and purified with ficoll or percoll gradients. Surgery. 102: 869 – 879, 1987.PubMedGoogle Scholar
  59. 59..
    Dubernard JM, Traeger J, Neyra P, Touraine JL, Tranchant D, Blanc-Brunat N: A new method of preparation of segmental pancreatic grafts for transplantation: trials in dogs and in man. Surgery 84: 633 – 640, 1978.PubMedGoogle Scholar
  60. 60..
    Land W, Landgraff R: clinical pancreas transplantation, the world experience: Proceedings of the second international workshop on clinical pancreas transplantation. Transp Proc 19 (Suppl 4): 1 – 45, 1987.Google Scholar
  61. 61..
    Sollinger HW, Cook K, Kamps D, Glass NR, Belzer FO: Clinical and experimental experience with pancreaticocystostomy for exocrine pancreatic drainage in pancreas transplantation. Transpl Proc 16: 749 – 531, 1984.Google Scholar
  62. 62..
    Sollinger H, Kalayoglu M, Hoffman RM et al: Experience with whole pancreas transplantation and pancreaticoduodenocystostomy. Transpl proc 18: 1759 – 1761, 1986.Google Scholar
  63. 63..
    Groth CG, Collste H, Lundgren G et al: Successful outcome of segmental human pancreatic transplantation with enteric exocrine diversion after modifications in technique. Lancet 2: 522 – 524, 1982PubMedCrossRefGoogle Scholar
  64. 64..
    Tyden G, Reinholt G, Brattstrom C et al: Diagnosis of rejection in recipients of pancreatic grafts with enteric exocrine diversion by monitoring pancreatic juice cytology and amylase excretion. Transpl Proc 19: 3892 – 3894, 1987.Google Scholar
  65. 65..
    Thiroloix J., Le diabete pancreatique masson ed, Paris 1892.Google Scholar
  66. 66..
    Blanc-Brunat N, Dubernard JM, Touraine JL, et al: Pathology of the pancreas after intraductal neoprene injection in dogs and diabetic patients treated by pancreatic transplantation. Diabetologia 25: 97, 1983.PubMedCrossRefGoogle Scholar
  67. 67..
    Sibley RK, Sutherland DER: Pancreas transplantation: An immunohistological and histopathologic examination of 100 grafts. Am J Pathol 128: 151 – 170, 1987.PubMedGoogle Scholar
  68. 68..
    Sutherland DER, Goetz FC, Najarian JS: One hundred pancreas transplants at a single institution. Ann Surg 200: 414 – 440, 1984.PubMedCrossRefGoogle Scholar
  69. 69..
    Starzl TE, Hakali TR, Shaw BW et al: A flexible procedure for multiple cadaveric organ procurement. Surg Gynecol Obstet 158: 223 – 230, 1984.PubMedGoogle Scholar
  70. 70..
    Corry RJ, Nghiem DD, Schulak JA, Beutell WD, Gonwa TA: Surgical treatment of diabetic nephropathy with simultaneous pancreatic duodenal and renal transplantation. Surg Gyn Obstet 162: 547 – 555, 1986.Google Scholar
  71. 71..
    Prieto M, Sutherland DER, Goetz FC et al: Pancreas transplant results according to technique of duct management: Bladder versus enteric drainage. Surgery 102: 680 – 691, 1987.PubMedGoogle Scholar
  72. 72..
    Sutherland DER, Goetz FC, Najarian JS: Intraperitoneal transplantation of immediately vascularized segmental pancreatic grafts without duct ligation: A clinical trial. Transplantation 28: 485 – 491, 1979.PubMedGoogle Scholar
  73. 73..
    Sutherland DER, Goetz FC, Najarian JS: Pancreas transplants from related donors. Transplantation 38: 625 – 633, 1984.PubMedCrossRefGoogle Scholar
  74. Sutherland DER, Sibley R, Zu X-Z, Michael A, Srikanta S, Taub F, Najarian J, Goetz FC: Twin-to-twin pancreas transplantation: Reversal and reenactment of the pathogenesis of type I diabetes. Trans Assoc Amer Phys XCVII: 80 – 87, 1984.Google Scholar
  75. 75..
    Sutherland DER, Goetz FC, Elick BA, Najarian JS: Experience with 49 segmental pancreas transplants in 45 diabetic patients. Transplantation 34: 330 – 338, 1982.PubMedCrossRefGoogle Scholar
  76. 76..
    Sibley RK, Sutherland DER, Goetz, FC, Michael AF: Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Laboratory investigation. 53: 132 – 144, 1985.PubMedGoogle Scholar
  77. 77..
    Sutherland DER, Goetz FG, Moudry KC, Najarian JS: Pancreatic transplantation - a single institution’s experience. Diabetes, Nutrition and Metabolism 1: 57 – 66, 1988.Google Scholar
  78. 78..
    Dubernard JM, Traeger J: Transplantation of the pancreas. Transplant proc 12 (suppl 2): 1, 1980.Google Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • J. M. Dubernard
  • D. E. R. Sutherland

There are no affiliations available

Personalised recommendations