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The hemodynamics of borderline hypertension

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 98))

Abstract

The hemodynamic history of borderline hypertension is rich with the contributions of numerous investigators over the past five decades. This is a particularly propitious time to review the literature, since it comes near the end of a long transition period from basic descriptive hemodynamic investigations of cardiac output, mean arterial pressure, and calculated peripheral resistance to studies of more subtle abnormalities in cardiovascular compliance, regional hemodynamic regulation, receptor specific hemodynamic events, and the cellular basis of hemodynamic derangements. In the following pages these considerable accomplishments are summarized and an attempt is made to synthesize the information into a unifying concept on the hemodynamic pathogenesis and progression of borderline hypertension.

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References

  1. Kanell WB, Sorlie P and Gordon T (1979): Labile hypertension: A faulty concept? The Framingham Study. Circulation 61: 1183–1187.

    Google Scholar 

  2. Horan MJ, Kennedy HL, Padgett NE (1981): Do borderline hypertensive patients have labile blood pressure? Ann Int Med 94(Part 1): 466–468.

    PubMed  CAS  Google Scholar 

  3. Pickering TG, Harshfield GA, Blank S, James GD, Laragh JH, Clark L, Denby L, Pregibon D (1986): Behavioral determinants of 24-hour blood pressure patterns in borderline hypertension. J Cardiovasc Pharmacol 8(Suppl 5): S89–S92.

    Article  PubMed  Google Scholar 

  4. Hines EA (1951): The significance of hyperreactivity in the natural history of essential hypertension, in: A Symposium on Essential Hypertension: An Epidemiologic Approach to the Elucidation of Its Natural History in Man, pp 256–263. Boston: Wright & Potter Printing Co.

    Google Scholar 

  5. Wood DL, Sheps SG, Elveback LR, Schirger A (1984): Cold pressor test as a predictor of hypertension. Hypertension 6: 301–306.

    PubMed  CAS  Google Scholar 

  6. Dlin RA, Hanne N, Silverberg DS, Bar-Or O (1983): Follow-up of normotensive men with exaggerated blood pressure response to exercise. Am Heart J 106: 316–320.

    Article  PubMed  CAS  Google Scholar 

  7. Falkner B, Kushner H, Onesti G, Angelakos ET (1981): Cardiovascular characteristics in adolescents who develop essential hypertension. Hypertension 3: 521–527.

    PubMed  CAS  Google Scholar 

  8. Payen DM, Safar ME, Levenson JA, Totomokouo JA, Weiss YA (1982): Prospective study of predictive factors determining borderline hypertensive individuals who develop sustained hypertension: Prognostic value of increased diastolic orthostatic blood pressure tilt-test response and subsequent weight gain. Am Heart J 103: 379–383.

    Article  PubMed  CAS  Google Scholar 

  9. Nestel PJ (1969): Blood pressure and catecholamine excretion after mental stress in labile hypertension. Lancet 1: 692–694.

    Article  PubMed  CAS  Google Scholar 

  10. Falkner B, Onesti G, Angelakos ET, Fernandes M, Langman C (1979): Cardiovascular response to mental stress in normal adolescents with hypertensive parents. Hemodynamics and mental stress in adolescents. Hypertension 1: 23–30.

    PubMed  CAS  Google Scholar 

  11. Esler MD, Nestel PJ (1973): Sympathetic responsiveness to head-up tilt in essential hypertension. Clin Sci 44: 213–226.

    PubMed  CAS  Google Scholar 

  12. Hull DH, Wolthuis RA, Cortese T, Longo MR Jr, Triebwasser JH (1977): Borderline hypertension versus normotension: Differential response to orthostatic stress. Am Heart J 94: 414–420.

    Article  PubMed  CAS  Google Scholar 

  13. Frohlich ED, Tarazi RC, Ulrych M, Dustan HP, Page IH (1967): Tilt test for investigating a neural component in hypertension. Circulation 36: 387–393.

    PubMed  CAS  Google Scholar 

  14. Eide I, Campese V, Stein D, Eide K, DeQuattro V (1978): Clinical assessment of sympathetic tone: Orthostatic blood pressure responses in borderline primary hypertension. Clin Exper Hypertension 1(1): 51–65.

    Article  CAS  Google Scholar 

  15. Folle LE, Dighiero J, Sadi I, Pommerenck C, Elena R (1970): Hemodynamic response to exercise after beta-adrenergic blockade in normal and labile hypertensive patients. Cardiology 55: 105–113.

    Article  PubMed  CAS  Google Scholar 

  16. Kramer AA, Shkhvatsabaya LV, Eventov AZ, Pershakova LP (1972): Peculiarities of the central and renal hemodynamics in patients with hypertensive disease at its early stage. Kardiologiya 12: 31–40.

    PubMed  CAS  Google Scholar 

  17. Thacker EA (1940): A comparative study of normal and abnormal blood pressures among university students, including the cold pressor test. Am Heart J 20: 89–97.

    Article  Google Scholar 

  18. Shapiro AP (1961): An experimental study of comparative responses of blood pressure to different noxious stimuli. J Chronic Dis 13: 293–311.

    Article  Google Scholar 

  19. Thomas CB, Stanley JA, Kendrick MA (1961): Observations on some possible precursors of essential hypertension and coronary artery disease, VII: The subjective reaction to the cold pressor test as expressed in the verbal response. J Chronic Dis 14: 355–365.

    Article  PubMed  CAS  Google Scholar 

  20. Cuddy RP, Smulyan H, Keighley JF, Markason CR, Eich RH (1966): Hemodynamic and catecholamine changes during a standard cold pressor test. Am Heart J 71: 446–465.

    Article  PubMed  CAS  Google Scholar 

  21. Eich RH, Jacobsen EC (1967): Vascular reactivity in medical students followed for 10 years. J Chronic Dis 20: 583–592.

    Article  PubMed  CAS  Google Scholar 

  22. Konig K, Reindell H, Steim H, et al. (1959): Beitrag zur hamodynamik hypertoner regu-lationsstorungen [Contribution to the hemodynamics of the hypertone regulation]. Z Kreislaufforsch 48: 923–939.

    Google Scholar 

  23. Maidorn K, Mellevovicz H (1963): Arterial blood pressure during an ergometric lead. Z Kreislaufforsch 52: 53–63.

    Google Scholar 

  24. Sannerstedt R (1966): Hemodynamic response to exercise in patients with arterial hypertension. Acta Med Suppl 458: 1–83.

    CAS  Google Scholar 

  25. Levy AM, Tabakin BS, Hanson JS (1967): Hemodynamic responses to graded treadmill exercise in young untreated labile hypertensive patients. Circulation 35: 1063–1072.

    PubMed  CAS  Google Scholar 

  26. Conway J, Julius S, Amery A (1968): Effect of blood pressure level on the hemodynamic response to exercise. Hypertension 16: 79–85.

    Google Scholar 

  27. Julius S, Conway J (1968): Hemodynamic studies in patients with borderline blood pressure elevation. Circulation 38: 282–288.

    PubMed  CAS  Google Scholar 

  28. Sannerstedt R (1969): Hemodynamic findings at rest and during exercise in mild arterial hypertension. Am J Med Sci 258: 70–79.

    Article  PubMed  CAS  Google Scholar 

  29. Sannerstedt R, Julius S (1972): Systemic haemodynamics in borderline arterial hypertension: Responses to static exercise before and under the influence of propranolol. Cardiovasc Res 6: 318–403.

    Article  Google Scholar 

  30. DeCarvalho JGR, Messerli FH, Frohlich ED (1979): Mitral valve prolapse and borderline hypertension. Hypertension 1(5): 518–522.

    PubMed  CAS  Google Scholar 

  31. Widimsky VJ, Fejfarova HM, Fejfar Z, Dejdar R, Exnerova M, Pirk F (1958): Der jugendliche Hochdruk [Juvenile hypertension]. Arch Kreislaufforsch 28: 100–124.

    Article  PubMed  CAS  Google Scholar 

  32. Brod J (1963): Haemodynamic basis of acute pressor reactions and hypertension. Br Heart J 25: 227–245.

    Article  PubMed  CAS  Google Scholar 

  33. Sannerstedt R, Julius S, Conway J (1970): Hemodynamic responses to tilt and beta-adrenergic blockade in young patients with borderline hypertension. Circulation 42: 1057–1064.

    PubMed  CAS  Google Scholar 

  34. Molzahn M, Dissmann TH, Halim S, Lohmann FW, Oelkers W (1972): Orthostatic changes of haemodynamics, renal function, plasma catecholamines and plasma renin concentration in normal hypertensive man. Clin Sci 422: 209–222.

    Google Scholar 

  35. Julius S, Pascual AV, Sannerstedt R, Mitchell C (1971): Relationship between cardiac output and peripheral resistance in borderline hypertension. Circulation 43: 382–390.

    PubMed  CAS  Google Scholar 

  36. Julius S (1987): Hemodynamic, pharmacologic and epidemiologic evidence for behavioral factors in human hypertension, in: Julius S and Bassett DR (eds), Handbook of Hypertension, Vol 9: Behavioral Factors in Hypertension, Ch 4, pp 59–74. Amsterdam: Elsevier Science Publishers.

    Google Scholar 

  37. Esler M, Julius S, Zweifler A, Randall O, Harburg E, Gardiner H, DeQuattro V (1977): Mild high-renin essential hypertension. Neurogenic human hypertension? New Engl J Med 296: 405–411.

    Article  PubMed  CAS  Google Scholar 

  38. Schneider RH, Egan BM, Johnson EH, Drobny H, Julius S (1986): Anger and anxiety in borderline hypertension. Psychosomat Med 48(3/4): 242–248.

    CAS  Google Scholar 

  39. Ambrosioni E, Costa FV, Borghi C, Montebugnoli L, Giordani MF, Magnani B (1982): Effects of moderate salt restriction on intralymphocytic sodium and pressor response to stress in borderline hypertension. Hypertension 4: 789–794.

    PubMed  CAS  Google Scholar 

  40. Borghi C, Costa FV, Boschi S, Mussi A, Ambrosioni E (1986): Predictors of stable hypertension in young borderline subjects: A five-year follow-up study. J Cardiovasc Pharm 8(suppl 5):S138–S141.

    Article  Google Scholar 

  41. Cowley AW, Liard JF, Guyton AC (1973): Role of the baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ Res 32: 564.

    PubMed  Google Scholar 

  42. Talman WT, Alonso DR, Reis DJ (1980): Impairment of baroreceptor function and chronic lability of arterial pressure produced by lesions of A2 catecholamine neurons of rat brain: Failure to evolve into hypertension, in: Sleight P (ed), Baroreceptors and hypertension, pp 448 ff. Oxford: Oxford University Press.

    Google Scholar 

  43. Watson RDS, Stallard TJ, Flinn RM, Littler WA (1980): Factors determining direct arterial pressure and its variability in hypertensive man. Hypertension 2: 333–341.

    PubMed  CAS  Google Scholar 

  44. Conway J, Boon N, Davies C, Vann Jones J, Sleight P (1984): Neural and humoral mechanisms involved in blood pressure variability. J Hypertension 2: 203–208.

    Google Scholar 

  45. Takeshita A, Tanaka N, Kuroiwa NM, et al. (1975): Reduced baroreceptor sensitivity in borderline hypertension. Circulation 51: 738–742.

    PubMed  CAS  Google Scholar 

  46. Skrabal F, Auböck J, Hörtnagl H, Braunsteiner H (1980): Effect of moderate salt restriction and high potassium intake on pressor hormones, response to noradrenaline and baroreceptor function in man. Clin Sci 59: 157s–160s.

    PubMed  CAS  Google Scholar 

  47. Ferrario CM, Tramposch A, Kawano Y, Brosnihan KB (1987): Sodium balance and the reflex regulation of baroreceptor function. Circulation 75(suppl I): I-141–148.

    CAS  Google Scholar 

  48. Takeshita A, Tanaka S, Nakamura M (1978): Effects of propranolol on baroreflex sensitivity in borderline hypertension. Cardiovasc Res 12: 148–151.

    Article  PubMed  CAS  Google Scholar 

  49. Ibsen H, Egan B, Julius S (1983): Baroreflex sensitivity during converting enzyme inhibition with Enalapril (MK—421) in normal man. J Hypertension 1(Suppl 2): 222–224.

    CAS  Google Scholar 

  50. Julius S (1976): Neurogenic component in borderline hypertension, in: Julius S and Esler M (eds), The Nervous System in Arterial Hypertension, pp 301–330. Springfield, Ill.: Charles C. Thomas.

    Google Scholar 

  51. Eckberg DL (1979): Carotid baroreflex function in young men with borderline blood pressure elevation. Circulation 59: 632–636.

    PubMed  CAS  Google Scholar 

  52. Randall OS, Esler MD, Bulloch GF, Maisel AS, Ellis CN, Zweifler AJ, Julius S (1976): Relationship of age and blood pressure to baroreflex sensitivity and arterial compliance in man. Clin Sci Mol Med 51: 357s–360s.

    Google Scholar 

  53. Wezler K, Boger A (1939): Die dynamik des arteriellen systems: Der arterielle blutdruck und seine komponenten [The dynamics of the arterial system: Arterial pressure and its components]. Ergeb Physiol 41: 292–606.

    Google Scholar 

  54. Goldring W, Chasis H (1944): Hypertension and Hypertensive Disease. New York, N.Y.: The Commonwealth Fund.

    Google Scholar 

  55. Werko L, Lagerlof B (1949): Studies on the circulation in man (IV). Cardiac output and blood pressure in the right auricle, right ventricle and pulmonary artery in patients with hypertensive cardiovascular disease. Acta Med Scand 133: 427–436.

    Article  PubMed  CAS  Google Scholar 

  56. Eich RH, Peters RJ, Cuddy RP, Smulyan H, Lyons RH (1962): The hemodynamics in labile hypertension. Am Heart J 63: 188–195.

    Article  PubMed  CAS  Google Scholar 

  57. Finkielman S, Worcel M, Agrest A (1965): Hemodynamic patterns in essential hypertension. Circulation 31: 356–368.

    PubMed  CAS  Google Scholar 

  58. Safar ME, Weiss YA, Levenson JA, et al. (1973): Hemodynamic study of 85 patients with borderline hypertension. Am J Cardiol 31: 315–319.

    Article  PubMed  CAS  Google Scholar 

  59. Safar M, Milliez P (1972): Hemodynamic findings in human arterial hypertension. Rev Eur Etud Clin Biol 27: 147–154.

    Google Scholar 

  60. Tourniaire A, Blum J, Tartulier M, Lestaevel M (1972): Hypertension arterielle labile — varietes hemodynamiques. Nouv Presse Med 1: 255–256.

    PubMed  CAS  Google Scholar 

  61. Safar ME, Hornych AF, Levenson JA, Simon ACh, London GM, Bariety JL, Milliez PL (1981): Central hemodynamics and plasma prostaglandin E2 in borderline and sustained essential hypertensive patients before and after indomethacin. Clin Sci 61: 323s–325s.

    PubMed  CAS  Google Scholar 

  62. Safar ME, Weiss YA, London GM, Frachowiak RF, Milliez PL (1974): Cardiopulmonary blood volume in borderline hypertension. Clin Sci Mol Med 47: 153–164.

    PubMed  CAS  Google Scholar 

  63. Dissmann T, Gotzen R, Molzahn M, Lohmann FW, Schwab M (1970): Blood circulation mechanics in essential and renovascular hypertension. Arch Kreislaufforsch 63: 226–256.

    Article  PubMed  CAS  Google Scholar 

  64. Molzahn M, Dissmann TH, Gotzen R, Lohmann FW (1971): The effects of acute and chronic diminution of cardiac output on blood pressure in early hypertension. Hemodynamic alterations after beta-receptor blockade. Klin Wochenschr 49: 476–484.

    Article  PubMed  CAS  Google Scholar 

  65. Juchama Von R, Wertz U (1969): Central hemodynamics of the hyperkinetic syndrome under blockade with beta receptors. Muench Med Wochenschr 111: 2567–2571.

    Google Scholar 

  66. Kuramoto K, Murata K, Yazaki Y, Ikeda M, Nakao K (1968): Hemodynamics in the juvenile hypertension with special reference to the response to propranolol. Jap Circ J 32: 981–987.

    Article  PubMed  CAS  Google Scholar 

  67. Miura Y,, Kobayashi K, Sakuma H, Tomioka H, Acachi M, Yoshinaga K (1978): Plasma noradrenaline concentrations and haemodynamics in the early stage of essential hypertension. Clin Sci Mol Med 55: 69s–71s.

    CAS  Google Scholar 

  68. Lund-Johansen P (1967): Hemodynamics in early essential hypertension. Acta Med Scand suppl 482: 1–100.

    Google Scholar 

  69. Lund-Johansen P (1986): Hemodynamic patterns in the natural history of borderline hypertension. J Cardiovasc Pharm 8(Suppl 5): S8–14.

    Article  Google Scholar 

  70. Bello CT, Sevy RW, Harakal C (1965): Varying hemodynamic patterns in essential hypertension. Am J Med Sci 250: 24–35.

    Article  PubMed  CAS  Google Scholar 

  71. Frohlich ED, Tarazi RC, Dustan HP (1969): Re-examination of the hemodynamics of hypertension. Am J Med Sci 257: 9–23.

    Article  PubMed  CAS  Google Scholar 

  72. Frohlich ED, Kozul VJ, Tarazi RC, Dustan HP (1970): Physiological comparison of labile and essential hypertension. Circ Res 46(Suppl 1): 55–69.

    Google Scholar 

  73. Julius S, Pascual AV, London R (1971): Role of parasympathetic inhibition in the hyperkinetic type of borderline hypertension. Circulation 44: 413–418.

    PubMed  CAS  Google Scholar 

  74. Messerli FH, DeCarvalho JGR, Christie B, Frohlich ED (1978): Systemic and regional hemodynamics in low, normal and high cardiac output borderline hypertension. Circulation 58: 441–448.

    PubMed  CAS  Google Scholar 

  75. Messerli FH, Frohlich ED, Suarez DH, Reisin E, Dreslinski GR, Dunn FG, Cole FE (1981): Borderline hypertension: Relationship between age, hemodynamics and circulating catecholamines. Circulation 64(4): 760–764.

    Article  PubMed  CAS  Google Scholar 

  76. Sullivan JM, Prewitt RL, Josephs JA (1983): Attenuation of the microcirculation in young patients with high-output borderline hypertension. Hypertension 5: 844–851.

    PubMed  CAS  Google Scholar 

  77. Eich RH, Cuddy RP, Smulyan H (1966): Hemodynamics in labile hypertension: A follow-up study. Circulation 34: 299–307.

    PubMed  CAS  Google Scholar 

  78. Eliasch H, Varnauskas E, Werko L (1971): Minutvolym och perifert motstand vid hypertoni-enlongitudinell studie, in: Hansson L (ed): Hypertoni och arteriosklerosfragor, pp 17–19. Goteborg, Sweden: Lindgren.

    Google Scholar 

  79. Weiss YA, Safar ME, London GM (1978): Repeat hemodynamics determinations in borderline hypertension. Am J Med 64: 382–387.

    Article  PubMed  CAS  Google Scholar 

  80. Julius S, Quadir H, Gajendragadkar S (1979): Hyperkinetic stage: A precursor of hypertension? A longitudinal study of borderline hypertension, in: Gross F, Strasser T (eds): Mild hypertension: Natural history and management, pp 116–126. Bath, UK: Pittman Medical.

    Google Scholar 

  81. Lund-Johansen P (1979): Hemodynamic observations in mild hypertension, in: Gross F, Strasser T (eds): Mild hypertension: Natural history and management, pp 19–34. Bath, UK: Pittman Medical.

    Google Scholar 

  82. Andersson OK, Sannderstedt T, Beckman M (1983): Essential hypertension: Implications for pathogenesis from repeated hemodynamic investigations in young men with elevated blood pressure. J Hypertension 1(Suppl 2): 91–93.

    CAS  Google Scholar 

  83. Ibrahim MM, Tarazi RC, Dustan HP, Bravo EL (1973): Cardioadrenergic factor in essential hypertension: Clinical recognition. Circulation 48(suppl 4): 180.

    Google Scholar 

  84. Ellis CN, Julius S (1973): Role of central blood volume in hyperkinetic borderline hypertension. Br Heart J 35: 450–455.

    Article  PubMed  CAS  Google Scholar 

  85. Esler M, Julius S, Randall OS, Ellis CN, Kashima T (1975): Relation of renin status to neurogenic vascular resistance in borderline hypertension. Am J Cardiol 36: 708–715.

    Article  PubMed  CAS  Google Scholar 

  86. Borst JGG, Borst-de Geus A (1963): Hypertension explained by Starling’s theory of circulatory homeostasis. Lancet 1963/1: 677–682.

    Article  Google Scholar 

  87. Coleman TG, Granger HJ, Guyton AC (1971): Whole-body circulatory autoregulation and hypertension. Circ Res 28–29(suppl 2): 76–86.

    Google Scholar 

  88. Guyton AC, Coleman TG (1967): Long-term regulation of the circulation: Interrelationships with body fluid volumes, in: Reeve EG, Guyton AC (eds): Physical Bases of Circulatory Transport: Regulation and Exchange, p 179. W.B. Saunders Co.

    Google Scholar 

  89. Ledingham, JM (1971): The etiology of hypertension. Practitioner 202: 5–19.

    Google Scholar 

  90. Kuramoto K, Murata K, Yazaki Y, Ikeda M, Nakao K (1968): Hemodynamics in the juvenile hypertension with special reference to the response to propranolol. Jap Circ J 32: 981–987.

    Article  PubMed  CAS  Google Scholar 

  91. Birkenhager WH, Van Es LS, Houwing A, Lamers HJ, Mulder AH (1968): Studies on the lability of hypertension in man. Clin Sci 35: 445–456.

    PubMed  CAS  Google Scholar 

  92. Julius S, Pascual AV, Reilly K, London R (1971): Abnormalities of plasma volume in borderline hypertension. Arch Intern Med 127: 116–119.

    Article  PubMed  CAS  Google Scholar 

  93. Dissman TH, Gotren R, Muller B, Neuber K (1967): Plasma and red blood cell volume in incipient essential hypertension. Verh Dtsch Ges Inn Med 73: 604–607.

    Google Scholar 

  94. Takeshita A, Mark AL (1979): Decreased venous distensibility in borderline hypertension. Hypertension 1(3): 202–206.

    PubMed  CAS  Google Scholar 

  95. Julius S, Esler M (1975): Autonomic nervous cardiovascular regulation in borderline hypertension. Am J Cardiol 36: 685–696.

    Article  PubMed  CAS  Google Scholar 

  96. Weder AB, Fitzpatrick MA, Torretti BA, Hinderliter AL, Egan BM, Julius S (1987): Red blood Li+-Na+ countertransport, Na+-K+ cotransport, and the hemodynamics of hypertension. Hypertension 9: 459–466.

    PubMed  CAS  Google Scholar 

  97. Robertson D, Shand DG, Hollifield JW, Nies AS, Frolich JC, Oates JA (1979): Alterations in the responses of the sympathetic nervous system and renin in borderline hypertension. Hypertension 1(2): 118–124.

    PubMed  CAS  Google Scholar 

  98. Fitzpatrick MA, Hinderliter AL, Egan BM, Julius S (1986): Decreased venous distensibility and reduced renin responsiveness in hypertension. Hypertension 8(suppl II): 11-36–43.

    Google Scholar 

  99. Egan B, Fitzpatrick MA, Julius S (1987): The heart and the regulation of renin. Circulation 75(suppl I): I-130–133.

    CAS  Google Scholar 

  100. Kiowski W, Julius S (1978): Renin response to stimulation of cardiopulmonary mechanoreceptors in man. J Clin Invest 62: 656–663.

    Article  PubMed  CAS  Google Scholar 

  101. Egan B, Julius S, Cottier C, Osterziel KJ, Ibsen H (1983): The role of cardiovascular receptors on the neural regulation of renin release in normal man. Hypertension 5: 779–786.

    PubMed  CAS  Google Scholar 

  102. Julius S (1976): Abnormalities of autonomic nervous control in borderline hypertension. Schweiz med Wschr 106: 1698–1705.

    PubMed  CAS  Google Scholar 

  103. Tarazi RC, Ibrahim MM, Dustan HP, Ferrarlo C (1974): Cardiac factors in hypertension. Circ Res 34–35(suppl I): I-213–221.

    Google Scholar 

  104. Ferguson JJ, Julius S, Randall OS (1984): Stroke volume-pulse pressure relationships in borderline hypertension: A possible indicator of decreased arterial compliance. J Hypertension 2(Suppl 3): 397–399.

    Google Scholar 

  105. Ventura H, Messerli FH, Oigman W, Suarez DH, Dreslinski GR, Dunn FG, Reisin E, Frohlich ED (1984): Impaired systemic arterial compliance in borderline hypertension. Am Heart J 108: 132–136.

    Article  PubMed  CAS  Google Scholar 

  106. Simon A, Levinson J, Bouthier J, Maarek B (1987): Hemodynamic basis of early modifications of the large arteries in borderline hypertension. J Hypertension 5: 179–184.

    Article  CAS  Google Scholar 

  107. Tarazi RC, Magrini F, Dustan HP (1975): The role of aortic distensibility of hypertension, in: Miller P, Safar MD (eds), International Symposium on Hypertension, Monaco, p. 133. Boehringer Ingelheim.

    Google Scholar 

  108. Julius S, Randall OS, Esler MD, Kashima T, Ellis C, Bennett J (1975): Altered cardiac responsiveness and regulation in the normal cardiac output type of borderline hypertension. Circ Res 36–37(suppl I): I-199–207.

    Google Scholar 

  109. Sullivan JM, Ratts TE, Taylor JC, Kraus HD, Barton BR, Patrick DR, Reed SW (1980): Hemodynamic effects of dietary sodium in man: A preliminary report. Hypertension 2: 506–514.

    PubMed  CAS  Google Scholar 

  110. Sullivan JM, Prewitt RL, Ratts TE, Josephs JA, Connor MJ (1987): Hemodynamic characteristics of sodium-sensitive human subjects. Hypertension 9: 398–406.

    PubMed  CAS  Google Scholar 

  111. Campese VM, Romoff MS, Levitan D, Saglikes Y, Freidler R, Massry S (1982): Abnormal relationship between sodium intake and sympathetic nervous system activity in salt-sensitive patients with essential hypertension. Kidney Int 21: 371–378.

    Article  PubMed  CAS  Google Scholar 

  112. Kirkendall WM, Connor WE, Abboud FM, Rastogi SP, Anderson TA, Fry M (1972): Effect of dietary sodium on the blood pressure of normotensive man, in: Genest J (ed), Internationall ymposium on Renin-Angiotensin-Aldosterone-Sodium in Hypertension, pp 360–373. Springer-Verlag.

    Google Scholar 

  113. Redgrave J, Rabinowe S, Hollenberg W, et al. (1985): Correction of abnormal renal blood flow response to angiotensin II by converting enzyme inhibition in essential hypertensives. J Clin Invest 75: 1285.

    Article  PubMed  CAS  Google Scholar 

  114. Fujita T, Henry WL, Bartter FC, Lake CR, Delea CS (1980): Factors influencing blood pressure in salt-sensitive patients with hypertension. Am J Med 69: 334–344.

    Article  PubMed  CAS  Google Scholar 

  115. Takeshita A, Mark AL (1978): Neurogenic contribution to hindquarter vasoconstriction during high sodium intake in Dahl strain of genetically hypertensive rats. Circ Res 43(suppl I): I-86–91.

    Google Scholar 

  116. Mark AL, Lawton WJ, Abboud TM, Fitz AE, Connor WE, Heistad DD (1975): Effects of high and low sodium intake on arterial pressure and forearm vascular resistance in borderline hypertension. Circ Res 36–37(suppl I): I-194–198.

    Google Scholar 

  117. Takeshita A, Imaizumi T, Ashihara T, Nakamura M (1982): Characteristics of responses to salt loading and deprivation in hypertensive subjects. Circ Res 51: 457–464.

    PubMed  CAS  Google Scholar 

  118. Skrabal F, Herholz H, Neumayr M, Hamberger L, Ledochocowski M, Sporer H, Hortnagl H, Schwartz S, Schonitzer D (1984): Salt sensitivity in humans is linked to enhanced sympathetic responsiveness and to enhanced proximal tubular reabsorption. Hypertension 6: 152–158.

    PubMed  CAS  Google Scholar 

  119. Weder AB (1986): Red cell lithium-sodium countertransport and renal lithium clearance. N Engl J Med 314: 198–201.

    Article  PubMed  CAS  Google Scholar 

  120. Weder AB, Fitzpatrick MA (1986): Lithium-sodium countertransport: Physiological moorings for red cell transport disorders in hypertension. J Cardiovasc Pharm 8(Suppl 5): S76–S81.

    Article  Google Scholar 

  121. Pettinger W, Sanchez A, Saavedra J, Haywood JR, Gandler T, Rodes T (1982): Altered renal alpha2-adrenergic receptor regulation in genetically hypertensive rats. Hypertension 4(suppl II): II-188–192.

    Google Scholar 

  122. Lin C, Lu H, Lin K (1982): Adrenergic receptors and increased reactivity of aortic smooth muscle in renal hypertensive rats. J Autonomic Nerv Sys 5: 253–264.

    Article  CAS  Google Scholar 

  123. Folkow B, Ely DL (1987): Dietary sodium effects on cardiovascular and sympathetic neuroeffector functions as studied in various rat models. J Hypertension 5: 383–395.

    Article  CAS  Google Scholar 

  124. Julius S, Esler M, Randall OS (1975): Role of the autonomic nervous system in mild human hypertension. Clin Sci Mol Med 48: 243s–252s.

    Google Scholar 

  125. Goldstein DS (1983): Plasma catecholamines and essential hypertension: An analytical review. Hypertension 5: 86–99.

    PubMed  CAS  Google Scholar 

  126. Esler M, Jennings G, Biviano B, Lambert G, Hasking G (1986): Mechanism of elevated plasma noradrenaline in the course of essential hypertension. J Cardiovasc Pharmacol 8(Suppl 5): S39–S43.

    Article  PubMed  Google Scholar 

  127. Levy RL, White PD, Stroud WD, Hillman CC (1945): Transient tachycardia: Prognostic significance alone and in association with transient hypertension. J Am Med Assoc 129: 585–588.

    Google Scholar 

  128. Cousineau D, DeChamplian J, LaPointe L (1978): Circulating catecholamines and systolic time intervals in labile and sustained hypertension. Clin Sci Mol Med 55: 65s–68s.

    CAS  Google Scholar 

  129. Lehner JP, Safar ME, Dimitriu VM, Simon A, Carrez JB, Plainfosse MT (1979): Systolic time intervals and echocardiographic findings in borderline hypertension. Europ J Cardiol 9(4): 319–331.

    CAS  Google Scholar 

  130. Egan B, Panis R, Hinderliter A, Schork N, Julius S (1987): Mechanism of increased alpha-adrenergic vasoconstriction in human essential hypertension. J Clin Invest 80: 812–817.

    Article  PubMed  CAS  Google Scholar 

  131. Lund-Johansen P (1980): State-of-the-art: Hemodynamics in essential hypertension. Clin Sci 59: 343s–354s.

    PubMed  Google Scholar 

  132. Bertel O, Bühler FR, Kiowski W, Lutold BD (1980): Decreased beta-adrenocepter responsiveness as related to age, blood pressure, and plasma catecholamines in patients with essential hypertension. Hypertension 2: 130–138.

    PubMed  CAS  Google Scholar 

  133. Trimarco B, Volpe M, Ricciardelli B, Picotti GB, Galva MD, Petracca R, Condorelli M (1983): Studies of the mechanisms underlying impairment of beta-adrenoceptor-mediated effects in human hypertension. Hypertension 5: 584–590.

    PubMed  CAS  Google Scholar 

  134. Messerli FH (1983): Clinical determinants and consequences of left ventricular hypertrophy. Am J Med 75(3A): 51–55.

    Article  PubMed  CAS  Google Scholar 

  135. Corea L, Bentivoglio M, Verdecchia P, Motolese M (1984): Plasma norepinephrine and left ventricular hypertrophy in systemic hypertension. Am J Cardiol 53: 1299–1303.

    Article  PubMed  CAS  Google Scholar 

  136. Egan B, Colfer H, Buda A, Julius S (1984): Evidence that the sympathetic nervous system contributes to cardiovascular hypertrophy in patients with borderline hypertension. Clin Res 32: 331A.

    Google Scholar 

  137. Shapiro LM, McKenna WJ (1984): Left ventricular hypertrophy: Relation of structure to diastolic function in hypertension. Br Heart J 51: 637–642.

    Article  PubMed  CAS  Google Scholar 

  138. Dianzumba SB, DiPette DJ, Cornman C, Weber E, Joyner CR (1986): Left ventricular filling characteristics in mild untreated hypertension. Hypertension 8(suppl I): I-156–160.

    Google Scholar 

  139. Conway J (1963): A vascular abnormality in hypertension: a study of blood flow in the forearm. Circulation 27: 520–529.

    PubMed  CAS  Google Scholar 

  140. Takeshita A, Mark AL (1980): Decreased vasodilator capacity of forearm resistance vessels in borderline hypertension. Hypertension 2: 610–616.

    PubMed  CAS  Google Scholar 

  141. Bevan RD (1975): Effect of sympathetic denervation on smooth muscle cell proliferation in the growing rabbit ear artery. Circ Res 37: 14–19.

    PubMed  CAS  Google Scholar 

  142. Egan B, Julius S (1985): Vascular hypertrophy in borderline hypertension: Relationship to blood pressure and sympathetic drive. Clin Exp Hypertens A7: 243–255.

    Article  Google Scholar 

  143. Folkow B (1978): Cardiovascular structural adaption: Its role in the initiation and maintenance of primary hypertension. Clin Sci Mol Med 55: 3s–22s.

    Google Scholar 

  144. Sivertsson R, Olander R (1968): Aspects of the nature of the increased vascular resistance and increased ‘reactivity’ to noradrenaline in hypertensive subjects. Life Sci 7(Part I): 1291–1297.

    Article  Google Scholar 

  145. Egan BM, Panis R, Hinderliter A, Schork N (1988): Vascular structure enhances regional resistance responses in mild hypertension. J Hypertension 6(1): 41–48.

    Article  CAS  Google Scholar 

  146. Lockette W, Otsuka Y, Carretero O (1986): The loss of endothelium-dependent vascular relaxation in hypertension. Hypertension 8(suppl II): II-61–66.

    CAS  Google Scholar 

  147. Matsuda H, Kuon E, Holtz J, Busse R (1985): Endothelium-mediated dilations contribute to the polarity of the arterial wall in vasomotion induced by α2-adrenergic agonists. J Cardiovasc Pharm 7: 680–688.

    Article  CAS  Google Scholar 

  148. Phillip Th, Distler A, Cordes U (1978): Sympathetic nervous system and blood-pressure control in essential hypertension. Lancet 1978/2: 959–963.

    Article  Google Scholar 

  149. Egan BM (1987): Changed sympathetic tone and responsiveness in the course of human essential hypertension, in: Julius S and Bassett DR (eds), Handbook of Hypertension, Vol 9: Behavioral Factors in Hypertension, Ch 15, pp 216–225. Amsterdam: Elsevier Science Publishers.

    Google Scholar 

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Egan, B.M., Julius, S. (1989). The hemodynamics of borderline hypertension. In: Safar, M.E., Fouad-Tarazi, F. (eds) The Heart in Hypertension. Developments in Cardiovascular Medicine, vol 98. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0941-0_6

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