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Inhibitors of protein synthesis

  • T. J. Franklin
  • G. A. Snow

Abstract

Many antimicrobial substances inhibit protein biosynthesis. In most cases the inhibition involved one or other of the events which take place on the ribosomes. Only a few agents inhibit either amino acid activation or the attachment of the activated amino acid to the terminal adenylic acid residue of transfer RNA (tRNA). There are many chemical types to be found among the inhibitors of protein synthesis, a fact which has increased the difficulty of understanding the molecular nature of their inhibitory effects. Indeed, while the reaction which is inhibited has been identified with some precision in certain instances, the nature of the molecular interaction between the sensitive site and inhibitor remains generally elusive.

Keywords

Donor Site Ribosomal Subunit Protein Biosynthesis Acceptor Site Fusidic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Further Reading

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Copyright information

© T. J. Franklin and G. A. Snow 1989

Authors and Affiliations

  • T. J. Franklin
  • G. A. Snow

There are no affiliations available

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