Receptor-mediated catabolism of LDL in rabbits fed cholesterol-free, semipurified diets containing casein or soy protein: a time-course study
Rabbits were fed semipurified diets containing casein or soy protein for 4 weeks. Increases in low density lipoprotein (LDL) cholesterol and protein were apparent within the first two weeks that the diets were fed and the changes were considerably greater in the rabbits fed casein. Receptor-mediated LDL apolipoprotein B (apo B) fractional catabolic rate (FCR) was decreased within 5 days of feeding the casein diet, prior to any significant change in plasma cholesterol. These studies indicate that down regulation of LDL receptors in vivo precedes the elevation in plasma cholesterol level induced by a casein diet.
KeywordsCasein Diet Fractional Catabolic Rate Lipoprotein Protein
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