Hyperlipoproteinemia of lipoprotein Lp(a)
Lp(a) is a lipoprotein with unknown physiological role. All we know for sure is that individuals with high Lp(a) levels are at an increased atherosclerosis risk. The Lp(a) plasma concentration correlates inversly with the molecular weight of the apo-a isoform; this is valid, however, only in healthy persons belonging to one ethnic group. Diseases, e.g. liver or kidney damage, pregnancy and menopause profundly alter plasma Lp(a) levels, and it also appears that fertile women have higher levels as compared to man.
Many studies of various laboratories demonstrate that plasma Lp(a) concentrations correlate with the incidence of atherosclerosis and myocardial infarction. In the healthy white western population, a treshold level of approx. 25 mg/dl seems to exist below which no increased atherosclerosis risk may be evident. This value certainely has to be adapted for different ethnic groups, as well as for individuals suffering from diseases known to influence Lp(a). Unfortunately we know today only little about the possible therapeutic manipulation of plasma Lp(a) concentrations.
KeywordsLipid Lowering Drug Fertile Woman Therapeutic Manipulation Increase Atherosclerosis Risk Skew Frequency Distribution
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