Skip to main content

Amyloid heart disease

  • Chapter
  • 38 Accesses

Part of the book series: Current Status of Clinical Cardiology ((CSOCC,volume 1))

Abstract

Virchow gave amyloid its name because the material gives a colour reaction to iodine which is similar though not identical to that given by starch. Amyloidosis is a disorder of protein metabolism and amyloid is an abnormal eosinophilic fibrillar protein which is laid down inter-cellularly. The characteristic fibrillar deposits can be formed from a number of different precursor proteins which in all cases are bound to a normal non-fibrillar glycoprotein, amyloid P component. Different forms of amyloid fibrils are identified by distinctive light and electron microscopic appearances1,2. Amyloid can be deposited in almost any organ of the body and occurs in many characteristically distinct forms in different clinical conditions and by several different pathogenetic mechanisms.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Glenner, G.G. (1980). Amyloid deposits and amyloidosis. N. Engl. J. Med., 302, 1283–1333

    Article  PubMed  CAS  Google Scholar 

  2. Kyule, R.A. and Baynd, E.D. (1975). Amyloidosis: review of 236 cases. Medicine, 54, 271

    Article  Google Scholar 

  3. Isobe, T. and Osserman, E.F. (1974). Patterns of amyloidosis and their association with plasma cell dyscrasia monoclonal immunoglobulins and Bence-Jones proteins. N. Engl. J. Med., 290, 473

    Article  PubMed  CAS  Google Scholar 

  4. Pepys, M.B. (1988). Amyloidosis: some recent developments. Q. J. Med., 67, 283

    PubMed  CAS  Google Scholar 

  5. Hodkinson, M. and Pomerance, A. (1977). The clinical significance of senile cardiac amyloidosis: A prospective clinico pathological study. Q. J. Med., 46, 677

    Google Scholar 

  6. Pitkanen, P., Westermark, P. and Cornwell, G.G. (1984). Senile systemic amyloidosis. Am. J. Pathol., 117, 391

    PubMed  CAS  Google Scholar 

  7. Hawkins, P.N., Myers, M.J., Lavender, J.P. and Pepys, M.B. (1988). Diagnostic radionuclide imaging of amyloid: biological targeting by circulating human serum amyloid P component. Lancet, 1, 1413

    Article  PubMed  CAS  Google Scholar 

  8. Buja, L.M., Khoi, N.B. and Roberts, W.C. (1970). Clinically significant cardiac amyloidosis. Am. J. Cardiol., 26, 394

    Article  PubMed  CAS  Google Scholar 

  9. James, T.N. (1965). Pathology of the cardiac conduction system in amyloidosis. Ann. Intern. Med., 65, 28

    Google Scholar 

  10. Ridolfi, R.L., Bulkley, S.H. and Hutchins, G.M. (1977). The conduction system in cardiac amyloidosis, clinical and pathological features of 23 patients. Am. J. Med., 62, 677

    Article  PubMed  CAS  Google Scholar 

  11. Cassidy, J.T. (1961). Cardiac amyloidosis: two cases with digitalis sensitivity. Ann. Intern. Med., 55, 989

    PubMed  CAS  Google Scholar 

  12. Goodwin, J.F. (1964). Cardiac function in primary myocardial disease. Br. Med. J., 1, 1526

    Google Scholar 

  13. Chew, C., Ziady, G.M., Raphael, M.J. and Oakley, C.M. (1975). The functional defect in amyloid heart disease. Am. J. Cardiol., 36, 438–44

    Article  PubMed  CAS  Google Scholar 

  14. Oakley, C.M. (1983). Amyloid heart disease. In Symons, C., Evans, T. and Mitchell, A.G. (eds.). Specific Heart Muscle Disease, (Wright PSG) 13–23

    Google Scholar 

  15. Wessler, S. and Freedberg, A.S. (1948). Cardiac amyloidosis. Electrocardiographic and pathologic observations. Arch. Intern. Med., 32, 63

    Google Scholar 

  16. Child, J.S., Levisman, J.A., Abbas, A.S. and Macalpin, RN. (1976). Echocardiographic manifestations of infiltrative cardiomyopathy. A report of seven cases due to amyloid. Chest, 70, 726–31

    Article  PubMed  CAS  Google Scholar 

  17. Borer, J.S., Henry, W.L. and Epstein, S.E. (1977). Echocardiographic observations in patients with systemic infiltrative disease involving the heart. Am. J. Cardiol., 39, 184–8

    Article  PubMed  CAS  Google Scholar 

  18. Hatle, L.K, Appleton, C.P. and Popp, R.L. (1989). Differentiation of constrictive pericarditis and restrictive cardiomyopathy by Doppler echocardiography. Circulation, 79, 357

    Article  PubMed  CAS  Google Scholar 

  19. Ehrenfeld, E.N., Eliakim, M. and Rachmilewitz, M. (1961). Recurrent polyserositis. Am. J. Med., 31, 107

    Article  Google Scholar 

  20. Brandt, K., Cathcart, E.S. and Cohen, A.S. (1969). A clinical analysis of the course and diagnosis of 42 patients with amyloidosis. Am. J. Med., 44, 955

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Kluwer Academic Publishers

About this chapter

Cite this chapter

Oakley, C.M. (1990). Amyloid heart disease. In: Julian, D.G. (eds) Current Status of Clinical Cardiology 1990. Current Status of Clinical Cardiology, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0729-4_5

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0729-4_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6813-0

  • Online ISBN: 978-94-009-0729-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics