Abstract
Since the discovery of the optical isomerism of tartaric acid by Louis Pasteur in 1848, the significance of stereoisomerism in relation to biological activity has been recognized. It was soon seen that the separation of a racemic mixture into its component stereoisomers presented a challenge of immensely greater magnitude than did the development of a stereospecific synthesis. As a result, efforts to resolve such mixtures were largely bypassed by scientists for more than a century. The rare instance of a successful separation was often treated either as happenstance or as the success of trial and error. In either event, a systematic approach to the problem was not seen as feasible, except in a few special cases. Clearly, commercial exploitation was unthinkable.
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De Camp, W.H. (1989). The importance of enantiomer separations. In: Lough, W.J. (eds) Chiral Liquid Chromatography. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0861-1_2
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DOI: https://doi.org/10.1007/978-94-009-0861-1_2
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6875-8
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