Inhibitors of protein synthesis
Many antimicrobial substances inhibit protein biosynthesis. In most cases the inhibition involved one or other of the events which take place on the ribosomes. Only a few agents inhibit either amino acid activation or the attachment of the activated amino acid to the terminal adenylic acid residue of transfer RNA (tRNA). There are many chemical types to be found among the inhibitors of protein synthesis, a fact which has increased the difficulty of understanding the molecular nature of their inhibitory effects. Indeed, while the reaction which is inhibited has been identified with some precision in certain instances, the nature of the molecular interaction between the sensitive site and inhibitor remains generally elusive.
KeywordsDonor Site Ribosomal Subunit Protein Biosynthesis Acceptor Site Fusidic Acid
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