Do calcium antagonists inhibit atherogenesis?

  • P. Pauletto
  • G. Scannapieco

Abstract

In the last few years calcium antagonists have been reported to act as antiatherosclerotic agents independently from any modification of risk factors. Since these compounds have no adverse effect on plasma lipoproteins profile and are effective antihypertensives, they may represent first-line drugs in this field. However, contrasting results are reported in the literature on the antiatherogenic effect of calcium antagonists in experimental animals, and only preliminary data exist on the effect in humans. This paper summarizes the main in vivo and in vitro studies so far conducted in this field and focuses on the mechanisms by which calcium antagonists may exert their antiatherosclerotic action.

Keywords

Calcium Antagonist Atherosclerotic Lesion Cholesterol Diet Aortic Atherosclerosis Antiatherogenic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • P. Pauletto
    • 1
  • G. Scannapieco
    • 1
  1. 1.Clinica Medica IUniversità di PadovaItaly

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