Skip to main content

Silent myocardial ischemia on ambulatory Holter monitoring and exercise testing: detection, characteristics and significance

  • Chapter
Book cover Electrocardiography and Cardiac Drug Therapy

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 92))

  • 62 Accesses

Abstract

The pioneer of ambulatory long-term monitoring of the electrocardiogram Norman J. Holter [1] described already in his first publication in 1961 ischemic changes during daily activities. A few years later, Norland and Semler [2] and Corday and coworkers [3] stressed that not only arrhythmias but also angina pectoris can be documented by telemetry. In spite of this, for almost 10 years no further advance was made in this field, mainly due to the caution advocated in 1967 by Hinkle [4] concerning the poor low-frequency response of the recorders available at that time. However, improvements and modifications made by manufacturers led to an adequate low-frequency response in the newer tape recorders [5]. Since then many investigators started to use the Holter tapes to study the frequency of ischemic episodes under dynamic conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. Holter NJ (1961) New method for heart studies continuous electrocardiography of active subjects. Science 134:1214–20

    Article  PubMed  CAS  Google Scholar 

  2. Norland CC, Semlar HJ (1964) Angina pectoris and arrhythmias documented by cardiac telemetry. JAMA 190:115

    PubMed  CAS  Google Scholar 

  3. Corday E, Bazika V, Lang TW, Pappelbaum S, Gold II, Bernstein H (1965) Detection of phantom arrhythmias and evanescent electrocardiographic abnormalities. JAMA 133:417

    Google Scholar 

  4. Hinkle Jr L, Meyer J, Stevens M, Carver ST (1967) Taperecordings of the ECG of active man. Circulation 36:752

    PubMed  Google Scholar 

  5. Stern S, Tzivoni D (1972) The reliability of the Holter-Avionics system in reproducing the ST-T segment. Am Heart J 84:427

    Article  PubMed  CAS  Google Scholar 

  6. Stern S, Tzivoni D (1974) Early detection of silent ischemic heart disease by 24-hour electrocardiographic monitoring of active subjects. Br Heart J 36:481

    Article  PubMed  CAS  Google Scholar 

  7. Stern S, Tzivoni D, Stern Z (1975) Diagnostic accuracy of ambulatory ECG monitoring, as validated by coronary arteriography. Circulation 52:1045

    PubMed  CAS  Google Scholar 

  8. Allen RD, Gettes LS, Phalan C, Avington MD (1976) Painless ST-segment depression in patients with angina pectoris. Chest 69:467–73

    Article  PubMed  CAS  Google Scholar 

  9. Schang SJ, Pepine CJ (1977) Transient asymptomatic ST segment depression during daily activity. Am J Cardiol 39:396–402

    Article  PubMed  Google Scholar 

  10. Linhart JW (1972) Atrial pacing in coronary artery disease, including pre-infarction angina and postoperative studies. Am J Cardiol 30:603

    Article  PubMed  CAS  Google Scholar 

  11. Guazzi M, Polese A, Fiorenti C, Magrini F, Olivari MI, Bartorelli C (1975) Left and right heart hemodynamics during spontaneous angina pectoris. Comparison between angina with ST segment depression and angina with ST segment elevation. Br Heart J 37:401

    Article  PubMed  CAS  Google Scholar 

  12. Biagini A, l’Abbate A, Maseri A (1982) Vasospastic ischemic mechanisms of frequent asymptomatic transient ST-T changes during continuous ECG monitoring. Am Heart J 103:13

    Article  PubMed  CAS  Google Scholar 

  13. Chierchia S, Brunelli C, Simonetti I, Lazzari M, Maseri A (1980) Sequence of events in angina at rest: primary reduction in coronary flow. Circulation 61:759

    PubMed  CAS  Google Scholar 

  14. Deanfield JE, Shea M, Ribiero P, De Landsheere CM, Wilson RA, Horlock P, Selwyn PA (1984) Transient ST-segment depression as a marker of myocardial ischemia during daily life. Am J Cardiol 54:1195

    Article  PubMed  CAS  Google Scholar 

  15. Cohn PF, Brown EJ, Wynne J, Halman BL, Atkins HL (1983) Global and regional left ventricular ejection farction abnormalities during exercise in patients with silent myocardial ischemia. J Am Cardiol 1:931

    Article  CAS  Google Scholar 

  16. Deanfield JE, Shea M, Ribiero P, De Landsheere C, Wilson RA, Horlock P, Selwyn AP Transient ST-segment depression as a marker of myocardial ischemia during daily life. Am J Cardiol 54:1195–1200

    Google Scholar 

  17. Tzivoni D, Benhorin J, Gavish A, Stern S (1985) Holter recording during treadmill testing in assessing myocardial ischemic changes. Am J Cardiol 55:1200–1203

    Article  PubMed  CAS  Google Scholar 

  18. Selwyn AP, Shea M, Deanfield JE, Wilson R, Horlock P, O’Brian HA (1986) Character of transient ischemia in angina pectoris. Am J Cardiol 58:2IB

    Article  Google Scholar 

  19. Pepine CJ (1986) Clinical aspects of silent myocardial ischemia in patients with angina and other forms of coronary heart disease. Am J Med 80 (suppl 4C):25

    Article  PubMed  CAS  Google Scholar 

  20. Weiner DA, Ryan TJ, McCabe CH, Chaitman BR, Sheffield LT, Ferguson JC, Fisher LD, Tristani F (1984) Prognostic importance of a clinical profile and exercise test in medically treated patients with coronary artery disease. J Am Coll Cardiol 3:772

    Article  PubMed  CAS  Google Scholar 

  21. Bonow RO, Kent KM, Rosing DR, Lan KKG, Lakatos E, Borer, JS, Bacharach SL, Green MV, Epstein SE. Exercise-induced ischemia in mildly symptomatic patients with coronary-artery disease and preserved left ventricular function: identification of subgroups at risk of death during medical therapy. N Engl J Med 311:1339

    Google Scholar 

  22. Weiner DA, Ryan TJ, McCabe CH, Fisher LD, Chaitman BR, Sheffield LT, Tristani FE (1985) Value of exercise testing in three-vessel coronary disease (CASS Registry). Circulation 72 (suppl III):III–463 (abst)

    Google Scholar 

  23. Cecchi AC, Dovellini EV, Marchi F, Pucci P, Santoro GM, Fazzini PF (1983) Silent myocardial ischemia during ambulatory electrocardiographic monitoring in patients with effort angina. J Am Cardiol 1:934

    Article  CAS  Google Scholar 

  24. Campbell S, Barry J, Rocco MB, Nabel EG, Mead WK, Rebecca GS, Selwyn AP (1986) Features of the exercise test that reflect the activity of ischemic heart disease out of hospital. Circulation 74:72–80

    Article  PubMed  CAS  Google Scholar 

  25. Tzivoni D, Gavish A, Benhorin J, Karen A, Stern S (1986) Myocardial ischemia during daily activities and stress. Am J Cardiol 58:47B-50B

    Article  PubMed  CAS  Google Scholar 

  26. Stern S, Gavish A, Weisz G, Benhorin J, Tzivoni D (1986) Characteristics of silent and symptomatic myocardial ischemia during everyday activity (abstract). Circulation 74- 11:57

    Google Scholar 

  27. Nademanee K, Intarachot V, Singh PN, Josephson MA, Singh BN (1986) Characteristics and clinical significance of silent myocardial ischemia in unstable angina. Am J Cardiol 58:26B

    Google Scholar 

  28. Gottlieb SO, Weisfeldt M, Ouyang P, Mellits DE, Gerstenblith G (1986) Silent ischemia as marker of unfavourable outcomes in patients with unstable angina. N Engl J Med 314:1214

    Article  PubMed  CAS  Google Scholar 

  29. Gavish A, Tzivoni D, Zin D, Karen A, Benhorin J, Banai S, Stern S (1986) Prognostic significance of ischemic episodes on Holter monitoring during daily activities: 2 years follow-up of 356 patients (abstract). J Am Coll Cardiol 9:240 A

    Google Scholar 

  30. Kannel WB, Abbott RD (1984) Incidence and prognosis of unrecognized myocardial infarction. Based on 26 years follow-up on the Framingham study. In: Rutishauser W, Roskamm H (eds) Silent myocardial ischemia. Berlin: Springer Verlag, pp 131–237

    Google Scholar 

  31. Deanfield JE, Selwyn AP, Cherchia S, Meseri A, Ribiero P, Kriller S, Morgan M (1983) Myocardial ischemia during daily life in patients with stable angina: its relation to symptoms and heart rate changes. Lancet 2:753–8

    Article  PubMed  CAS  Google Scholar 

  32. Tzivoni D, Gavish A, Benhorin J, Banai S, Karen A, Stern S (In press) Day-to-day variability of myocardial ischemic episodes in coronary artery disease. Am J Cardiol

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers

About this chapter

Cite this chapter

Stern, S., Tzivoni, D. (1989). Silent myocardial ischemia on ambulatory Holter monitoring and exercise testing: detection, characteristics and significance. In: Hombach, V., Hilger, H.H., Kennedy, H.L. (eds) Electrocardiography and Cardiac Drug Therapy. Developments in Cardiovascular Medicine, vol 92. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1081-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-1081-2_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6976-2

  • Online ISBN: 978-94-009-1081-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics