Lens Hexitols and Cataract Formation During Lactation in a Woman Heterozygote for Galactosaemia
The occurrence of cataracts in a healthy lactating woman, heterozygous for UDP glucose-hexose-l-phosphate uridyltransferase (GALT; EC 18.104.22.168) deficiency (McKusick 23040), may suggest a possible link to the enzymatic defect of galactose metabolism. As studies in rats (Ng et al., 1987) showed that prolactin accelerates galactose-induced cataractogenesis, i.e. aldose reductase mediated accumulation of galactitol in the lenses, our purpose was to determine the hexitol contents of the patient’s lens tissue.
KeywordsCataract Formation Lens Protein Cataractous Lens Galactose Metabolism GALT Activity
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