Amish study of genetics of affective disorders
This paper will review the epidemiologic and genetic studies of major affective disorders among the Old Order Amish of Pennsylvania. The Amish Study has been funded for a 14 year period (1976–1990) by the National Institute of Mental Health. It was designed and directed by J.A. Egeland, who began a series of a studies on the Amish in 1959 and has developed close ties to the community over time. The academic base of the study has been the Department of Psychiatry of the School of Medicine, University of Miami, Florida. The work has fostered an interface between psychiatry, epidemiology, human genetics and molecular biology. There has been collaboration with eleven schools of medicine and a number of laboratories providing the research teams needed to address different clinical and genetic studies.
KeywordsHuman Leukocyte Antigen Affective Disorder Amish Study Bipolar Affective Disorder Tyrosine Hydroxylase Gene
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