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Secondary Metabolites by Extractive Fermentation

  • Dirk Hollmann
  • Ute Merrettig-Bruns
  • Ulrich Müller
  • Ulfert Onken

Abstract

Product yield infermentation processes is often limited by product inhibition or degradation. This may be avoided by extracting the product from the broth during fermentation. Solvents to be used in these extractive fermentations must be selective for the product and non-toxic for the microorganism. For the formation of cycloheximide by Streptomyces griseus and gibberellic acid by Gibberella fujikuroi the procedure of solvent selection is exemplified. It is shown that substituted polyglycols are well suited for the requirements of extractive fermentations of secondary metabolites. Furthermore, process variants for performing an extractive fermentation are presented.

Keywords

Secondary Metabolite Gibberellic Acid Polyethylene Glycol Extract Phase Product Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© SCI 1990

Authors and Affiliations

  • Dirk Hollmann
    • 1
  • Ute Merrettig-Bruns
    • 1
  • Ulrich Müller
    • 1
  • Ulfert Onken
    • 1
  1. 1.Lehrstuhl Technische Chemie BUniversität DortmundDortmund 50Germany

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