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Batch Stirred Tank Adsorption of Impurity of Cephalosporin C, Desacetylcephalosporin C, Using Modified Amberlite XAD-2 Resin

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Separations for Biotechnology 2

Abstract

The adsorption of desacetylcephalosporin C from an aqueous solution onto particles of a modified macroporous Amberlite XAD-2 resin, XAD-2-CH2-CH2-Br, using a batch stirred tank is described. The pH studies used 2.8, at 293.15 K and an ionic strength 0.1 M. Equilibrium adsorption experiments showed that a linear adsorption isotherm is appropriate to describe the adsorption on the modified resin. A theoretical model has teen developed to simulate adsorption in a batch stirred tank and includes the effects of mass transfer from the bulk liquid to the surface of the particle and diffusion within the pores of the resin, with a linear isotherm. Basic parameters such as the isotherm relationships, effective diffusivities and tortuosity factor have been determined.

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References

  1. K Weisenberger. Downstream Processing of Cephalosporin C. PhD dissertation, University of Cambridge, 1987.

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  2. M Martinez, J Aracil, F Addo-Yobo, C N Kenney. Dechema Biotechnology Conference, 83-90 (1988).

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  5. M Martinez, J Aracil, F Adoo-Yobo, C N Kenney. Proceedings of the 5th Mediterranean Congress on Chemical Engineering, Barcelona (1990).

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Author information

Authors and Affiliations

  1. Departamento de Ingenieria Quimica, Universidad Complutense, Spain

    J. L. Casillas, J. L. Garrido & J. Aracil

  2. Departmento de Inginieria Quimica (ETSIM), Universidad Politecnica, Spain

    M. Martinez

  3. Department of Chemical Engineering, University of Cambridge, UK

    F. Addo-Yobo & C. N. Kenney

Authors
  1. J. L. Casillas
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  2. J. L. Garrido
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  3. J. Aracil
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  4. M. Martinez
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  5. F. Addo-Yobo
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  6. C. N. Kenney
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Editor information

Editors and Affiliations

  1. Biotechnology Group, University of Reading, UK

    D. L. Pyle

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© 1990 SCI

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Casillas, J.L., Garrido, J.L., Aracil, J., Martinez, M., Addo-Yobo, F., Kenney, C.N. (1990). Batch Stirred Tank Adsorption of Impurity of Cephalosporin C, Desacetylcephalosporin C, Using Modified Amberlite XAD-2 Resin. In: Pyle, D.L. (eds) Separations for Biotechnology 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0783-6_31

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  • DOI: https://doi.org/10.1007/978-94-009-0783-6_31

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6839-0

  • Online ISBN: 978-94-009-0783-6

  • eBook Packages: Springer Book Archive

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