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Studies on Lead and Blood—Brain Barrier Function in the Developing Rat

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Lead Exposure and Child Development

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Summary

Blood-brain barrier function was assessed in two lead exposure models using 19–21-day-old rats. In animals receiving lead via the milk, blood lead ranged between 20 and 90 µg/dl without affecting growth. Cerebrovascular permeability (PS-product) was increased to basic and neutral amino acids and thiamine in certain regions of the cerebral hemisphere. Regional permeability to mannitol was unchanged. These alterations may have been due to tissue repair processes or to delayed maturation. In animals infused with lead to maintain steady plasma levels up to 764 µg/dl, blood—brain barrier integrity was unaffected but regional glucose uptake was inhibited.

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Authors
  1. D. Pelling
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  2. R. J. Hargreaves
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  3. S. R. Moorhouse
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Editor information

Editors and Affiliations

  1. Department of Child Psychiatry, Institute of Child Health Hospital for Sick Children, Great Ormond Street, London, UK

    M. A. Smith

  2. Environmental Criteria and Assessment Office Office of Health and Environment Assessment US Environmental Protection Agency, Research Triangle Park, 27711, NC, USA

    L. D. Grant (Director) (Director)

  3. Environment Research Programme, Commission of the European Communities, Rue de la Loi 200, B-1049, Brussels, Belgium

    A. I. Sors (Directorate-General for Science, Research and Development) (Directorate-General for Science, Research and Development)

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© 1989 ECSC-EEC-EAEC, Brussels — Luxembourg; EPA, USA

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Pelling, D., Hargreaves, R.J., Moorhouse, S.R. (1989). Studies on Lead and Blood—Brain Barrier Function in the Developing Rat. In: Smith, M.A., Grant, L.D., Sors, A.I. (eds) Lead Exposure and Child Development. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0847-5_30

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  • DOI: https://doi.org/10.1007/978-94-009-0847-5_30

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6868-0

  • Online ISBN: 978-94-009-0847-5

  • eBook Packages: Springer Book Archive

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