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The effects of monounsaturated fatty acids on serum lipoprotien levels in healthy adult volunteers

  • R. P. Mensink
  • M. B. Katan

Abstract

The effects of monounsaturated fatty acids on serum lipids were studied in healthy women and men in two separate well-controlled dietary studies. In the first study it was shown that replacement of saturated fatty acids by either monounsaturated fatty acids or carbohydrates caused similar changes in serum total and LDL cholesterol levels. The HDL cholesterol level, however, was significantly lower on the diet high in carbohydrates. In the second study it was found that replacement of saturated fatty acids by a mixture of monounsaturated and polyunsaturated fatty acids caused similar serum lipid levels as replacement with polyunsaturated fatty acids alone.

It is concluded that replacement of saturated fats by oils rich in monounsaturated fatty acids might be an attractive option for optimizing serum lipid levels.

Keywords

Polyunsaturated Fatty Acid Saturated Fatty Acid Monounsaturated Fatty Acid Clinic Coronary Primary Prevention Trial Research Clinic Coronary Primary Prevention 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Keys A, Anderson JT, Grande F. Serum cholesterol response to changes in the diet. IV. Particular saturated fatty acids in the diet. Metabolism 1965; 14: 776–787.CrossRefGoogle Scholar
  2. 2.
    Hegsted DM, McGandy RB, Myers ML, Stare FJ. Quantitative effects of dietary fat on serum cholesterol in man. Am J Clin Nutr 1965; 17: 281–295.PubMedGoogle Scholar
  3. 3.
    Keys A, ed. Coronary Heart Disease in Seven Countries. Circulation 1970;41:suppl 1.Google Scholar
  4. 4.
    The Lipids Research Clinics Coronary Primary Prevention Trial Results. II. Therelationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 1984; 251: 365–374.Google Scholar
  5. 5.
    Schaefer EJ. Clinical, biochemical and genetic features in familial disorders of high density lipoproteins deficiency. Arteriosclerosis 1984; 4: 303–322.PubMedCrossRefGoogle Scholar
  6. 6.
    Vega GL, Groszek E, Wolf R, Grundy SM. Influence of polyunsaturated fats on composition of plasma lipoproteins. J Lipid Res 1982; 23: 811 – 822.PubMedGoogle Scholar
  7. 7.
    Mensink RP, Katan MB. Effect of monounsaturated fatty acids versus complex carbohydrates on high-density lipoproteins in healthy men and women. Lancet 1987;i:122–125.CrossRefGoogle Scholar
  8. 8.
    Mensink RP, Katan MB. Effect of a diet enriched with monounsaturated or polyunsaturated fatty acids on levels of low-density and high-density cholesterol in healthy women and men. N Engl J Med; 321: 436–441.Google Scholar
  9. 9.
    Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifugation. Clin Chem 1972; 18: 499–502.PubMedGoogle Scholar
  10. 10.
    Snedecor GW, Cochran WG. Statistical methods. 7th ed. Ames: Iowa State University Press, 1980.Google Scholar
  11. 11.
    Grundy SM. Comparison of monounsaturated fatty acids and carbohydrates for lowering plasma cholesterol. New Engl J Med 1986; 314: 745–748.PubMedCrossRefGoogle Scholar
  12. 12.
    West CE, Sullivan DR, Katan, MB, Halferkamps IL, van der Torre HW. Boys from populations with high carbohydrate intake have higher fasting triglycerides than boys from populations with high fat intake. Am J Epidemiol, in press.Google Scholar
  13. 13.
    Vessby B, Boberg J, Gustafsson IB, Karlström B, Lithell H, Östlund-Lindquist AM. Reduction of high density lipoprotein cholesterol and apolipoprotein A-I concentrations by a lipid-lowering diet. Atherosclerosis 1980; 35: 21–7.PubMedCrossRefGoogle Scholar
  14. 14.
    Mattson FH, Grundy SM. Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. J Lipid Res 1985; 26: 194–202.PubMedGoogle Scholar
  15. 15.
    Beynen AC, Katan MB. In: Vergroesen AJ, Crawford MA, eds. The role of fats in human nutrition. Impact of dietary cholesterol and fatty acids on serum lipids and lipoproteins in man. London: Academic Press Limited, 1989: 238–54Google Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • R. P. Mensink
    • 1
  • M. B. Katan
    • 1
  1. 1.Department of Human NutritionAgricultural UniversityWageningenThe Netherlands

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