Abstract
Rabbits were fed semipurified diets containing casein or soy protein for 4 weeks. Increases in low density lipoprotein (LDL) cholesterol and protein were apparent within the first two weeks that the diets were fed and the changes were considerably greater in the rabbits fed casein. Receptor-mediated LDL apolipoprotein B (apo B) fractional catabolic rate (FCR) was decreased within 5 days of feeding the casein diet, prior to any significant change in plasma cholesterol. These studies indicate that down regulation of LDL receptors in vivo precedes the elevation in plasma cholesterol level induced by a casein diet.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Carroll, K.K. (1982) Hypercholesterolemia and atherosclerosis: Effects of dietary protein, Fed. Proc. 41, 2792–2796.
Chao, Y.S., Yamin, T.T. and Alberts, A.W. (1982) Effect of cholestyramine on LDL binding sites to liver membranes from rabbits with endogenous hypercholesterolemia induced by a wheat-starch casein diet, J. Biol. Chem, 257, 3623–3627.
Hrabek-Smith, J.M. and Carroll, K.K. (1987) A comparative study of serum lipoproteins in rabbits fed a natural ingredient or low-fat, cholesterol- free, semipurified diets containing casein or isolated soy protein, Biochem. Cell Biol. 65, 610–616.
Khosla, P., Samman, S. Carroll, K.K. and Huff, M.W. (1989a) Turnover of 125I-VLDL and 131I-LDL apolipoprotein B in rabbits fed diets containing casein or soy protein, Biochem. Biophys. Acta, 1002, 157–163.
Khosla, P., Samman, S. and Carroll, K.K. (1989b) Receptor-mediated catabolism of LDL in rabbits fed casein or soy protein. FASEB J. 3, A957.
Kita, T., Brown, M.S., Watanabe, Y. arid Goldstein, J.K. (1981) Deficiency of low density lipoprotein receptors on liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia, Proc. Natl. Acad. Sei. USA, 78, 2268–2272.
Lovati M.R., Manzoni C., Canvavesi A. et al. (1987) Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients, J. Clin. Invest., 80, 1498–1502.
Matthew C.M.E. (1957) The theory of tracer experiments with 1311-labelled plasma proteins, Phys, Med. Biol., 2, 36–53.
Redgrave T.G. (1984) Dietary proteins and atherosclerosis, Atherosclerosis, 52, 349–351.
Roberts, D.C.K., Stalmach M.E., Khalil M.W., Hutchinson J.C. and Carroll, K.K. (1981) Effects of dietary proteins on composition and turnover of apoproteins in plasma lipoproteins of rabbits, Can. J. Biochem, 56, 642–647.
Samman, S., Khosla, P. and Carroll, K.K. (1989) Effects of dietary casein and soy protein on metabolism of radiolabelled low density apolipoprotein B in rabits, Lipids, 24, 169–172.
Terpstra, A.H.M., Harkes, L. and Van Der Veen, F.H. (1981) The effect of different proportions of casein in semipurified diets on the concentration of serum cholesterol and the lipoprotein composition in rabbits. Lipids, 16, 114–119.
Weisgraber, K.H., Innerarity, T.L. and Mahley, R.W. (1978) Role of the lysine residues in high affinity binding to cell surface receptors on human fibroblasts, J.Biol. Chem., 253, 9053–9062.
Yamada, N., Shames, D.M., Stoudemire, J.B. and Havel, R.J. (1986) Metabolism of lipoproteins containing apolipoprotein B-100 in blood plasma of rabbits: heterogenity related to the presence of apolipoprotein E, Proc. Natl. Acad. Sci. USA, 83, 3479–3483.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Kluwer Academic Publishers
About this chapter
Cite this chapter
Samman, S., Khosla, P., Carroll, K.K. (1990). Receptor-mediated catabolism of LDL in rabbits fed cholesterol-free, semipurified diets containing casein or soy protein: a time-course study. In: Descovich, G., Gaddi, A., Magri, G., Lenzi, S. (eds) Atherosclerosis and Cardiovascular Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0731-7_25
Download citation
DOI: https://doi.org/10.1007/978-94-009-0731-7_25
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6814-7
Online ISBN: 978-94-009-0731-7
eBook Packages: Springer Book Archive