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The vegetative nervous system and atrial natriuretic factor

  • F. Fontana
  • P. Bernardi

Abstract

The vegetative nervous system (VNS) and atrial natriuretic factor (ANF) are linked in various ways: 1) the VNS affects ANF release; 2) ANF changes some VNS activities and 3) the VNS influences the effects of ANF. These functional relationships have been confirmed by literature reports. Our studies on the effects of Dopamine infusion on ANF and noradrenaline (NA) plasma levels in healthy subjects and in congestive heart failure patients suggested that NA may be involved in ANF release. In diseases characterized by an increase in sympathetic tone we found that hypersympathicotonia does not appear to modify plasma ANF levels if central venous pressure (CVP) is normal as in hypovolemic shock due to melena. On the other hand, in patients with acute myocardial infarction (AMI) during bradycardia and hypotension syndrome characterized by an increase in parasympathetic tone we observed normal ANF and CVP values; this suggests that hypervagotonia curbs peptide secretion because ANF release is usually high during AMI.

Keywords

Acute Myocardial Infarction Central Venous Pressure Atrial Natriuretic Peptide Atrial Natriuretic Factor Hypovolemic Shock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • F. Fontana
    • 1
  • P. Bernardi
    • 1
  1. 1.Institute of Medical PathologyBologna University, Policlinico S. OrsolaBolognaItaly

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