Vortex Flow Filtration for Ultrafiltration of Protein Solutions

  • Charles L. Cooney
  • Ulrich Holeschovsky
  • Gopal Agarwal


The induction of secondary flow by Taylor vortices during ultrafiltration of protein solutions provides a means to enhance this unit operation. Vortex flow filtration is readily implemented by placing a membrane on a high speed rotating cylinder in a narrow annular gap. The resulting increase in mass transfer coefficient makes the filtration dependent on membrane properties such that filtration flux is controlled by membrane permeability and protein transmission is enhanced.


Rotation Rate Mass Transfer Coefficient Secondary Flow Concentration Polarization Taylor Vortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    .Cheryan, M., Ultrafiltration Handbook. Technomic Publishing Co., Lancaster, PA, 1986.Google Scholar
  2. 2.
    Kroner, K. H. and H. Hustedt, Separation of enzymes from cell homogenates by means of a dynamic filtration. Dechema Biotechnology Conferences 1-VCH Verlagsgesellschaff 1988, pp 477-483.Google Scholar
  3. 3.
    .Hildebrandt, J. R. and Sax ton, J. B., The use of Taylor vortices in protein processing to enhance membrane filtration performance, Bioprocess Engineering Colloquium Ed. Dean, R.C. and Nerem, R.M., American Society of Mechanical Engineers, New York, pp. 93–96, 1987.Google Scholar
  4. 4.
    Rushton, A. and Zhang, G. S., Rotary Microporous Filtration of Organic and Inorganic Particulates. I. Chem. E. Series No. 113, European Federation of Chemical Engineering Publication N. 72, 1989.Google Scholar
  5. 5.
    .Lopez-Leiva, M., Ultrafiltration at low degrees of concentration polarization: technical possibilities, Desalination, vol. 35, 115–128, 1980.Google Scholar
  6. 6.
    Holeschovsky, U. and Cooney, C. L. Quantitative Description of Ultrafiltration in Rotating Filtration Device. Am. Inst. Ch. Engr. Journal, (submitted).Google Scholar

Copyright information

© SCI 1990

Authors and Affiliations

  • Charles L. Cooney
    • 1
  • Ulrich Holeschovsky
    • 1
  • Gopal Agarwal
    • 1
  1. 1.Biotechnology Process Engineering Center and Department of Chemical EngineeringMassachusetts Institute of TechnologyCambridgeUSA

Personalised recommendations