The effect of LDL-apheresis on some hemostatic parameters in homozygous familial hypercholesterolemia
Some selected parameters of hemostasis that are currently thought to play a major role in thrombogenesis were evaluated in 5 patients homozygous for familial hypercholesterolemia (FH) before and 7 and 14 days after a single LDL-apheresis. The sensitivity of platelets to threshold concentrations of ADP was normal and it was not affected by LDL-apheresis. On the other hand, the sensitivity to arachidonic acid or collagen was abnormally high and this enhanced sensitivity was unchanged 7 and 14 days after the apheresis. Monocyte pro-coagulant activity (PCA) was normal before the apheresis and its values were little affected by the procedure. Likewise, the levels of plasminogen activator inhibitor (PAI) as well as the release by vessel walls of tissue plasminogen activator (tPA) the major phisiological activator of fibrinolysis were functionally and antigenicaliv normal before as well as 7 and 14 days after the apheresis. We conclude that the ability of LDL-apheresis to reduce the tendency to thrombosis of these patients is not associated with changes in these major parameters of hemostasis.
KeywordsArachidonic Acid Plasminogen Activator Inhibitor Familial Hypercholesterolemia Familial Hypercholesterolemia Familial Hypercholesterolemia Patient
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