T-cell Neoplasia

  • A. D. Ramsay
  • W. J. Smith
Part of the Immunology and Medicine Series book series (IMME, volume 15)


The T-cell arises from an undifferentiated mesenchymal precursor cell probably originating in the bone marrow, and undergoes processing in the thymus. It is unclear whether the stem cell is committed to becoming a T-cell before this processing, or if the thymus itself induces T-cell differentiation. During development, at around 8 weeks gestation, the thymus gland, which is initially epithelial in nature, becomes filled with lymphoid cells. Lymphopoiesis then commences and continues until infancy when the thymus reaches its maximum size (around 70 g), and subsequently decreases with age as the gland involutes1.


High Endothelial Venule Lymphoblastic Lymphoma Malignant Histiocytosis Lymphomatoid Papulosis Angioimmunoblastic Lymphadenopathy 
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© Kluwer Academic Publishers 1990

Authors and Affiliations

  • A. D. Ramsay
  • W. J. Smith

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