Recent Observations Concerning the Relationship of Blood Lead to Erythrocytic Protoporphyrin
Blood lead concentration (PbB) and erythrocytic protoporphyrin concentration (EP) are both used as indices of lead exposure in children and in occupationally exposed adults. In a previous study we reported dose- effect and dose-response relationships, in EP vs. PbB (Hammond et al, 1985). In the present study we report the influence of age on the threshold for an EP response to PbB, as well as on the slope of the dose-effect interaction. In the age range 12–30 months the threshold for effect of PbB on EP falls progressively, while the magnitude of the dose-effect increases with age. The rate of decline in the threshold for In EP and the rate of increase for ln EP·PbB-1 are linearly related to age.
KeywordsLead Exposure Blood Lead Level Adenosine Triphosphatase Blood Lead Concentration Zinc Protoporphyrin
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