A neurodevelopmental perspective on some epiphenomena of schizophrenia

  • R. M. Murray
  • M. J. Owen
  • R. Goodman
  • S. W. Lewis


Although both Kraepelin and Eugene Bleuler believed that schizophrenia was usually a deteriorating disorder, influential voices now question this. For example, Manfred Bleuler[1] estimated that 25% of his cases recovered completely, 50% ran a fluctuating course, while only 10% showed severe and permanent impairment. Several other follow-up studies have shown a more benign outcome than the traditional view would have predicted[2–4]. This has lead Zubin[5] to dispute the existence of any underlying disease process, and to postulate instead a ‘vulnerability model’ in which the schizophrenic individual is seen as characterised by some permanent predisposition to episodes of illness.


Schizophrenic Patient Temporal Lobe Epilepsy Obstetric Complication Septum Pellucidum Soft Neurological Sign 
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© Kluwer Academic Publishers 1990

Authors and Affiliations

  • R. M. Murray
  • M. J. Owen
  • R. Goodman
  • S. W. Lewis

There are no affiliations available

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