Abstract
Many antimicrobial substances inhibit protein biosynthesis. In most cases the inhibition involved one or other of the events which take place on the ribosomes. Only a few agents inhibit either amino acid activation or the attachment of the activated amino acid to the terminal adenylic acid residue of transfer RNA (tRNA). There are many chemical types to be found among the inhibitors of protein synthesis, a fact which has increased the difficulty of understanding the molecular nature of their inhibitory effects. Indeed, while the reaction which is inhibited has been identified with some precision in certain instances, the nature of the molecular interaction between the sensitive site and inhibitor remains generally elusive.
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Further Reading
Chopra, I. (1985) Mode of action of the tetracyclines and the nature of bacterial resistance to them. Handb. Exp. Pharmacol., 78, 313.
Cundliffe, E. (1986) Thiostrepton and the ribosomal GTPase center. In Structure, Function and Genetics of Ribosomes (eds B. Hardesty and G. Kramer), Springer Verlag, p. 590.
Davis, B. D. (1987) Mechanism of bactericidal action of aminoglycosides. Microbiol. Rev., 51, 341.
Gale, E. F., Cundliffe, E., Reynolds, P. E., Richmond, M. and Waring, M. J. (1981) The Molecular Basis of Antibiotic action, 2nd edn., John Wiley and Sons, London.
Hardesty, B. and Kramer, G. (eds) (1986) Structure, Function and Genetics of Ribosomes, Springer Series in Molecular Biology, Springer Verlag.
Jelenc, P. C. and Kurland, G. G. (1984) Multiple effects of kanamycin on translational accuracy. Mol. Gen. Genet., 194, 195.
Kaji, A. and Ryoji, M. (1979) Tetracycline. In Antibiotics, Vol. 5, Part 1 (ed. F. E. Hahn), Springer Verlag, p. 304.
Lake, J. A. (1985) Evolving ribosome structure: Domains in Archaebacteria, Eubacteria, Eocytes and Eukaryotes. Annu. Rev. Biochem., 54, 507.
Menninger, J. R. and Otto, D. P. (1982) Erythromycin, carbomycin and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. Antimicrob. Ag. Chemother., 21, 811.
Omura, S. (1984) Macrolide Antibiotics: Chemistry, Biology and Practice, Academic Press, London.
Skeggs, P. A., Thompson, J. and Cundliffe, E. (1985) Methylation of 16S rRNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis. Mol. Gen. Genet., 200, 415.
Stoffler, G. and Stoffler-Meilicke, M. (1981) Structural organisation of E. coli ribosomes and localisation of functional domains. In International Cell Biology (ed. H. G. Schweiger), Springer Verlag, p. 93.
Stoffler, G. and Stoffier-Meilicke, M. (1984) Immuno-electron microscopy of ribosomes. Annu. Rev. Biophys. Bioeng., 13, 303.
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© 1989 T. J. Franklin and G. A. Snow
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Franklin, T.J., Snow, G.A. (1989). Inhibitors of protein synthesis. In: Biochemistry of Antimicrobial Action. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0825-3_5
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DOI: https://doi.org/10.1007/978-94-009-0825-3_5
Publisher Name: Springer, Dordrecht
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