Recent Observations Concerning the Relationship of Blood Lead to Erythrocytic Protoporphyrin

  • P. A. Succop
  • P. B. Hammond
  • R. L. Bornschein
  • S. B. Roda
  • R. D. Greenland

Summary

Blood lead concentration (PbB) and erythrocytic protoporphyrin concentration (EP) are both used as indices of lead exposure in children and in occupationally exposed adults. In a previous study we reported dose- effect and dose-response relationships, in EP vs. PbB (Hammond et al, 1985). In the present study we report the influence of age on the threshold for an EP response to PbB, as well as on the slope of the dose-effect interaction. In the age range 12–30 months the threshold for effect of PbB on EP falls progressively, while the magnitude of the dose-effect increases with age. The rate of decline in the threshold for In EP and the rate of increase for ln EP·PbB-1 are linearly related to age.

Keywords

Lead Exposure Blood Lead Level Adenosine Triphosphatase Blood Lead Concentration Zinc Protoporphyrin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bellinger, P., Leviton, A., Needleman, H.L., Waternaux, C. and Rabinowitz, M. (1986) Low- level lead exposure and infant development in the first year. Neurobehav. Toxicol. Teratol., 8, 151–161PubMedGoogle Scholar
  2. Chisolm, J.J. and Brown, P. (1975) Micro-scale photofluorometric determination of free erythrocyte porphyrin (protoporphyrin IX). Clin. Chem., 21, 1669–1682PubMedGoogle Scholar
  3. Dietrich, K.N., Krafft, K.M., Shukla, R., Bornschein, R.L. and Succop, P.A. (1986) The neurobehavioral effects of prenatal and early postnatal lead exposure. In Schroeder, S.R. (ed.), Toxic Substances and Mental Retardation: Neurobehavioral Toxicology and Teratology ( Washington, DC: AAMD Monograph Series )Google Scholar
  4. Hammond, P.B., Lerner, S.J., Gartside, P.S., Hanenson, J.B., Roda, S.B., Foulkes, E.C., Johnson, D.R. and Pesce, A.J. (1980). The relationship of biological indices of lead exposure to the health status of workers in a secondary lead smelter. J. Occup. Med., 22, 475–484PubMedGoogle Scholar
  5. Hammond, P.B., Bornschein, R.L. and Succop, P. (1985) Dose-effect and dose-response relationships of blood lead to erythrocytic protoporphyrin in young children. Environ. Res., 38, 187–196PubMedCrossRefGoogle Scholar
  6. Lamola, A.A., Joselow, M. and Yamane, T. (1975) Zinc protoporphyrin (ZPp): a simple, sensitive fluorometric screening test for lead poisoning. Clin. Chem., 21, 93–97PubMedGoogle Scholar
  7. Lilis, R., Fischbein, A., Diamond, S., Anderson, H.A., Selikoff, J.J., Blumberg and W.E., Eisinger, J. (1977) Lead effects among secondary lead smelter workers with blood lead levels below 80 µg/100 ml. Arch. Environ. Health, 32, 256–266PubMedGoogle Scholar
  8. NAS-NRC (1972) Airborne Lead in Perspective ( Washington, DC: National Academy of Sciences )Google Scholar
  9. Piomelli, S., Seaman, C., Zullow, D., Curran, A. and Davidow, B. (1982) Threshold for lead damage in heme synthesis in urban children. Proc. Natl. Acad. Sci. USA, 79, 3335–3339PubMedCrossRefGoogle Scholar
  10. Raghavan, S.R.V., Culver, B.D. and Gonick, H.C. (1981) Erythrocyte lead-binding protein after occupational exposure. II. Influence on lead inhibition of membrane Na+,K+- adenosinetriphosphatase. J. Toxicol. Environ. Health, 7, 561–568PubMedCrossRefGoogle Scholar
  11. Spivey, G.H., Brown, C.P., Baloh, R.W., Campion, D.S., Valentine, J.L., Massey, F.J., Browdy, B.L. and Culver, B.P. (1979) Subclinical effects of chronic increased lead absorption - a prospective study. 1. Study design and analysis of symptoms. J. Occup. Med., 21, 423–429PubMedGoogle Scholar
  12. Valciukas, J.A., Lilis, R., Eisinger,J., Blumberg, W.E., Fischbein, A. and Selikoff, FJ. (1978) Behavioral indicators of lead neurotoxicity: results of a clinical field survey. Int. Arch. Occup. Environ. Health, 41, 217–236PubMedCrossRefGoogle Scholar

Copyright information

© ECSC-EEC-EAEC, Brussels — Luxembourg; EPA, USA 1989

Authors and Affiliations

  • P. A. Succop
  • P. B. Hammond
  • R. L. Bornschein
  • S. B. Roda
  • R. D. Greenland

There are no affiliations available

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