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The Role of 5-Hydroxytryptamine (5-HT; Serotonin) in Glucose Transport, Intermediary Carbohydrate Metabolism and Helminth Neurobiology

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Comparative Biochemistry of Parasitic Helminths

Abstract

5-HT is synthesised in the enterochromaffin cells of the intestinal mucosa of mammals, particularly in the proximal intestine. 5-HT is secreted into the intestinal lumen; some enters the blood stream where it is taken up by blood platelets. 5-HT stimulates glucose uptake by Hymenolepis diminuta and Schistosoma mansoni, but reduces worm glycogen levels; 5-HT does not stimulate glucose uptake in H. microstoma, but does reduce glycogen levels. The primary function of 5-HT appears to be an increase in the rate of carbon flux through the intermediary pathways of carbohydrate metabolism. 5-HT also acts as putative neurotransmitter in Fasciola hepatica, H. diminuta and Dipylidium caninum. In H. diminuta 5-HT has more consistent excitatory effects on the circular muscles than on the longitudinal muscles. Motility responses to 5-HT by the scolex suckers and the strobila are concentration dependent There is evidence that glutamate, and not 5-HT, acts as an excitatoiy putative neurotransmitter on the longitudinal musculature of H. diminuta.

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Authors and Affiliations

  1. Department of Zoology, University of Toronto, Toronto, Ontario, Canada, M5S 1A1

    D. F. Mettrick F.R.S.(C)

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  1. D. F. Mettrick F.R.S.(C)
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  1. Australian National University, Australia

    Eva-Maria Bennet (Laboratory Co-ordinator) (Laboratory Co-ordinator)

  2. Australian National University, Australia

    Carolyn Behm (Lecturer in Biochemistry) (Lecturer in Biochemistry)

  3. Australian National University, Australia

    Christopher Bryant (Professor of Zoology and Dean of the Faculty of Science) (Professor of Zoology and Dean of the Faculty of Science)

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Mettrick, D.F. (1989). The Role of 5-Hydroxytryptamine (5-HT; Serotonin) in Glucose Transport, Intermediary Carbohydrate Metabolism and Helminth Neurobiology. In: Bennet, EM., Behm, C., Bryant, C. (eds) Comparative Biochemistry of Parasitic Helminths. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0833-8_2

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  • DOI: https://doi.org/10.1007/978-94-009-0833-8_2

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