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Tumours of the Macrophage Series

  • Su-Ming Hsu
Chapter
Part of the Immunology and Medicine Series book series (IMME, volume 15)

Abstract

The two major categories of true histiocytic malignancies, which are derived from the mononuclear phagocytic system (MPS) are true histiocytic lymphoma (THL) and malignant histiocytosis (MH). Although the clinicopathologic findings overlap, the two disorders can be distinguished by their unique expression of immunologic markers1. The term ‘malignant histiocytosis’ was first used by Rappaport to describe a systemic malignancy of histiocytes which affects the entire reticuloendothelial system from the beginning2. A similar disease entity called ‘histiocytic medullary reticulosis’ (HMR) was defined by Robb-Smith in 19393, but many investigators have regarded the terms MH and HMR as synonymous4–6. True histiocytic lymphoma, on the other hand, is a localized malignancy which may or may not progress to disseminated disease7.

Keywords

Lymphoproliferative Disease Histiocytic Lymphoma Mononuclear Phagocytic System Malignant Histiocytosis Interdigitating Reticulum Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Kluwer Academic Publishers 1990

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  • Su-Ming Hsu

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