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High resolution electrocardiography and magnetocardiography: clinical application

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 92))

Abstract

A high-resolution (HR) surface ECG system is described, suitable for HR real-time (RT) recording and for signal averaging (SA). HR-ECG measurements were done in an electrically shielded room. The signal was amplified with a battery-driven 8-channel preamplifier, digitized with a 12(16)-bit A/D converter and stored in a microcomputer. The overall noise level of the system was below 1 µ Vp-p in the band 0.05–300 Hz. RT- and SA-magnetocardiographic (MCG) measurements were done in a magnetically shielded room using a very sensitive (5 fT/√VHz) DC-SQUID magnetic gradiometer. The output signal was transferred to a minicomputer for analysis. Examples of ECG and MCG recordings of cardiac micropotentials are presented, using both RT- and SA-techniques with special reference to late potentials (LP). The MCG technique was also utilized for localizing the Kent bundle in 6 cases of WPW syndrome. The recovery rate of LP was 37% in patients with recent myocardial infarction (AMI), and 72% in patients with ventricular tachycardia (VT) or ventricular fibrillation (VF). The mean duration of LP in the VT/VF-group was 27 ms, and the mean amplitude 17 µV. The His-Purkinje signal was detected in 60% of cases examined. The RT-ECG proved to be superior to the SA-ECG in detecting intermittent or inconstantly timed signals. Preliminary base-line data of 2 prospective studies are presented (10 patients of which with VT, 10 with recent AMI without VT and 10 healthy controls) using both RT-ECG and SA-ECG, the latter with both time and frequency domain analysis. The initial and terminal QRS notches of the low-gain ECG were most frequent in the VT group, and probably belong to the same category of depolarization abnormalities as LPs.

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References

  1. Siltanen P (1972) The ischaemic heart disease register as a frame for preventive measures. Adv Cardiol 8:225

    Google Scholar 

  2. Siltanen P, Pohjola-Sintonen S, Haapakoski J, Mäkijärvi M, Pajari R (1985) The mortality predictive power of discharge electrocardiogram after first acute myocardial infarction. Am Heart J 109:1231–1237

    Article  PubMed  CAS  Google Scholar 

  3. Oppenheimer BS, Rothschild MA (1917) Electrocardiographic changes associated with myocardial involvement. JAMA 69:429–431

    Google Scholar 

  4. Weinberg HB, Katz LN (1940) Two unusual types of electrocardiograms. Am Heart J 19:519–528

    Article  Google Scholar 

  5. Wilson FN, Johnston FD, Rosenbaum FF, Erlanger H, Kossmann CE, Hecht H, Cotrim M, de Oliveira RM, Scarsi R, Barker PS (1944) The precordial electrocardiogram. Am Heart J 27:19–85

    Article  Google Scholar 

  6. First SR, Bayley RH, Bedford DR (1950) Peri-infarction block: Electrocardiographic abnormality occasionally resembling bundle branch block and local ventricular block of other types. Circulation 2:31–36

    PubMed  CAS  Google Scholar 

  7. Langner PH Jr (1952) Value of high fidelity electrocardiography using cathode ray oscilloscope and expanded time scale. Circulation 5:249–256

    PubMed  Google Scholar 

  8. Alzamora-Castro V, Abugattas R, Rubio C, Bouroncle J, Zapata C, Santa-María E, Paredes D (1953) Parietal focal block: an experimental and electrocardiographic study. Circulation 7:108–115

    PubMed  CAS  Google Scholar 

  9. Cabrera E, Rocha JC, Flores G (1959) El vectorcardiograma de los infartos miocardicos co tras tornos en la conducción intraventricular. Arc Inst Cardiol Méx 29:625–646

    CAS  Google Scholar 

  10. Langner PH Jr, Geselowitz DB (1960) Characteristics of the frequency spectrum in the normal electrocardiogram and in subject following myocardial infarction. Circ Res 8:577–584

    PubMed  Google Scholar 

  11. Zuckermann R (1960) Postexcitation. Z KreislaufT 4:654–658

    Google Scholar 

  12. Raunio H, Anttonen V-M, Meurman L (1965) Terminal QRS forces in posterior myocardial infarction. Ann Med Int Fenn 54:157–168

    PubMed  CAS  Google Scholar 

  13. Anttonen V-M, Raunio H, Krogerus J, Meurman L (1967) The significance of a notch during the terminal 0.04 second of the QRS complex in an electrocardiogram. Ann Med Int Fenn 56:1–7

    PubMed  CAS  Google Scholar 

  14. Raunio H (1969) Significance of a notch during the initial 0.04 sec of the QRS complex in the electrocardiogram. Ann Clin Res l:Suppl 3

    Google Scholar 

  15. Flowers NC, Horan LG, Tolleson WJ, Thomas JR (1969) Circulation 40:927–933

    Google Scholar 

  16. Stopczyk MJ, KopeĆ, J. Źochowski RJ, Pieniak M (1973) Surface recording of electrical heart activity during the P-R segment in man by computer averaging technique. Int Res Com Syst (73–8): 11, 21, 2

    Google Scholar 

  17. Flowers NC, Horan LG (1973) His bundle and bundle branch recordings from the body surface. Circulation 48:Suppl 4:102 (abstr)

    Google Scholar 

  18. Berbari EJ, Lazzara R, Samet P, Scherlag BJ (1973) Noninvasive technique for detection of electrical activity during the PR segment. Circulation 48:1005–1013

    PubMed  CAS  Google Scholar 

  19. Siltanen P, Saarinen M, Katila T, Ahopelto J (1974) Magnetocardiogram in healthy men and women. Proc VIII World Congr Cardiol, Buenos Aires (abstr)

    Google Scholar 

  20. Saarinen M, Karp PJ, Katila TE, Siltanen P (1974) The magnetocardiogram in cardiac disorders. Cardiovasc Res 8:820–834

    Article  PubMed  CAS  Google Scholar 

  21. Farrell DE, Tripp JH, Norgren R (1978) Non-invasive information on the PR segment of the cardiac cycle: an assessment of the clinical potential of the electric and magnetic methods. Proc SPIE 167:173–177

    Google Scholar 

  22. Fontaine G, Frank R, Gallais-Hamonno F, Allali I, Phan-Thuc H, Grosgogeat Y (1978) Electrocardiographic des potentials tardifs du syndrome de post-excitation. Arch Mai Coeur 71:854–864

    CAS  Google Scholar 

  23. A noninvasive method of recording a serial His-Purkinje Study in man. CVP April/May: 16–19 (1980)

    Google Scholar 

  24. Walczak F, Kepski R, Pluciński Z, Piatkowski A (1980) Noninvasive method of HPS system activity measurements without averaging. Preliminary report. Kardiologia Polska 23:625–679

    PubMed  CAS  Google Scholar 

  25. Wajszczuk WL, Palko T, Przybylski J, Stopczyk MJ, Bauld ThJ, Rubenfire M (1981) External recording of sinus node region activity in anomals and in man. In: Hombach V, Hilger HH (eds) Signal averaging technique in clinical cardiology. Stuttgart - New York: F.K. Schattauer Verlag, pp 65–79

    Google Scholar 

  26. Simson MB (1981) Use of signals in the terminal QRS complex to identify patients with ventricular tachycardia after myocardial infarction. Circulation 64:235–242

    Article  PubMed  CAS  Google Scholar 

  27. Hombach V, Kebbel U, Höpp H-W, Winter U-J, Braun V, Deutsch H, Hirche H, Hilger HH (1982) Fortlaufende Registrierung von Mikropotentialen de meschlichen Herzens. Erste Erfahrungen mit einem neuen hochauflösenden EKG-Verstärkersystem. D Med Wchschr 107:1951–1956

    Article  CAS  Google Scholar 

  28. Erné SN, Fenici RR, Hahlbohm H-D, Jaszczuk W, Lehman HD, Masseiii M (1983) High-resolution isofield mapping in magnetocardiography. II Nuovo Cimento 2D: 291- 300

    Article  Google Scholar 

  29. Cain ME, Ambos HD, Witkowski FX, Sobel BE (1984) Fast Fourier Transform analysis of signal-averaged electrocardiograms for identification of patients prone to sustained ventricular tachycardia. Circulation 69:711–720

    Article  PubMed  CAS  Google Scholar 

  30. Erné SN (1985) High resolution magnetocardiography: modeling and sources localization. Med Biol Eng Comp 23:suppl: 1447–1450

    Google Scholar 

  31. Kertes PJ, Glabus M, Murray A, Julian DG, Campbell WF (1984) Delayed ventricular depolarization—correlation with ventricular activation and relevance to ventricular fibrillation in acute myocardial infarction. Eur Heart J 5:974–983

    PubMed  CAS  Google Scholar 

  32. Scherlag BJ, Chesterfield GG, Berbari EJ, Lazzara R (1985) Peri-infarction block (1950)—late potentials (1980): Their relationship, significance and diagnostic implications (Editorial). Am J Cardiol 55:839–841

    Article  PubMed  CAS  Google Scholar 

  33. Kienzle MG, Falcone RA, Josephson ME, Simson MB (1984) High frequency signal amplitude in the early and middle QRS in patients with and without ventricular tachycardia. JACC 3:623 (abstr)

    Google Scholar 

  34. Abboud S, Beihassen B, Miller HI, Sadeh D (1986) High frequency electrocardiography using an advanced method of signal averaging for non-invasive detection of coronary artery disease in patients with normal conventional electrocardiogram. J Electrocardiol 19:371–380

    Article  PubMed  CAS  Google Scholar 

  35. DeCaro M, Volosin KJ, Greenspan AJ (1987) Optimal interval to predict ventricular tachycardia based on frequency analysis of the signal averaged electrocardiogram. JACC 9:suppl:208 (abstr)

    Google Scholar 

  36. Durrer D, VanLier A, Buller J (1964) Epicardial and intramural excitation in chronic myocardial infarction. Am Heart J 68:765–776

    Article  PubMed  CAS  Google Scholar 

  37. Boineau JP, Cox JL (1973) Slow ventricular activation in acute myocardial infarction. A source of reentrant premature ventricular contractions. Circulation 48:702–713

    PubMed  CAS  Google Scholar 

  38. Waldo AL, Kaiser GA (1973) A study of ventricular arrhythmias associated with acute myocardial infarction in the canine heart. Circulation 47:1222–1228

    PubMed  CAS  Google Scholar 

  39. Wellens HJ, Dürrer DR, Lie KI (1976) Observations on mechanisms of ventricular tachycardia in man. Circulation 54:237–244

    PubMed  CAS  Google Scholar 

  40. El-Sherif N, Scherlag BJ, Lazzara R, Hope RR (1977) Reentrant ventricular arrhythmias in late myocardial period. 1. Conduction characteristics in the infarction zone. Circulation 55:686–702

    PubMed  CAS  Google Scholar 

  41. Berbari EJ, Scherlag BJ, Hope RR, Lazzara R (1978) Recording from the body surface of arrhythmogenic ventricular activity during ST segment. Am J Cardiol 41:697–702

    Article  PubMed  CAS  Google Scholar 

  42. Abdollah H, Brugada B, Richards DA, van der Dool A, Green M, Wehr M, Wellens HJJ (1983) Late potentials detected with signal averaged ECG and left ventricular endocardial mapping in patients with ventricular tachycardia. Circulation 68:suppl 3:174 (abstr)

    Google Scholar 

  43. Vassallo JA, Cassidy DM, Simson MB, Marchlinski FE, Buxton AE, Waxman HL, Dresden C, Falcone RA, Josephson ME (1983) Relationship of signal averaged late potentials, endocardial late activity, and origin of ventricular tachycardia. Circulation 68:suppl 3:174 (abstr)

    Google Scholar 

  44. El-Sherif N, Gomes JAC, Restivo M, Mehra R (1985) Late potentials and arrhyth- mogenesis. PACE 8:440–462

    PubMed  CAS  Google Scholar 

  45. Fenici RR, Masseiii M, Erné SN, Hahlbohm HD (1985) Magnetocardiographic mapping of the P-R interval phenomena in an unshielded hospital laboratory. In: Weinberg H, Stroink G, Katila T (eds) Biomagnetism, application and theory. Oxford - New York: Pergamon Press Inc., pp 137–141

    Google Scholar 

  46. Hombach V, Barun V, Höpp H-W, Gil-Sanchez D, Scholl H, Behrenbeck DW, Tauchert M, Hilger HH (1982) The applicability of the signal averaging technique in clinical cardiology. Clin Cardiol 5:107–124

    Article  PubMed  CAS  Google Scholar 

  47. Hombach V, Höpp HV, Kebbel U, Eggeling T, Osterspey A, Hirche H, Hilger HH (1985) Signal averaged and high resolution beat-to-beat ECG technique for recovery of cardiac microvolt potentials. Med Biol Eng Comp 23:suppl: 1451–1452

    Google Scholar 

  48. Flowers NC, Shvartsman V, Sohi GS, Horan LG (1981) Signal averaged versus beat-to- beat recording of surface His-Purkinje potentials. In: Hombach V, Hilger HH (eds): Signal averaging technique in clinical cardiology. Stuttgart: FK Schattauer Verlag, pp 329–349

    Google Scholar 

  49. Stopczyk MJ, Walczak F, Kepski R, Plucinski Z, Peczalski K (1981) The history of non-invasive His-Bundle recording: From averaging to continuous record. In: Hombach V, Hilger HH (eds): Signal averaging technique in clinical cardiology. Stuttgart: FK Schattauer Verlag, pp 283–289

    Google Scholar 

  50. El-Sherif N, Mehra R, Gomes JAC (1983) Appraisal of a low noise electrocardiogram. JACC 1:456–467

    PubMed  CAS  Google Scholar 

  51. Hombach V, Höpp HV, Kebbel U, Treis I, Osterspey A, Eggeling T, Winter U, Hirche H, Hilger HH (1986) Recovery of ventricular late potentials from body surface using the signal averaging and high resolution ECG techniques. Clin Cardiol 9:361–368

    Article  PubMed  CAS  Google Scholar 

  52. Stopczyk MJ (1985) Studies on His-Purkinje activity from the body surface. From digital-time to Spatial-time (4-dimensional, analog-digital) averaging. Med Biol Eng Comp 23:suppl: 1453–1454

    Google Scholar 

  53. Breithardt G, Borggrefe M (1986) Pathophysiological mechanisms and clinical significance of ventricular late potentials. Eur Heart J 7:364–385

    PubMed  CAS  Google Scholar 

  54. Machac J, Weiss A, Winters SL, Barecca P, Gomes JA (1987) A comparative study of frequency- and time-domain analysis of signal averaged ECG’s in ventricular tachycardia. JACC 9:suppl:208 (abstr)

    Google Scholar 

  55. Gomes JA, Stewart D, Winters SL, Barreca P (1987) The signal averaged electrocardiogram in patients with ventricular tachycardia and bundle branch block. JACC 9:suppl:208 (abstr)

    Google Scholar 

  56. Lindsay BD, Ambos HD, Markham J, Casin ME (1987) Identification by frequency- domain analysis of patients with bundle branch block at risk for sustained ventricular tachycardia. JACC 9:suppl:207 (abstr)

    Google Scholar 

  57. Oeff M, von Leitner ER, Schwarz W, Schröder R (1986) Nichtinvasive Registrierung ventrikulärer Spätpotentiale bei Herzgesunden und bei patienten mit intraventrikulären Reitzleitungstörungen. Methode und Ergebnisse der Signalmittelungstechnik. Z Kardiol 7:666–672

    Google Scholar 

  58. Hombach V, Höpp H-V, Braun V, Behrenbeck DW, Tauchert M, Hilger HH (1980) Die Bedeutung von Nachpotentialen innerhalb des ST-Segmentes im Oberflächen-EKG bei Patienten mit koronarer Herzkrankheit. Dtsch med Wschr 105:1457–1462

    Article  PubMed  CAS  Google Scholar 

  59. Breithardt G, Schwarzmaier J, Abendroth RR, Borggrefe M, Seipel L (1981) Prospective study on the incidence of late potentials in post-myocardial infarction patients. Circulation 64:suppl 4:328 (abstr)

    Google Scholar 

  60. Denes P, Santarelli P, Hauser RG, Uretz EF (1983) Quantitative analysis of the high- frequency components of the terminal portion of the body surface QRS in normal subjects and in patients with ventricular tachycardia. Circulation 67:1129–1138

    Article  PubMed  CAS  Google Scholar 

  61. Denes P, Uretz E, Santarelli P (1984) Determinants of arrhythmogenic ventricular activity detected on the body surface QRS in patients with coronary artery disease. Am J Cardiol 53:1519–1523

    Article  PubMed  CAS  Google Scholar 

  62. Denniss AR, Richards DA, Cody DV, Russell PA, Young AA, Cooper MJ, Ross DL, Uther JB (1986) Prognostic significance of ventricular tachycardia and fibrillation induced at programmed stimulation and delayed potentials detected on the signal-averaged electrocardiograms of survivors of acute myocardial infarction. Circulation 74:731–745

    Article  PubMed  CAS  Google Scholar 

  63. Kuchar DL, Thorburn CW, Sammel NL (1986) Late potentials detected after myocardial infarction: natural history and prognostic significance. Circulation 74:1280–1289

    Article  PubMed  CAS  Google Scholar 

  64. Osterspey A, Höpp H-W, Hombach V, Deutsch H-J, Winter U, Behrenbeck DW, Tauchert M, Hilger HH (1983) Diagnostic and prognostic significance of ventricular late potentials in patients with coronary heart disease. In: Steinbach K (ed.) Cardiac pacing. Proceedings of the 7th World Symposium on Cardiac Pacing, Vienna 1983. Darmstatt: Steinkopff, pp 283–290

    Google Scholar 

  65. Denniss AR, Ross DL, Richards DA, Uther JB (1985) Changes in incidence of delayed potentials after myocardial infarction. Circulation 72:suppl 3:164 (abstr)

    Google Scholar 

  66. Lewis SJ, Lander OT, Taylor PA, Chamberlain DA, Vincent R (1987) The natural history of ventricular late potential activity in acute myocardial infarction. JACC 9:suppl:151 (abstr)

    Google Scholar 

  67. Panidis J, Morganroth J (1983) Sudden death in hospitalized patients: cardiac rhythm disturbances detected by ambulatory electrocardiographic monitoirng. JACC 2:798–805

    PubMed  CAS  Google Scholar 

  68. Pratt GM, Francis MJ, Luck JC, Wyndham CR, Miller RR, Quinones MA (1983) Analysis of ambulatory electrocardiograms in 15 patients during spontaneous ventricular fibrillation with special reference to preceding arrhythmic events. JACC 2:789–797

    PubMed  CAS  Google Scholar 

  69. Höpp H-W, Hombach V, Deutsch H-H, Osterspey A, Winter U, Hilger HH (1983) Assessment of ventricular vulnerability by Holter ECG, programmed ventricular stimulation and recording of ventricular late potentials. In: Steinbach K (ed.): Cardiac pacing, proceedings of the 7th World Symposium on Cardiac Pacing, Vienna 1983. Darmstadt: Steinkopff, pp 283–290

    Google Scholar 

  70. Haerten K, Borggrefe M, Breithardt G (1983) Repetitive ventricular response and late potentials in patients early after myocardial infarction. Circulation 68:suppl 3:174 (abstr)

    Google Scholar 

  71. Breithardt G, Borggrefe M, Karbenn U, Abendroth R-R, Seipel L (1983) Ventricular vulnerability and presence of late potentials in patients without documented ventricular tachycardia. PACE 6:suppl:108 (abstr)

    Google Scholar 

  72. Saarinen M, Siltanen P, Karp PJ, Katila T (1978) The normal magnetocardiogram. I. Morphology. Ann Clin Res 10:suppl 21

    Google Scholar 

  73. Siltanen P (1987) Magnetocardiography. In: Macfarlane PW, Lawrie TDW (eds) Elec- trocardiology, Ch 37. London: Bailliére & Tindall

    Google Scholar 

  74. Katila T, Maniewski R, Mäkijärvi M, Nenonen J, Siltanen P (1987) On the accuracy of source localization in cardiac measurements. Phys Med Biol 32:125–131

    Article  PubMed  CAS  Google Scholar 

  75. Docker MF (1971) Computing in the study of the fetal electrocardiogram. In: Computer for analysis and control in medical and biological research. IEEE Conference Publication 79:17

    Google Scholar 

  76. Kariniemi V, Ahopelto J, Karp PJ, Katila TE (1974) The fetal magnetocardiogram. J Perinat Med 2:214–216

    Article  PubMed  CAS  Google Scholar 

  77. Leoni R, Romani GL (1982) Computer simulation of magnetic field patterns from the human cardiac conduction system. II Nuovo Cimento lD:737–750

    Article  Google Scholar 

  78. Berbari EJ, Collins SM, Salu, Y, Arzbaecher R (1983) Orthogonal surface lead recordings of His-Purkinje activity: comparison of actual and simulated waveforms. IEEE Trans Biomed Eng BME-30:160–167

    Article  CAS  Google Scholar 

  79. Denniss AR, Ross DL, Uther JB (1986) Reproducibility of measurements of ventricular activation time using the signal-averaged Frank vector-cardiogram. Am J Cardiol 57:156–160

    Article  PubMed  CAS  Google Scholar 

  80. Kanowsky MS, Falcone RA, Dresden CA, Josephson ME, Simson MB (1984) Identification of patients with ventricular tachycardia after myocardial infarction: signal- averaged electrocardiogram, Holter monitoring and cardiac catheterization. Circulation 70:264–270

    Article  Google Scholar 

  81. Cain ME, Ambos HD, Markham J, Fisher A, Sobel BE (1985) Quantification of differences in frequency content of signal-averaged electrocardiograms in patients with compared to those without sustained ventricular tachycardia. Am J Cardiol 55:1500–1505

    Article  PubMed  CAS  Google Scholar 

  82. Haberl R, Hengstenberg E, Pulter R, Steinbeck G (1986) Frequenzanalyse des Ein- zelschlag-Elektrokardiogrammes zur Diagnostik von Kammer-tachykardien. Z Kardiol 75:659–665

    PubMed  CAS  Google Scholar 

  83. Pyörälä K, Raunio H, Kentala E (1975) Occurrence and regression of initial and terminal notching of the QRS complex in the electrocardiograms of patients with acute myocardial infarction. Ann Clin Res 7:426–432

    PubMed  Google Scholar 

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Siltanen, P. et al. (1989). High resolution electrocardiography and magnetocardiography: clinical application. In: Hombach, V., Hilger, H.H., Kennedy, H.L. (eds) Electrocardiography and Cardiac Drug Therapy. Developments in Cardiovascular Medicine, vol 92. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1081-2_20

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  • DOI: https://doi.org/10.1007/978-94-009-1081-2_20

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