Copper-Containing Amine Oxidases

  • Alessandro Finazzi-Agro’

Abstract

Amine oxidases catalyze the reaction
$$ R - C{H_2}NH_3^{+} \quad + \quad {O_2}\quad + \quad {H_2}O \to R - CHO\quad + \quad NH_4^{+} \quad + \quad {H_2}{O_2} $$
where R can be either aromatic or aliphatic. The copper-containing amine oxidases (Cu-AOs) oxidize only primary amines at variance with FAD-containing amine oxidases (eg. mitochondrial MAO). Several trivial names have been used for Cu-AOs, such as benzylamine oxidase, histaminase, diamine oxidase, lysyloxidase, spermine oxidase etc. on the basis of their substrate specificity. Thev are widespread in nature among eukaryotes though a prokaryotic Cu-AO has been recently described (van Iersel etal., 1986).

Keywords

Amine Oxidase Diamine Oxidase Pyridoxal Phosphate Redox Component Diamine Oxidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Alessandro Finazzi-Agro’
    • 1
  1. 1.Dipartimento di Medicina Sperimentale e Scienze BiochimicheUniversità degli Stuai di Roma “Tor Vergata”RomaItaly

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