Effects of Retinoids on Growth and Differentiation

  • Michael I. Sherman
Part of the NATO ASI Series book series (NSSE, volume 156)


The retinoids constitute a group of compounds which includes vitamin A (retinol), its metabolites and a multitude of synthetic analogues. Retinol can be oxidized to retinal and these two retinoids are essential for vision and fertility. Apart from eliciting these activities upon cells of the visual and reproductive systems, retinoids appear to have a much more general influence upon cellular behavior: they affect the propensity to differentiate and proliferate. Much of the information to support this view is derived from studies with cultured cells (reviewed in 1). However, it was recognized long ago (2,3) that in animals on diets lacking retinoids, epithelial cells showed evidence of both metaplasia and hyperplasia.


Retinoic Acid Embryonal Carcinoma Embryonal Carcinoma Cell Cloning Efficiency REtinoic Acid Treatment 
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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Michael I. Sherman
    • 1
  1. 1.Department of Oncology and VirologyRoche Research CenterNutleyUSA

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