Abstract
Several clinical studies using lipid-lowering diets or agents have shown that lowering total cholesterol and low density lipoprotein (LDL) -cholesterol can help prevent coronary heart disease (CHD) death and non-fatal myocardial infarction [1,2]. In addition, two recent studies have shown that elevated levels of high density lipoprotein (HDL) -cholesterol also prevent CHD events [3,4].
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References
Lipid Research Clinics Program: The Lipid Research Clinics1 Coronary Primary Prevention Trial (CPPT) Results. I and II. JAMA 1984; 251: 351–374.
Canner PL, Berge KG, Wenger NK, et al: Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol 1986; 8: 1245–1255.
Manninen V, Elo MO, Frick MH, et al: Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. JAMA 1988; 260: 641–651.
Blankenhorn DH, Nessim SA, Johnson RL, et al: Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass graphs. JAMA 1987; 257: 3233–3240.
Hjermann I, Holme I, Leren P: Oslo Study Diet and Antismoking Trial. Results after 102 months. Am J of Med 1986; 80 (2A): 7–11.
Carlson LA, Rosenhamer G: Reduction of mortality in the Stockholm Ischemic Heart Disease Secondary Prevention Study by combined treatment with Clofibrate and nicotinic acid. Acta Med Scand 1988; 223: 405–418.
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© 1990 Kluwer Academic Publishers
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Gotto, A.M. (1990). Cholesterol-CHD connection: evidence for the benefit of lipoprotein modification. In: Descovich, G., Gaddi, A., Magri, G., Lenzi, S. (eds) Atherosclerosis and Cardiovascular Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0731-7_1
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DOI: https://doi.org/10.1007/978-94-009-0731-7_1
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6814-7
Online ISBN: 978-94-009-0731-7
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