Secondary Metabolites by Extractive Fermentation
Product yield infermentation processes is often limited by product inhibition or degradation. This may be avoided by extracting the product from the broth during fermentation. Solvents to be used in these extractive fermentations must be selective for the product and non-toxic for the microorganism. For the formation of cycloheximide by Streptomyces griseus and gibberellic acid by Gibberella fujikuroi the procedure of solvent selection is exemplified. It is shown that substituted polyglycols are well suited for the requirements of extractive fermentations of secondary metabolites. Furthermore, process variants for performing an extractive fermentation are presented.
KeywordsSecondary Metabolite Gibberellic Acid Polyethylene Glycol Extract Phase Product Inhibition
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