Abstract
Brain imaging in psychiatry as well as in other medical fields aims at solving two fundamental problems:
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1.
Identification of structural alterations such as local or global atrophy.
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2.
Identification of functional alterations, for example of the regional cerebral blood flow or of metabolism.
Eating disorders, i.e. anorexia nervosa and bulimia nervosa, are characterized by continuous or intermittent fasting as a common means of losing weight. The question therefore arises whether the state of starvation can be held responsible for morphological and functional alterations found in both disorders. Pneumoencephalographic examinations, first carried out on dystrophic patients after years of war captivity, revealed a frequent enlargement of the anterior horns of the lateral ventricles, the anterior part of the cella media, the third ventricle and the external cerebrospinal fluid (CSF) spaces of the frontal area, presumably as a consequence of a brain edema due to protein depletion (1, 2). Comparable observations were made when investigating anorectic patients by means of post mortem autopsy (3), pneumoencephalography (4, 5) or cranial computed tomography (CCT) (6–15).
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References
Faust, C (1949). Hirnatrophie nach Hungerdystrophie. Nervenarzt, 23. Jahrg., Heft 11, 406
Schulte, W (1953). Hirnorganische Dauerschäden nach schwerer Dystrophie. (München, Berlin: Urban & Schwarzenberg )
Gagel, O (1953). Die Erkrankungen des vegetativen Systems. In: Bergman von G, Frey, W and Schwiegk, H (eds.) “Handbuch der Inneren Medizin”, vol. 5. p. 885. ( Berlin, Heidelberg, New York: Springer )
Geisler, E (1953). Zur Problematik der Magersucht. Psychiatr Neurol Med Psychol, 5, 227
Heidrich, R and Schmidt-Matthias, H (1961). Encepha- lographische Befunde bei Anorexia nervosa. Arch Psychiatr Nervenkr, 202, 183
Enzmann, DR and Lane, B (1977). Cranial computed tomography findings in anorexia nervosa. J Comput Assist Tomogr, 1, 410
Heinz, ER, Martinez, J and Haenggeli, A (1977). Reversibility of cerebral atrophy in anorexia nervosa and Cushing’s syndrome. J Comput Assist Tomogr, 1, 415
Nussbaum, M, Shenker R, Marc J and Klein, M (1980). Cerebral atrophy in anorexia nervosa. Brief clinical and laboratory observations, 96, 867
Sein, P, Searson, S, Nicol, AR and Hall, K (1981). Anorexia nervosa and pseudo-atrophy of the brain. Br J Psychiatry, 139, 257
Kohlmeyer, K, Lehmkuhl, G and Poutska, F (1983). Computed tomography of anorexia nervosa. A J N R, 4, 437
Artmann, H, Grau, H, Adelmann, M and Schleiffer, R (1985). Reversible and non-reversible enlargement of cerebrospinal fluid spaces in anorexia nervosa. Neuroradiology, 27, 304
Lankenau, H, Swigar, ME, Bhimani, S, Luchins, D and Quinlan, DM (1985). Cranial CT scans in eating disorder patients and controls. Compr Psychiatry, 26, 136
Sauer, H, Hornstein, Ch and Kessler, Ch (1985). Irreversible Hirnatrophie bei Anorexia nervosa. Nervenarzt, 56, 691
Datlof, S, Coleman, PD, Forbes, GB and Kreipe, RE (1986). Ventricular dilation on CAT scans of patients with anorexia nervosa. Am J Psychiatry, 143, 96
Deniker, P, Susini, JR, Ruyer, F and Fredy, D (1986). Apport de la tomodensitométrie cerébrale dans l’anorexie mentale. Etude de 16 cas. L’Encéphale, XII, 63
Krieg, J-C, Backmund, H and Pirke, K-M (1986). Endocrine, metabolic, and brain morphological abnormalities in patients with eating disorders. Int J Eating Disord, 5, 999
Krieg, J-C, Pirke, K-M, Lauer, C and Backmund, H (in press). Endocrine, metabolic and cranial computed tomographic findings in anorexia nervosa. Biol Psychiatry
Krieg, J-C, Backmund, H and Pirke, K-M (1987). Cranial computed tomography findings in bulimia. Acta Psychiatr Scand, 75, 144
Krieg, J-C, Lauer, C and Pirke, K-M (acc. for publ.). Structural brain abnormalities in patients with bulimia nervosa. Psychiatry Res
Krieg, J-C, Lauer, C, Leinsinger, G, Pahl, J, Schreiber, W, Pirke, K-M and Moser, EA (in prep.). Regional cerebral blood flow (rCBF) in anorexia nervosa
Feighner, JP, Robins, E, Guze, SB, Woodruff, RA, Winokur, G and Munoz, R (1972). Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry, 26, 57
Russell, GFM (1979). Bulimia nervosa: An ominous variant of anorexia nervosa. Psychol Med, 9, 429
American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders, 3rd ed. ( Washington, D.C.: American Psychiatric Association )
Metropolitan Life Insurance Co. (1959). Statistical Bulletin of the Metropolitan Life Insurance Co., 40, 1
Bill 133U, Moser, EA, Kirsch, CM and Schmiedek, P (1983). Xe-DSPECT (Dynamische Single Photon Emissions CT). Fortschr. Röntgenstr., 139, 351
Buell, U, Moser, EA, Schmiedek, P, Leinsinger, G, Kreisig, T, Kirsch, CM and Einhdupl, K (1984). Dynamic SPECT with Xe-133: Regional cerebral blood flow in patients with unilateral cerebrovascular disease: concise communication. J Nucl Med, 25, 441
Pirke, K-M, Pahl, J, Schweiger, U and Warnhoff, M (1985). Metabolic and endocrine indices of starvation in bulimia: a comparison with anorexia nervosa. Psychiatry Res, 15, 33
Momose, KJ, Kjellberg, RN and Kliman, B (1971). High incidence of cortical atrophy of the cerebral and cerebellar hemispheres in Cushing’s disease. Radiology, 99, 341
Bentson, J, Reza, M, Winter, J and Wilson, G (1978). Steroids and apparent cerebral atrophy on computed tomography scans. J Comput Assist Tomogr, 2, 16
Gordon, N (1980). Apparent cerebral atrophy in patients on treatment with steroids. Dev Med Child Neurol, 22, 502
Kellner, CH, Rubinow, DR, Gold, PW and Post, RM (1983). Relationship of cortisol hypersecretion to brain CT scan alterations in depressed patients. Psychiatry Res, 8, 191
Church, A and Peterson, F (1903). “Nervous and Mental Diseases”, 4th ed., rev. p. 496. ( Philadelphia, New York, London: W.B. Saunders )
Weller, RO, Swash, M, McLellan, DL and Scholtz, CL (1983). “Clinical Neuropathology”. p. 237. ( Berlin, Heidelberg, New York: Springer )
Jellinek, EH (1962). Fits, faints, coma, and dementia in myxoedema. The Lancet, 3, 1010
Johnstone, EC, Owens, DGC, Crow, TJ, Colter, N, Lawton, CA, Jagoe, R and Kreel, L (1986). Hypothyroidism as a correlate of lateral ventricular enlargement in manic-depressive and neurotic illness. Br J Psychiatry, 148, 317
Levy, LL (1958). The EEG in thyroid and parathyroid disease. Electroencephalogr Clin Neurophysiol, 10, 366
Bertrand, I, Delay, J and Guillain, J (1938). L’électro-encéphalogramme dans le myxoedéme. Compt Rend Soc de Biol, 129, 395
Crisp, AH, Fenton, GW and Scotton, L (1968). A controlled study of the EEG in anorexia nervosa. Br J Psychiatry, 114, 1149
Neil, JF, Merlkangas, JR, Foster, FG, Merlkangas, KR, Spiker, DG and Kupfer, DJ (1980). Waking and all-night sleep EEG’s in anorexia nervosa. Clin Electroencephalogr, 11, 9
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Schreiber, W. et al. (1990). The impact of starvation on brain morphology and function in eating disorders. In: Cazzullo, C.L., Sacchetti, E., Conte, G., Invernizzi, G., Vita, A. (eds) Plasticity and Morphology of the Central Nervous System. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0851-2_9
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DOI: https://doi.org/10.1007/978-94-009-0851-2_9
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