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The influence of cyclosporin A on T cell activation, cytokine gene expression and cell-mediated immunity

  • Chapter
Cyclosporin

Abstract

The potential of cyclosporin A (CsA) for the immunotherapy of allograft rejection and certain autoimmune disorders was evident in the first account by Borel et al. (1976) of the immunosuppressive properties of the drug. It was clear from such early publications that CsA exerted a powerful and selective inhibitory action against T lymphocytes. Whilst the capacity of CsA to abrogate the activation of CD4+ (T helper/inducer) lymphocytes and the secretion of interleukin-2 (IL-2) and other cytokines in vitro is now well recognized, the molecular basis of this remarkably sophisticated selectivity remains to be elucidated. Although the generation of specific cytotoxic T cells is impaired by CsA, the activity of natural cytotoxic cells (NK cells) appears unaffected.

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  1. Angus W. Thomson
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  2. Janet I. Duncan
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  1. Immunopathology Laboratory, Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen, AB9 2ZD, Scotland

    Angus W. Thomson BSc(Hons), MSc, PhD, DSc, MRCPath, FIBiol (Reader in Immunology) (Reader in Immunology)

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Thomson, A.W., Duncan, J.I. (1989). The influence of cyclosporin A on T cell activation, cytokine gene expression and cell-mediated immunity. In: Thomson, A.W. (eds) Cyclosporin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0859-8_4

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