Skip to main content

Part of the book series: NATO ASI Series ((NSSE,volume 156))

Abstract

The benefits and problems associated with the use of continuous cell lines (CCLs) for the production of various types of biological products have been discussed many times during the past few years (1, 2, 10). The purpose of this paper is to review past major events and more recent results which have led to the widening use of CCLs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beale AJ: Choice of cell substrate for biological products. Adv. Exp. Biol. Med. 118, 83–97, 1979.

    CAS  Google Scholar 

  2. Hayflick L, Plotkin S, and Stevenson RE: History of the acceptance of human diploid cell strains as substrates for human virus vaccine production. Develop. Biol. Standard. 68, 1987.

    Google Scholar 

  3. Hilleman MR: Cell line saga: an argument in favor of production of biologicals in cancer cells. Adv. Exp. Biol. Med. 118, 47–58, 1979.

    CAS  Google Scholar 

  4. Hopps HE and Petricciani JC (eds.): Abnormal Cells, New Products, and Risk. Tissue Culture Association, Gaithersburg, MD, 1985.

    Google Scholar 

  5. Lowy DR: Potential hazards from contaminating DNA that contains oncogenes. In: Abnormal Cells, New Products, and Risk (HE Hopps and JC Petricciani, eds.) pp 36–40, Tissue Culture Association, Gaithersburg, MD, 1985.

    Google Scholar 

  6. Perkins FT and Hennessen W (eds.): Use of Heteroploid and Other Cell Substrates for the Production of Biologicals. Karger, Basel 1982

    Google Scholar 

  7. Petricciani JC, Hopps HE and Chapple PH (eds.): Cell Substrates. Plenum, New York, 1979.

    Google Scholar 

  8. Petricciani JC and Regan PJ: Risk of neoplastic transformation from cellular DNA: calculations using the oncogene model. Develop. Biol. Standard. 68, 1987.

    Google Scholar 

  9. Salk J: The spector of malignancy and criteria for cell lines as substrates for vaccines. Adv. Exp. Biol. Med. 118, 107–113, 1979.

    CAS  Google Scholar 

  10. Tam JP: Physiological effects of transforming growth factor in the newborn mouse. Science 229, 673–675, 1985.

    Article  PubMed  CAS  Google Scholar 

  11. Wahl G: Detection of adventitious agents and sensitivity of methods. In: Abnormal Cells, New Products, and Risk (HE Hopps and JC Petricciani, eds.) pp 50–56, Tissue Culture Association, Gaithersburg, MD, 1985.

    Google Scholar 

  12. World Health Organization Technical Report Series, No. 747: Report of the WHO study group on biologicals: Acceptability of cell substrates for production of biologicals, Geneva, 1987.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers

About this chapter

Cite this chapter

Petricciani, J.C. (1989). Use of Cell Lines in Biotechnology. In: Miller, A.O.A. (eds) Advanced Research on Animal Cell Technology. NATO ASI Series, vol 156. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0875-8_5

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0875-8_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6881-9

  • Online ISBN: 978-94-009-0875-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics