Concentration and Selectivity in Bioseparations

  • D. L. Pyle


This brief chapter is a personal reflection on some of the aspects involved in attempting to reconcile simultaneously the objectives of concentration and selective purification of bioproducts. The review is written from a process engineering perspective, and it attempts to provide a context for the many papers in this volume addressing these problems, and also to identify problems and targets which are worthy of research and development.


Reverse Micelle Mass Transfer Limitation Supported Liquid Membrane Nisin Production Liquid Emulsion Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Datar, R. Economics of primary separation steps in relation to fermentation and genetic engineering. Proc. Biochem. 1986 (Feb),19-26.Google Scholar
  2. [2]
    Schugerl, K., Degner, W., Frieling P v.,Handojo, L. and Kirigios, I. Separation of low-molecular organic compounds from complex aqueous mixtures by extraction. This volume. 1990.Google Scholar
  3. [3]
    Belter, P.A., Cussler, E.L. and Hu, W-S. Bioseparations. 1988. Wiley & Sons, N.Y.Google Scholar
  4. [4]
    Chaudhuri, J.B. and Pyle, D.L. A model for liquid emulsion membrane extraction of organic acids. This volume. 1990.Google Scholar
  5. [5]
    Sirman, T.,Grandison, A.S. and Pyle, D.L. Extraction of organic acids using a supported liquid membrane. This volume. 1990.Google Scholar
  6. [6.]
    eg Abbott, N.L. and Hatton, T.A. 1988. Chem. Eng. Progress. 31-41.Google Scholar
  7. [7]
    Zlokarnik, M. Trends and needs in bioprocess engineering. Chem.Engng. Progr. 1990. 86(4), 62–67.Google Scholar
  8. [8]
    Cooney C.L., Holechovsky, U. and Agarwal G. Vortex flow filtration for ultrafiltration of protein solutions. This volume. 1990.Google Scholar
  9. [9]
    Chase, H.A. The future of high resolution purification. This volume. 1990.Google Scholar
  10. [10]
    Afeyan N.B., Fulton, S.P., Gordon N.F., Mazsaroff, I., Varady, L. and Regnier F.E. Perfusion Chromatography: an approach to purifying biomolecules. 1990. Bio/Technology, 8, 203–206.CrossRefGoogle Scholar

Copyright information

© SCI 1990

Authors and Affiliations

  • D. L. Pyle
    • 1
  1. 1.Biotechnology Group, Department of Food Science and TechnologyUniversity of ReadingUK

Personalised recommendations