Advertisement

Lipid and apolipoprotein in cord blood

  • M. R. Averna
  • C. M. Barbagallo
  • S. Amato
  • G. Di Paola
  • G. Marino
  • M. Labisi
  • U. Dimita
  • A. Notarbartolo

Abstract

In this study a series of Sicilian neonates was studied in order to investigate about the distribution of serum lipid and apolipoprotein at birth and the differences with adults. A series of 200 term, healthy newborns was studied. Total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), apo AI and apo B were assayed in all cord blood samples. TC mean value was 63.2 mg/dl and HDL-C represented about the 40% of TC: no differences was found between male and female newborns. In neonates TC and LDL-C were about, three-fold lower than adults, while HDL-C was about the 60%; apo AI and apo B were respectively about 60% and 30% of adult levels. 3.5% of newborns presented TC levels above the mean + 2 standard deviations. In conclusion lipid and apolipoprotein distributions in Sicilian newborns are not different from that of other population and there are no differences between males and females. It should be interesting the follow up of “hypercholesterolemic” newborns in order to establish if it is possible to do a neonatal screening of familial hypercholesterolemia.

Keywords

Total Cholesterol Cord Blood Familial Hypercholesterolemia Adult Level Cord Blood Sample 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Barnes, K., Nestel, P.J., Pryke, E.S., Whyte, H.M. (1972) “Neonatal plasma lipids”, Med. J. Aust., 28, 1002–5.Google Scholar
  2. 2.
    Brody, S., Carlson, L.A., (1962) “Plasma lipid concentration in the newborn with special reference to the distribution of the different lipid fractions”, Clin. Chim. Acta, 7, 694–99.CrossRefPubMedGoogle Scholar
  3. 3.
    Glueck, C.J., Heckman, F., Schoenfeld, M., Steiner, P.M., Pearce, W., (1971) “Neonatal familial type II hyperlipoproteinemia: cord blood cholesterol in 1800 births”, Metabolism, 20, 597–608.CrossRefPubMedGoogle Scholar
  4. 4.
    Greten, H., Wengler, H., Wagner, H., (1973) “Early diagnosis of familial type II hyperlipoproteinemia” Nutr. Metab. 15, 1128–33.Google Scholar
  5. 5.
    Kaplan, A., Lee, V.F., (1965) “Serum lipid levels in infants and mothers at parturition”, Clin. Chim. Acta 12, 258–63.CrossRefGoogle Scholar
  6. 6.
    Dolphin, P.J., Breckenridge, W.C., Dolphin, M.A., Tan, M.H., (1984) “The lipoproteins of human: umbilical cord blood apolipoprotein and lipid levels”, Atherosclerosis 51, 109–122.CrossRefPubMedGoogle Scholar
  7. 7.
    McConathy, W.J., Lane, D.M., (1980) “Studies on the apolipoproteins and lipoproteins of cord serum”, Pediatr. Res., 14, 757–61.CrossRefPubMedGoogle Scholar
  8. 8.
    Averna, M.R., Barbagallo, C.M., Galione, A., Carroccio, A., Labisi, M., Marino, G., Montalto, G., Notarbartolo, A., (1989) “Serum apolipoprotein profile of hypertriglyceridemia patients with chronic renal failure on hemodialytic therapy: a comparison with type IV hyper1ipoproteinemic patients” Metabolism, 38, 601–2.CrossRefPubMedGoogle Scholar
  9. 9.
    Magliano, E., Rusca, M., Samaja, U., Sirtori, C.R., (1978) “Diagnosi di ipercolesterolemia alla nascita: dosaggio del colesterolo nel sangue di funicolo ombellicale in 1000 gravidanze normali”, Gaslini 10, 107–111.Google Scholar
  10. 10.
    Pagnan, A., Cerutii, A., Donadon, W., Ferrari, S., Tonolli, E., Bulian, I., Dal Palu’, C., (1976) “Cord blood cholesterol, triglycerides and lipoprotein electrophoresis in 124 Italian infants”, La Ricerca Clin. Lab., 6, 259–66.Google Scholar
  11. 11.
    Farinaro, E., Mancini, M., Trevisan, M.,Casullo, A., Di Mita, U., Rubino, A., Marotta, G., Mastranzo, P., (1979) “Plasma lipid and lipoprotein levels at birth in Naples, V International Symposium on Atherosclerosis, Houston, Texas, Abstract book, n. 399.Google Scholar
  12. 12.
    Parker, C.R. Jr., Carr, B.R., Simpson, E.R., McDonald, P.C., (1983) “Decline in the concentration of low density lipoprotein-cholesterol in human fetal plasma near term”, Metabolism 32, 919–23.CrossRefPubMedGoogle Scholar
  13. 13.
    Kwiterovich, P.O. Jr., Levy, R.I., Frederickson, D.S., (1973), “Neonatal diagnosis of familial type II hyperlipoproteinemia”, Lancet, 1, 118–22.CrossRefPubMedGoogle Scholar
  14. 14.
    Darmady, J.M., Fosbrooke, A.S., Lloyd, J.K., (1972) “Prospective study of serum cholesterol level s during first, year of life”, Br. Med. J. 2, 685–88.CrossRefPubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • M. R. Averna
    • 1
  • C. M. Barbagallo
    • 1
  • S. Amato
    • 1
  • G. Di Paola
    • 1
  • G. Marino
    • 1
  • M. Labisi
    • 1
  • U. Dimita
    • 1
  • A. Notarbartolo
    • 1
  1. 1.Department of Pathological MedicineInternal Medicine and Geriatrics InstitutePalermoItalia

Personalised recommendations