Skip to main content
SpringerLink
Log in

Control of Breathing

  • Chapter
Anesthesia and the Lung

Part of the book series: Developments in Critical Care Medicine and Anaesthesiology ((DCCA,volume 19))

  • 77 Accesses

Abstract

The primary purpose of this presentation will be to explore the ways in which anesthetics and related drugs - sedatives, tranquilizers, and narcotics - act to produce one of their more notorious side effects, depression of breathing. I wi11 review dose-response relationships, discuss clinical implications, and explore some of the questions of basic ventilatory control revealed by the way in which these drugs modify breathing.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bainton, C.R. and Mitchell, R.A. Posthyperventi1ation apnea in awake man. J. Appl. Physiol. 21: 411–415, 1966.

    PubMed  CAS  Google Scholar 

  2. Biscoe, T.J. Millar, R.A. Effects of inhalation anaesthetics on carotid body chemoreceptor activity. Br. J. Anaesth. 40: 2–12, 1968

    Article  PubMed  CAS  Google Scholar 

  3. Bromage, P.R., Camporesi, E., and Leslie, J. Epidural narcotics in volunteers: sensitivity to pain and to carbon dioxide. Pain 9: 145–160, 1980.

    Article  PubMed  CAS  Google Scholar 

  4. Byrick, R.J. and Janssen, E.G. Respiratory waveform and rebreathing in T-piece circuits: a comparison of enflurane and halothane waveforms. Anesthesiology 53: 371–378, 1980.

    Article  PubMed  CAS  Google Scholar 

  5. Christensen, V . Respiratory depression after extradural morphine (Letter). Br. J. Anaesth. 52: 841, 1980

    Article  PubMed  CAS  Google Scholar 

  6. Clark, F.J. and Von Euler, C. On the regulation of depth and rate of breathing. J, Physiol. Lond. 222: 267–295, 1972.

    CAS  Google Scholar 

  7. Davies, R.O., Edwards, M.W., and Lahiri, S. Halothane depresses the response of carotid body chemoreceptors to hypoxia and hypercapnia in the cat. Anesthesiology 57: 153–159, 1982.

    Article  PubMed  CAS  Google Scholar 

  8. Doblar, D.D., Muldoon, S.M., Abbrecht, P.H., Baskoff, J., Watson, R.L. Epidural morphine following epidural local anesthesia: effect on ventilatory and airway occlusion pressure responses to COo. Anesthesiology 55: 423–428, 1981.

    Article  PubMed  CAS  Google Scholar 

  9. Eger, E.I., II, Dolan, W.M., Stevens, W.C., Miller, R.D., and Way, W.L. Surgical stimulation antagonizes the respiratory depression produced by Forane. Anesthesiology 36: 544–549, 1972.

    Article  PubMed  Google Scholar 

  10. Foldes, F.F., Duncalf, D., Kuwahara, S. The respiratory, circulatory, and narcotic antagonistic effects of nalorphine, levallorphan and naloxone in anaesthetized subjects. Can. Anaesth. Soc. J. 16: 151–161, 1969.

    CAS  Google Scholar 

  11. Glynn, C.J., Mather, L.E., Cousins, M.J., Wilson, P.R., Graham, J.R. Spinal narcotics and respiratory depression. Lancet 2: 356–357, 1979.

    Article  PubMed  CAS  Google Scholar 

  12. Hanks, E.C., Ngai, S.H., and Fink, B.R. The respiratory threshold during halothane anesthesia. Anesthesiology 22: 393–397, 1961.

    Article  PubMed  CAS  Google Scholar 

  13. Hickey, R.F., Fourcade, H.E., Eger, E.I., II, Larson, C.P., Bahlman, S.H., Stevens, W.M., Gregory, G.A., Smith, T.C. The effects of ether, halothane and Forane on apneic thresholds in man. Anesthesiology 35: 32–37, 1971.

    Article  PubMed  CAS  Google Scholar 

  14. Isaza, G.D., Posner, J.D., Altose, M.D., Kelsen, S.G., Cherniack, N.S. Airway occlusion pressures in awake and anesthetized goats. Respir. Physiol. 27: 87–98, 1976.

    Article  PubMed  CAS  Google Scholar 

  15. Kni11, R.L., Bright, S., Manninen, P.H. Hypoxic ventilatory responses during thiopentone sedation and anaesthesia in man. Can. Anaesth. Soc. J. 2: 366–372, 1978.

    Google Scholar 

  16. Kni11, R.L. Clement, J.L. Site of selective action of halothane on the peripheral chemoreflex pathway in humans. Anesthesiology 61: 121–126, 1984.

    Article  PubMed  CAS  Google Scholar 

  17. Knill, R.L. Clement, J.L. Ventilatory responses to acute metabolic acidemia in humans awake, sedated, and anesthetized with halothane. Anesthesiology 62: 745–753, 1985.

    Article  PubMed  CAS  Google Scholar 

  18. Knill, R.L., Clement, J.L., Thompson, W.R. Epidural morphine causes delayed and prolonged ventilatory depression. Can. Anaesth. Soc. J. 8: 537–543, 1981.

    Google Scholar 

  19. Knill, R.L. Gelb, A.W. Ventilatory response to hypoxia and hypercapnia during halothane sedation and anesthesia in man. Anesthesiology 49: 244–251, 1978.

    Article  PubMed  CAS  Google Scholar 

  20. Knill, R.L., Kieraszewicz, H., Dodgson, G.G., and Clement, J.L. Chemical regulation of ventilation during isoflurane sedation and anaesthesia in humans. Can. Anaesth. Soc. J 30: 607–614, 1983.

    Article  CAS  Google Scholar 

  21. Kryger, M.H., Yacoub, O., Dosman, J., Macklem, P.T., Anthonisen, N.R. Effect of meperidine on occlusion pressure responses to hypercapnia and hypoxia with and without external inspiratory resistance. Am. Rev. Respir. Dis. 114: 333–340, 1976

    PubMed  CAS  Google Scholar 

  22. Mitchell, R.A. Herbert, D.A. Potencies of doxapram and hypoxia in stimulating carotid-body chemoreceptors and ventilation in anesthetized cats. Anesthesiology 42: 559–566, 1975.

    Article  PubMed  CAS  Google Scholar 

  23. Moote, C. A., Knill, R.L., Clement, J. Ventilatory compensation for continuous inspiratory resistive and elastic loads during halothane anesthesia in humans. Anesthesiology 64: 582–589, 1986.

    CAS  Google Scholar 

  24. Munson, E.S., Larson, C.P., Jr., Babad, A.A., Regan, M.J., Buechel, D.R., Eger, E.I., II. The effects of halothane, fluroxene and cyclopropane on ventilation: a comparative study in man. Anesthesiology 27: 716–728, 1966.

    Article  PubMed  CAS  Google Scholar 

  25. Nunn, J.F., Ezi-Ashi, T.I. The respiratory effects of resistance to breathing in anesthetized man. Anesthesiology 22: 174–178, 1966.

    Article  Google Scholar 

  26. Pietak, S., Weenig, C.S., Hickey, R.F., Fairley, H.B. Anesthetic effects on ventilation in patients with chronic obstructive pulmonary disease. Anesthesiology 42: 160–166, 1975.

    Article  PubMed  CAS  Google Scholar 

  27. Pokorski, M., Barnard, P., McGregor, K., Lahiri, S. Dependence of ventilatory stimulation by naloxone on anesthesia and surgery in the cat (abstr.) Federation Proc. 42: 741, 1983

    Google Scholar 

  28. Polacheck, J., Strong, R., Arens, J., Davies, C., Metcalf, I., Younes, M. Phasic vagal influence on inspiratory motor output in anesthetized human subjects. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 609–619, 1980.

    CAS  Google Scholar 

  29. Santiago, T.V., Remolina, C., Scoles, V., Edelman, N.H. Endorphins and the control of breathing. N. Engl. J. Med. 304: 1190–1195, 1981

    Article  PubMed  CAS  Google Scholar 

  30. Savoy, J., Arnup, M.-E., and Anthonisen, N.R. Response to external inspiratory resistive loading and bronchospasm in anesthetized dogs. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 53: 355–360, 1982.

    CAS  Google Scholar 

  31. Savoy, J., Arnup, M.-E., and Anthonisen, N.R. Response to external inspiratory resistive loading and bronchospasm in anesthetized dogs. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 53: 355–360, 1982.

    CAS  Google Scholar 

  32. Tusiewicz, K., Bryan, A.C., Froese, A.B. Contributions of changing rib cage-diaphragm interactions to the ventilatory depression of halothane anesthesia. Anesthesiology 47:327–337, 1977

    Article  PubMed  CAS  Google Scholar 

  33. Ward, D.S . Stimulation of hypoxic ventilatory drive by droperidol. Anesth. Analg. Cleveland 63: 106–110, 1984

    Google Scholar 

  34. Weiskopf, R.B., Raymond, L.W., and Severinghaus, J.W. Effects of halothane on canine respiratory responses to hypoxia with and without hypercarbia. Anesthesiology 4: 350–360, 1974.

    Article  Google Scholar 

  35. Wheeler, M.E., Farber, J.P. Naloxone administration and ventilation in awake cats. Brain Res. 258:343–346, 1983.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology, University of Washington School of Medicine, 98195, Seattle, Washington, USA

    Thomas F. Hornbien

Authors
  1. Thomas F. Hornbien
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, The University of Utah Medical School, Salt Lake City, Utah, USA

    T. H. Stanley  & R. J. Sperry  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publisher

About this chapter

Cite this chapter

Hornbien, T.F. (1989). Control of Breathing. In: Stanley, T.H., Sperry, R.J. (eds) Anesthesia and the Lung. Developments in Critical Care Medicine and Anaesthesiology, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0899-4_5

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0899-4_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6893-2

  • Online ISBN: 978-94-009-0899-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation